{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:51:34Z","timestamp":1775631094127,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.ophtha.2011.05.024","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T15:18:46Z","timestamp":1313680726000},"page":"2480-2486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Effect of Cancer Therapies on Pediatric Anophthalmic Sockets"],"prefix":"10.1016","volume":"118","author":[{"given":"Yevgeniy","family":"Shildkrot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kirzhner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barrett G.","family":"Haik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Qaddoumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Rodriguez-Galindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2011.05.024_bib1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bjo.78.9.702","article-title":"Problems with the hydroxyapatite orbital implant: experience with 250 consecutive cases","volume":"78","author":"Shields","year":"1994","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0161-6420(00)00016-6","article-title":"Exposure of primary orbital implants in postenucleation retinoblastoma patients","volume":"107","author":"Lee","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00002341-200111000-00009","article-title":"Exposure rates of wrapped and unwrapped orbital implants following enucleation","volume":"17","author":"Li","year":"2001","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2011.05.024_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ophtha.2007.06.014","article-title":"Exposure rate of hydroxyapatite orbital implants: a 15-year experience of 802 cases","volume":"115","author":"Yoon","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00417-009-1262-8","article-title":"Changing causes of enucleation over the past 60 years","volume":"248","author":"Setlur","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archopht.118.4.503","article-title":"Evaluation of efficacy and complications: primary pediatric orbital implants after enucleation","volume":"118","author":"Christmas","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/bjo.2008.142679","article-title":"The success of primary chemotherapy for group D heritable retinoblastoma","volume":"93","author":"Cohen","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib8","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.ophtha.2006.04.032","article-title":"Iodine 125 plaque radiotherapy as salvage treatment for retinoblastoma recurrence after chemoreduction in 84 tumors","volume":"113","author":"Shields","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/pbc.20094","article-title":"Episcleral plaque brachytherapy for retinoblastoma","volume":"43","author":"Merchant","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ophtha.2011.05.024_bib10","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.ophtha.2007.12.014","article-title":"A phase I\/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results","volume":"115","author":"Abramson","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ohc.2004.11.003","article-title":"Intraocular retinoblastoma: the case for a new group classification","volume":"18","author":"Linn Murphree","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"key":"10.1016\/j.ophtha.2011.05.024_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/112067219800800210","article-title":"Ocular and orbital complications following the treatment of retinoblastoma","volume":"8","author":"Anteby","year":"1998","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.IOP.0000152495.25263.61","article-title":"Exposure of orbital implants wrapped with polyester-urethane after enucleation for advanced retinoblastoma","volume":"21","author":"Heimann","year":"2005","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2011.05.024_bib14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0161-6420(98)97040-3","article-title":"Porous polyethylene orbital implant in patients with retinoblastoma","volume":"105","author":"Karcioglu","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib15","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1001\/archopht.1994.01090140084028","article-title":"Use of the hydroxyapatite ocular implant in the pediatric population","volume":"112","author":"De Potter","year":"1994","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib16","first-page":"249","article-title":"Complications of hydroxyapatite orbital implants in children: a series of 105 cases [in French]","volume":"23","author":"Lumbroso","year":"2000","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib17","first-page":"1067","article-title":"Porous polyethylene (Medpor) orbital implant: prospective study of 75 primary implantations [in French]","volume":"24","author":"Van Acker","year":"2001","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1091-8531(03)00183-6","article-title":"Hydroxyapatite orbital implant exposure in children","volume":"7","author":"Nolan","year":"2003","journal-title":"J AAPOS"},{"key":"10.1016\/j.ophtha.2011.05.024_bib19","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3928\/1542-8877-20041101-03","article-title":"Management of porous polyethylene implant exposure in patients with retinoblastoma following enucleation","volume":"35","author":"Kim","year":"2004","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"10.1016\/j.ophtha.2011.05.024_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.iop.0000170406.09927.c4","article-title":"Free orbital fat graft to prevent porous polyethylene orbital implant exposure in patients with retinoblastoma","volume":"21","author":"Kim","year":"2005","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2011.05.024_bib21","first-page":"312","article-title":"Evaluation of results of enucleations with orbital implant in children and adolescents [in Polish]","volume":"108","author":"Hautz","year":"2006","journal-title":"Klin Oczna"},{"key":"10.1016\/j.ophtha.2011.05.024_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ophtha.2006.08.030","article-title":"Experience with the polymer-coated hydroxyapatite implant after enucleation in 126 patients","volume":"114","author":"Shields","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ajo.2007.03.042","article-title":"Porous orbital implants, wraps, and PEG placement in the pediatric population after enucleation","volume":"144","author":"Wang","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ajo.2004.04.062","article-title":"Porous polyethylene orbital implant in the pediatric population","volume":"138","author":"Iordanidou","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib25","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S0161-6420(94)31112-2","article-title":"Management of exposed hydroxyapatite orbital implants","volume":"101","author":"Kim","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib26","doi-asserted-by":"crossref","DOI":"10.5301\/EJO.2011.6298","article-title":"Contrast-enhanced magnetic resonance imaging of fibrovascular tissue ingrowth within synthetic hydroxyapatite orbital implants in children","author":"Galluzzi","year":"2011","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib27","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/S0161-6420(00)00178-0","article-title":"Periorbital and orbital cellulitis before and after the advent of Haemophilus influenzae type B vaccination","volume":"107","author":"Ambati","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib28","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/112067211002000607","article-title":"Periorbital and orbital cellulitis: a 10-year review of hospitalized children","volume":"20","author":"Georgakopoulos","year":"2010","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib29","doi-asserted-by":"crossref","first-page":"e1408","DOI":"10.1542\/peds.2006-2881","article-title":"Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: the effect of age [report online]","volume":"119","author":"Revai","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.ophtha.2011.05.024_bib30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/194589240101500606","article-title":"Allergic rhinitis as a risk factor for orbital complication of acute rhinosinusitis in children","volume":"15","author":"Holzmann","year":"2001","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0196-0709(91)90121-U","article-title":"Distribution and incidence of North American pollen aeroallergens","volume":"12","author":"Lewis","year":"1991","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib32","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1086\/528685","article-title":"Viral upper respiratory tract infection and otitis media complication in young children","volume":"46","author":"Chonmaitree","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ophtha.2011.05.024_bib33","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1200\/JCO.1997.15.3.1183","article-title":"Orbital development in long-term survivors of retinoblastoma","volume":"15","author":"Kaste","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00002341-199901000-00008","article-title":"Orbital development after enucleation in early childhood","volume":"15","author":"Fountain","year":"1999","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2011.05.024_bib35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archopht.119.3.379","article-title":"Pediatric enucleation: analysis of volume replacement","volume":"119","author":"Kaltreider","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.05.024_bib36","first-page":"568","article-title":"A comparison of implant extrusion rates and postoperative pain after evisceration with immediate or delayed implants and after enucleation with implants","volume":"103","author":"Liu","year":"2005","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ophtha.2011.05.024_bib37","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/S0161-6420(03)00857-1","article-title":"Orbital implants in enucleation surgery: a report by the American Academy of Ophthalmology","volume":"110","author":"Custer","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.05.024_bib38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.IOP.0000083643.36461.84","article-title":"The porous polyethylene (Medpor) spherical orbital implant: a retrospective study of 136 cases","volume":"19","author":"Blaydon","year":"2003","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2011.05.024_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/IOP.0b013e3181b80c30","article-title":"The bioceramic implant: evaluation of implant exposures in 419 implants","volume":"26","author":"Jordan","year":"2010","journal-title":"Ophthal Plast Reconstr Surg"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642011004696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642011004696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:02:48Z","timestamp":1758981768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642011004696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0161642011004696"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2011.05.024","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Cancer Therapies on Pediatric Anophthalmic Sockets","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2011.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}