{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:29:26Z","timestamp":1792711766476,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.ophtha.2011.10.010","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T21:06:59Z","timestamp":1327698419000},"page":"731-737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":237,"title":["Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography"],"prefix":"10.1016","volume":"119","author":[{"given":"Christopher K.S.","family":"Leung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.C.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2011.10.010_bib1","first-page":"1","article-title":"Aging of the human retina: differential loss of neurons and retinal pigment epithelial cells","volume":"33","author":"Gao","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/1097-0185(20001001)260:2<124::AID-AR20>3.0.CO;2-D","article-title":"Neuronal density in the human retinal ganglion cell layer from 16-77 years","volume":"260","author":"Harman","year":"2000","journal-title":"Anat Rec"},{"key":"10.1016\/j.ophtha.2011.10.010_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0197-4580(96)00038-3","article-title":"Effects of aging on the densities, numbers, and sizes of retinal ganglion cells in rhesus monkey","volume":"17","author":"Kim","year":"1996","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.ophtha.2011.10.010_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/(SICI)1097-0185(19990901)256:1<78::AID-AR10>3.0.CO;2-K","article-title":"Number of neurons in the retinal ganglion cell layer of the quokka wallaby do not change throughout life","volume":"256","author":"Harman","year":"1999","journal-title":"Anat Rec"},{"key":"10.1016\/j.ophtha.2011.10.010_bib5","first-page":"2012","article-title":"Human optic nerve fiber count and optic disc size","volume":"33","author":"Jonas","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0161-6420(89)32928-9","article-title":"The effect of age on normal human optic nerve fiber number and diameter","volume":"96","author":"Repka","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib7","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/archophthalmol.2010.244","article-title":"Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes","volume":"128","author":"Hirasawa","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.10.010_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000070634","article-title":"Evaluation of the effect of aging on retinal nerve fiber layer thickness measured by optical coherence tomography","volume":"217","author":"Kanamori","year":"2003","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.ophtha.2011.10.010_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/bjo.84.5.473","article-title":"Relation of optic disc topography and age to thickness of retinal nerve fibre layer as measured using scanning laser polarimetry, in normal subjects","volume":"84","author":"Toprak","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.10.010_bib10","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2006.08.046","article-title":"Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT","volume":"114","author":"Budenz","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ophtha.2007.01.023","article-title":"Normal age-related decay of retinal nerve fiber layer thickness","volume":"114","author":"Parikh","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ophtha.2009.01.004","article-title":"Effects of age on optical coherence tomography measurements of healthy retinal nerve fiber layer, macula, and optic nerve head","volume":"116","author":"Sung","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib13","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1136\/bjo.82.11.1242","article-title":"Relation between size of optic disc and thickness of retinal nerve fibre layer in normal subjects","volume":"82","author":"Funaki","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.10.010_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0301-4738.21608","article-title":"Retinal nerve fibre layer thickness measurements in normal Indian population by optical coherence tomography","volume":"54","author":"Ramakrishnan","year":"2006","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.10.010_bib15","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1167\/iovs.03-0514","article-title":"Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT","volume":"45","author":"Paunescu","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ophtha.2007.05.035","article-title":"Reproducibility of peripapillary retinal nerve fiber thickness measurements with Stratus OCT in glaucomatous eyes","volume":"115","author":"Budenz","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib17","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1167\/iovs.04-1174","article-title":"Reproducibility of retinal nerve fiber thickness measurements using the Stratus OCT in normal and glaucomatous eyes","volume":"46","author":"Budenz","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib18","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1167\/iovs.07-1187","article-title":"Longitudinal variability of optic disc and retinal nerve fiber layer measurements","volume":"49","author":"Leung","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib19","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ophtha.2009.04.013","article-title":"Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study","volume":"116","author":"Leung","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib20","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.ophtha.2011.01.026","article-title":"Evaluation of retinal nerve fiber layer progression in glaucoma: a comparison between spectral-domain and time-domain optical coherence tomography","volume":"118","author":"Leung","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1364\/OL.29.000480","article-title":"In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography","volume":"29","author":"Nassif","year":"2004","journal-title":"Opt Lett"},{"key":"10.1016\/j.ophtha.2011.10.010_bib22","first-page":"4.18","article-title":"Cirrus HD-OCT user manual","year":"2008"},{"key":"10.1016\/j.ophtha.2011.10.010_bib23","first-page":"22","article-title":"Analysis of Longitudinal Data","author":"Diggle","year":"2002"},{"key":"10.1016\/j.ophtha.2011.10.010_bib24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2307\/2533554","article-title":"Sample size calculations for studies with correlated observations","volume":"53","author":"Liu","year":"1997","journal-title":"Biometrics"},{"key":"10.1016\/j.ophtha.2011.10.010_bib25","author":"Donohue"},{"key":"10.1016\/j.ophtha.2011.10.010_bib26","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1167\/iovs.06-0545","article-title":"Retinal nerve fiber layer measurements in myopia: an optical coherence tomography study","volume":"47","author":"Leung","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib27","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1167\/iovs.09-4737","article-title":"Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography","volume":"51","author":"Kang","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/IJG.0b013e318193c2be","article-title":"Myopia affects retinal nerve fiber layer measurements as determined by optical coherence tomography","volume":"18","author":"Rauscher","year":"2009","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ophtha.2011.10.010_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/IJG.0b013e31817eee20","article-title":"Signal strength is an important determinant of accuracy of nerve fiber layer thickness measurement by optical coherence tomography","volume":"18","author":"Wu","year":"2009","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ophtha.2011.10.010_bib30","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/bjo.2008.152223","article-title":"Scan quality effect on glaucoma discrimination by glaucoma imaging devices","volume":"93","author":"Sung","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2011.10.010_bib31","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.ophtha.2007.11.027","article-title":"Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography","volume":"115","author":"Cheung","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2011.10.010_bib32","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1167\/iovs.08-2712","article-title":"Detection of progressive retinal nerve fiber layer loss in glaucoma using scanning laser polarimetry with variable corneal compensation","volume":"50","author":"Medeiros","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1167\/iovs.09-3468","article-title":"Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis","volume":"51","author":"Leung","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib34","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1167\/iovs.08-1753","article-title":"Age-related losses of retinal ganglion cells and axons","volume":"49","author":"Harwerth","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1167\/iovs.05-0520","article-title":"Age-dependent susceptibility of the retinal ganglion cell layer to cell death","volume":"47","author":"McKernan","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib36","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/cne.902190309","article-title":"Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat","volume":"219","author":"Perry","year":"1983","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ophtha.2011.10.010_bib37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/IJG.0b013e3181629a02","article-title":"Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography","volume":"17","author":"Hood","year":"2008","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ophtha.2011.10.010_bib38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/IJG.0b013e3181af31ec","article-title":"The location of the inferior and superior temporal blood vessels and interindividual variability of the retinal nerve fiber layer thickness","volume":"19","author":"Hood","year":"2010","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ophtha.2011.10.010_bib39","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1167\/iovs.03-0079","article-title":"Retinal vessel diameters and their associations with age and blood pressure","volume":"44","author":"Wong","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2011.10.010_bib40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.survophthal.2008.10.003","article-title":"Retinal vascular caliber: systemic, environmental, and genetic associations","volume":"54","author":"Sun","year":"2009","journal-title":"Surv Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642011009572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642011009572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:02:44Z","timestamp":1758981764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642011009572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0161642011009572"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2011.10.010","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2011.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}