{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:26:33Z","timestamp":1791199593180,"version":"4.2.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.ophtha.2012.01.024","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T08:02:10Z","timestamp":1331625730000},"page":"1465-1469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Ocular Whipple's Disease: Therapeutic Strategy and Long-Term Follow-Up"],"prefix":"10.1016","volume":"119","author":[{"given":"Val\u00e9rie","family":"Touitou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Fenollar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cassoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Merle-Beral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc","family":"LeHoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahir","family":"Amoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Drancourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Bodaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2012.01.024_bib1","first-page":"382","article-title":"A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues","volume":"18","author":"Whipple","year":"1907","journal-title":"Bull Johns Hopkins Hosp"},{"key":"10.1016\/j.ophtha.2012.01.024_bib2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0016-5085(19)36367-X","article-title":"A case of Whipple's disease (intestinal lipodystrophy)","volume":"22","author":"Paulley","year":"1952","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ophtha.2012.01.024_bib3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0140-6736(91)90545-Z","article-title":"Phylogeny of the Whipple's-disease-associated bacterium","volume":"338","author":"Wilson","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ophtha.2012.01.024_bib4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJM200003023420903","article-title":"Cultivation of the bacillus of Whipple's disease","volume":"342","author":"Raoult","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ophtha.2012.01.024_bib5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1159\/000233288","article-title":"New insights into Whipple's disease\u2014a rare intestinal inflammatory disorder","volume":"27","author":"Marth","year":"2009","journal-title":"Dig Dis"},{"key":"10.1016\/j.ophtha.2012.01.024_bib6","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S0161-6420(98)91036-3","article-title":"Whipple's syndrome (uveitis, B27-negative spondylarthropathy, meningitis, and lymphadenopathy) associated with Arthrobacter sp. infection","volume":"105","author":"Bodaghi","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2012.01.024_bib7","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/archopht.1984.01040030302024","article-title":"Manifestations of Whipple's disease in the posterior segment of the eye","volume":"102","author":"Avila","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib8","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/S0161-6420(01)00818-1","article-title":"Ocular Whipple's disease: earlier definitive diagnosis","volume":"108","author":"Chan","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2012.01.024_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00041327-200203000-00006","article-title":"Whipple disease with supranuclear ophthalmoplegia diagnosed by polymerase chain reaction of cerebrospinal fluid","volume":"22","author":"Lee","year":"2002","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00006982-198400420-00006","article-title":"Ocular involvement in Whipple's disease","volume":"4","author":"Selsky","year":"1984","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2012.01.024_bib11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00005792-200211000-00005","article-title":"Neurologic presentation of Whipple disease: report of 12 cases and review of the literature","volume":"81","author":"Gerard","year":"2002","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ophtha.2012.01.024_bib12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7326\/0003-4819-126-7-199704010-00004","article-title":"Diagnosis and monitoring of Whipple disease by polymerase chain reaction","volume":"126","author":"Ramzan","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ophtha.2012.01.024_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0140-6736(96)90505-X","article-title":"Polymerase chain reaction of cerebrospinal fluid to diagnose Whipple's disease [letter]","volume":"347","author":"Cohen","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ophtha.2012.01.024_bib14","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1053\/gast.1996.v110.pm8964398","article-title":"Diagnostic application of a polymerase chain reaction assay for the Whipple's disease bacterium to intestinal biopsies","volume":"110","author":"von Herbay","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ophtha.2012.01.024_bib15","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMc061049","article-title":"Culture of T. whipplei from the stool of a patient with Whipple's disease [letter]","volume":"355","author":"Raoult","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ophtha.2012.01.024_bib16","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.7326\/0003-4819-139-12-200312160-00025","article-title":"Culture of Tropheryma whippelii from the vitreous fluid of a patient presenting with unilateral uveitis [letter]","volume":"139","author":"Drancourt","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ophtha.2012.01.024_bib17","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1086\/528693","article-title":"Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates","volume":"197","author":"Fenollar","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ophtha.2012.01.024_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00005792-199705000-00003","article-title":"Whipple disease: clinical review of 52 cases","volume":"76","author":"Durand","year":"1997","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ophtha.2012.01.024_bib19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0248-8663(96)80772-7","article-title":"Uveitis: late complication of undiagnosed Whipple disease [in French]","volume":"16","author":"Wechsler","year":"1995","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.ophtha.2012.01.024_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/MD.0b013e3181f204a8","article-title":"Systemic Tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center","volume":"89","author":"Lagier","year":"2010","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ophtha.2012.01.024_bib21","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0002-9394(98)00084-1","article-title":"Whipple disease presenting as posterior uveitis without prominent gastrointestinal symptoms","volume":"126","author":"Nishimura","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib22","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0755-4982(05)84217-4","article-title":"Whipple disease, initially diagnosed as sarcoidosis [in French]","volume":"34","author":"Saba","year":"2005","journal-title":"Presse Med"},{"key":"10.1016\/j.ophtha.2012.01.024_bib23","first-page":"677","article-title":"Lipodystrophy intestinalis (Whipple's disease)","volume":"24","author":"Black-Schaffer","year":"1948","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1099\/00222615-46-4-340","article-title":"Strategy for detection and identification of bacteria based on 16S rRNA genes in suspected cases of Whipple's disease","volume":"46","author":"Dauga","year":"1997","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib25","first-page":"48","article-title":"False positive PCR detection of Tropheryma whipplei in the saliva of healthy people","volume":"7","author":"Rolain","year":"2007","journal-title":"BMC Microbiol [serial online]"},{"key":"10.1016\/j.ophtha.2012.01.024_bib26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/AAC.48.3.747-752.2004","article-title":"Antibiotic susceptibility of Tropheryma whipplei in MRC5 cells","volume":"48","author":"Boulos","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ophtha.2012.01.024_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.11150\/kansenshogakuzasshi1970.57.148","article-title":"A study on the penetration of sulfamethoxazole-trimethoprim into the cerebrospinal fluid [in Japanese]","volume":"57","author":"Chen","year":"1983","journal-title":"Kansenshogaku Zasshi"},{"key":"10.1016\/j.ophtha.2012.01.024_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0025-6196(12)64892-7","article-title":"Whipple's disease","volume":"63","author":"Dobbins","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ophtha.2012.01.024_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0025-6196(12)64884-8","article-title":"Whipple's disease: clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients","volume":"63","author":"Fleming","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ophtha.2012.01.024_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijantimicag.2009.02.014","article-title":"Resistance to trimethoprim\/sulfamethoxazole and Tropheryma whipplei","volume":"34","author":"Fenollar","year":"2009","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ophtha.2012.01.024_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1086\/588706","article-title":"Acquired resistance to trimethoprim-sulfamethoxazole during Whipple disease and expression of the causative target gene","volume":"198","author":"Bakkali","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ophtha.2012.01.024_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ana.410410425","article-title":"Treatment guidelines in central nervous system Whipple's disease [letter]","volume":"41","author":"Schnider","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1473-3099(08)70042-2","article-title":"Whipple's disease: new aspects of pathogenesis and treatment","volume":"8","author":"Schneider","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ophtha.2012.01.024_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ana.410400404","article-title":"Diagnostic guidelines in central nervous system Whipple's disease","volume":"40","author":"Louis","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ophtha.2012.01.024_bib35","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/0016-5085(85)90012-5","article-title":"Antibiotic treatment and relapse in Whipple's disease: long-term follow-up of 88 patients","volume":"88","author":"Keinath","year":"1985","journal-title":"Gastroenterology"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642012000498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642012000498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:01:49Z","timestamp":1758981709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642012000498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0161642012000498"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2012.01.024","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ocular Whipple's Disease: Therapeutic Strategy and Long-Term Follow-Up","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2012.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}