{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:41:33Z","timestamp":1774611693382,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.ophtha.2013.08.007","type":"journal-article","created":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T08:17:27Z","timestamp":1379924247000},"page":"72-78","source":"Crossref","is-referenced-by-count":41,"title":["Effectiveness of Nonpharmacologic Treatments for Acute Seasonal Allergic Conjunctivitis"],"prefix":"10.1016","volume":"121","clinical-trial-number":[{"clinical-trial-number":"nct01569191","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Paramdeep S.","family":"Bilkhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wolffsohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehzad A.","family":"Naroo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2013.08.007_bib1","first-page":"74","article-title":"The mechanisms, diagnosis and treatment of allergy","volume":"9","author":"Abelson","year":"2002","journal-title":"Rev Ophthalmol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.iac.2007.12.011","article-title":"Ocular allergy overview","volume":"28","author":"Bielory","year":"2008","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.ophtha.2013.08.007_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.clae.2010.12.008","article-title":"Prevalence and impact of ocular allergy in the population attending UK optometric practice","volume":"34","author":"Wolffsohn","year":"2011","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2013.08.007_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mcna.2005.08.013","article-title":"Allergic diseases of the eye","volume":"90","author":"Bielory","year":"2006","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.ophtha.2013.08.007_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1076\/opep.11.1.17.26437","article-title":"Economic and quality-of-life impact of seasonal allergic conjunctivitis in Oxfordshire","volume":"11","author":"Pitt","year":"2004","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/09286580590967781","article-title":"The economic and quality of life impact of seasonal allergic conjunctivitis in a Spanish setting","volume":"12","author":"Smith","year":"2005","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/CRIAI:20:2:201","article-title":"Ocular allergy treatments","volume":"20","author":"Bielory","year":"2001","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11882-001-0051-1","article-title":"Overview of ocular allergy treatment","volume":"1","author":"Friedlaender","year":"2001","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.ophtha.2013.08.007_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.iac.2007.12.001","article-title":"Ocular allergy treatment","volume":"28","author":"Bielory","year":"2008","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.ophtha.2013.08.007_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2165\/00003495-199550020-00002","article-title":"Therapeutic options in ocular allergic disease","volume":"50","author":"Hingorani","year":"1995","journal-title":"Drugs"},{"key":"10.1016\/j.ophtha.2013.08.007_bib11","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2165\/00003495-200262110-00004","article-title":"Ocular allergy guidelines: a practical treatment algorithm","volume":"62","author":"Bielory","year":"2002","journal-title":"Drugs"},{"key":"10.1016\/j.ophtha.2013.08.007_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.clae.2009.08.002","article-title":"The management of allergic eye diseases in primary care","volume":"32","author":"Chigbu","year":"2009","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2013.08.007_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archopht.1990.01070030090035","article-title":"Conjunctival allergen challenge: a clinical approach to studying allergic conjunctivitis","volume":"108","author":"Abelson","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib14","first-page":"689","article-title":"Conjunctival allergen challenge: practical recommendations for the diagnosis of allergic conjunctivitis. Report (proceedings) of the meeting of the Group Ophthalmo Allergo (Journ\u00e9es parisiennes d\u2019allergie, January 10, 2004)","volume":"44","author":"Fauqert","year":"2004","journal-title":"Rev Fr Allergol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/01.all.0000182539.45348.87","article-title":"In-vivo diagnostic measurements of ocular inflammation","volume":"5","author":"Leonardi","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1542-0124(12)70196-9","article-title":"Methodologies for the study of ocular surface disease","volume":"3","author":"Ousler","year":"2005","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ophtha.2013.08.007_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.clae.2010.01.004","article-title":"Objective clinical performance of \u2018comfort-enhanced\u2019 daily disposable soft contact lenses","volume":"33","author":"Wolffsohn","year":"2010","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2013.08.007_bib18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0091-6749(99)70380-5","article-title":"Validation of the standardised version of the Rhinoconjunctivitis Quality of Life Questionnaire","volume":"104","author":"Juniper","year":"1999","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1046\/j.1475-1313.2002.00020.x","article-title":"The application of analysis of variance (ANOVA) to different experimental designs in optometry","volume":"22","author":"Armstrong","year":"2002","journal-title":"Ophthalmic Physiol Opt"},{"key":"10.1016\/j.ophtha.2013.08.007_bib20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.clae.2011.03.004","article-title":"Role of contact lenses in relieving ocular allergy","volume":"34","author":"Wolffsohn","year":"2011","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2013.08.007_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2222.1979.tb01553.x","article-title":"Group comparative trial of 2% sodium cromoglycate (Opticrom) with placebo in the treatment of seasonal allergic conjunctivitis","volume":"9","author":"Lindsay-Miller","year":"1979","journal-title":"Clin Allergy"},{"key":"10.1016\/j.ophtha.2013.08.007_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1398-9995.1993.tb01108.x","article-title":"Topical levocabastine is more effective than sodium cromoglycate for the prophylaxis and treatment of seasonal allergic conjunctivitis","volume":"48","author":"Davies","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.ophtha.2013.08.007_bib23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11882-003-0100-z","article-title":"Conjunctival allergen challenge: models in the investigation of ocular allergy","volume":"3","author":"Abelson","year":"2003","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.ophtha.2013.08.007_bib24","first-page":"212","article-title":"Management of ocular allergy","volume":"75","author":"Friedlaender","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.ophtha.2013.08.007_bib25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1444-0938.2000.tb05014.x","article-title":"Ocular allergy: causes and therapeutic options","volume":"83","author":"Schmid","year":"2009","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.ophtha.2013.08.007_bib26","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1358\/dot.1998.34.11.487480","article-title":"Ocular allergic disease","volume":"34","author":"Bhargava","year":"1998","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.ophtha.2013.08.007_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/01.iio.0000212136.77675.b1","article-title":"Elestat (epinastine HCl ophthalmic solution 0.05%) as a therapeutic for allergic conjunctivitis","volume":"46","author":"Trattler","year":"2006","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2013.08.007_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/01.iio.0000212128.45395.a5","article-title":"Epinastine in the management of ocular allergic disease","volume":"46","author":"Friedlaender","year":"2006","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2013.08.007_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0149-2918(04)90004-5","article-title":"Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis","volume":"26","author":"Abelson","year":"2004","journal-title":"Clin Ther"},{"key":"10.1016\/j.ophtha.2013.08.007_bib30","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1185\/030079904125004330","article-title":"Clinical efficacy of olopatadine vs epinastine ophthalmic solution in the conjunctival allergen challenge model","volume":"20","author":"Lanier","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.ophtha.2013.08.007_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0149-2918(04)90003-3","article-title":"Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis","volume":"26","author":"Whitcup","year":"2004","journal-title":"Clin Ther"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642013007239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642013007239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T14:38:04Z","timestamp":1531233484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642013007239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0161642013007239"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2013.08.007","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}