{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:52:48Z","timestamp":1768265568929,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.ophtha.2014.06.005","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T13:30:16Z","timestamp":1405431016000},"page":"2098-2106.e2","source":"Crossref","is-referenced-by-count":26,"title":["Microstructure of the Optic Disc Pit in Open-Angle Glaucoma"],"prefix":"10.1016","volume":"121","author":[{"given":"Yun Jeong","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Hyuk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2014.06.005_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.62.6.389","article-title":"Pit-like changes of the optic nerve head in open-angle glaucoma","volume":"62","author":"Radius","year":"1978","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0161-6420(90)32466-1","article-title":"Acquired pits of the optic nerve. Increased prevalence in patients with low-tension glaucoma","volume":"97","author":"Javitt","year":"1990","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0161-6420(95)30873-1","article-title":"Central visual field changes associated with acquired pits of the optic nerve","volume":"102","author":"Cashwell","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0002-9394(99)80185-8","article-title":"Acquired pit of the optic nerve: a risk factor for progression of glaucoma","volume":"125","author":"Ugurlu","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1034\/j.1600-0420.1998.760304.x","article-title":"Acquired pits of the optic nerve in glaucoma: prevalence and associated visual field loss","volume":"76","author":"Nduaguba","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ophtha.2014.06.005_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/IJG.0b013e318133fc34","article-title":"The prevalence of optic disc pits and their relationship to glaucoma","volume":"17","author":"Healey","year":"2008","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2014.06.005_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1755-3768.1981.tb06703.x","article-title":"Disc haemorrhage and glaucoma","volume":"59","author":"Bengtsson","year":"1981","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.ophtha.2014.06.005_bib8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0161-6420(86)33658-3","article-title":"Optic disc hemorrhage in low-tension glaucoma","volume":"93","author":"Kitazawa","year":"1986","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0161-6420(98)92704-X","article-title":"Optic disc hemorrhages in a population with and without signs of glaucoma","volume":"105","author":"Healey","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/0002-9394(84)90505-1","article-title":"Comparison of visual field defects in the low-tension glaucomas with those in the high-tension glaucomas","volume":"97","author":"Caprioli","year":"1984","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0002-9394(86)90028-0","article-title":"Comparison of visual field defects in normal-tension glaucoma and high-tension glaucoma","volume":"102","author":"Caprioli","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib12","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.ophtha.2011.02.013","article-title":"Initial parafoveal versus peripheral scotomas in glaucoma: risk factors and visual field characteristics","volume":"118","author":"Park","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib13","first-page":"778","article-title":"The optic nerve workup","volume":"83","author":"Smith","year":"1977","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib14","first-page":"103","article-title":"Optic nerve infarction","volume":"75","author":"Lichter","year":"1977","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"Suppl","key":"10.1016\/j.ophtha.2014.06.005_bib15","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/0039-6257(94)90042-6","article-title":"A\u00a0new classification of glaucoma including focal glaucoma","volume":"38","author":"Spaeth","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib16","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced depth imaging spectral-domain optical coherence tomography","volume":"146","author":"Spaide","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ajo.2011.01.024","article-title":"Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography","volume":"152","author":"Lee","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib18","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1001\/archopthalmol.2011.1309","article-title":"In\u00a0vivo evaluation of focal lamina cribrosa defects in glaucoma","volume":"130","author":"Kiumehr","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib19","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1167\/iovs.13-13014","article-title":"Factors associated with focal lamina cribrosa defects in glaucoma","volume":"54","author":"Park","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1001\/jamaophthalmol.2013.1926","article-title":"Focal lamina cribrosa defects associated with glaucomatous rim thinning and acquired pits","volume":"131","author":"You","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ophtha.2011.07.012","article-title":"Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma","volume":"119","author":"Park","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1586\/17434440.2013.827505","article-title":"Improved visualization of deep ocular structures in glaucoma using high penetration optical coherence tomography","volume":"10","author":"Mansouri","year":"2013","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.ophtha.2014.06.005_bib23","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1167\/iovs.13-11677","article-title":"Three-dimensional imaging of lamina cribrosa defects in glaucoma using swept-source optical coherence tomography","volume":"54","author":"Takayama","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib24","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.ophtha.2012.01.047","article-title":"Acquired optic nerve and peripapillary pits in pathologic myopia","volume":"119","author":"Ohno-Matsui","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib25","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1167\/iovs.13-12901","article-title":"Evaluation of\u00a0congenital optic disc pits and optic disc colobomas by swept-source optical coherence tomography","volume":"54","author":"Ohno-Matsui","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib26","series-title":"Statistical Methods for Rates and Proportions","first-page":"604","article-title":"The measurement of interrater agreement","author":"Fleiss","year":"2003"},{"key":"10.1016\/j.ophtha.2014.06.005_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ophtha.2013.08.018","article-title":"Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss","volume":"121","author":"Tatham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.005_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archopht.1981.03930010139020","article-title":"Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2014.06.005_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/glia.21242","article-title":"Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure","volume":"60","author":"Dai","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.ophtha.2014.06.005_bib31","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.brainresbull.2003.07.008","article-title":"Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma","volume":"62","author":"Arend","year":"2004","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.ophtha.2014.06.005_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/OPX.0b013e31817841cb","article-title":"Mechanical environment of the optic nerve head in glaucoma","volume":"85","author":"Downs","year":"2008","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","article-title":"The optic nerve head in glaucoma: role of astrocytes in tissue remodeling","volume":"19","author":"Hernandez","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2014.06.005_bib34","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1167\/iovs.10-5467","article-title":"The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells","volume":"52","author":"Quill","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib35","first-page":"365","article-title":"Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia","volume":"42","author":"Yang","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib36","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archopht.1985.01050080057020","article-title":"Comparison of the optic nerve head in high- and low-tension glaucoma","volume":"103","author":"Caprioli","year":"1985","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib37","first-page":"882","article-title":"Comparison of optic disc features in low-tension and typical open-angle glaucoma","volume":"18","author":"Miller","year":"1987","journal-title":"Ophthalmic Surg"},{"key":"10.1016\/j.ophtha.2014.06.005_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/tvst.1.1.3","article-title":"The nature of macular damage in glaucoma as revealed by averaging optical coherence tomography data","volume":"1","author":"Hood","year":"2012","journal-title":"Transl Vis Sci Technol [serial online]"},{"key":"10.1016\/j.ophtha.2014.06.005_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.08.003","article-title":"Glaucomatous damage of the macula","volume":"32","author":"Hood","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2014.06.005_bib40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF02186668","article-title":"Effect of retinal nerve fibre loss on the optic nerve head configuration in early glaucoma","volume":"220","author":"Airaksinen","year":"1983","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib41","first-page":"914","article-title":"Reading performance in patients with central visual field disturbance due to glaucoma","volume":"110","author":"Fujita","year":"2006","journal-title":"Nihon Ganka Gakkai Zasshi"},{"key":"10.1016\/j.ophtha.2014.06.005_bib42","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archopht.120.11.1509","article-title":"The effect of visual field defects on driving performance: a driving simulator study","volume":"120","author":"Coeckelbergh","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib43","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ajo.2006.10.054","article-title":"Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure","volume":"143","author":"Kahook","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib44","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1097\/OPX.0b013e3181d1dad5","article-title":"Peripapillary schisis with serous detachment in advanced glaucoma","volume":"87","author":"Farjad","year":"2010","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.005_bib45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ajo.2007.03.027","article-title":"Macular schisis and detachment associated with presumed acquired enlarged optic nerve head cups","volume":"144","author":"Zumbro","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/archopht.1996.01100130159008","article-title":"Imaging congenital optic disc pits and associated maculopathy using optical coherence tomography","volume":"114","author":"Krivoy","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib47","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1007\/s00417-006-0267-9","article-title":"Intracranial migration of silicone oil from an eye with optic pit","volume":"244","author":"Kuhn","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.005_bib48","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/IAE.0b013e3181d87ecb","article-title":"High-resolution optical coherence tomography findings in optic pit maculopathy","volume":"30","author":"Imamura","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.06.005_bib49","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00417-011-1698-5","article-title":"Optic disc pit: a review","volume":"249","author":"Georgalas","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014005065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014005065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T15:52:40Z","timestamp":1538409160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642014005065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0161642014005065"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2014.06.005","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}