{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:11:08Z","timestamp":1790287868214,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ophtha.2014.06.047","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T08:47:23Z","timestamp":1408524443000},"page":"2371-2379","source":"Crossref","is-referenced-by-count":66,"title":["Relationship between Ganglion Cell Layer Thickness and Estimated Retinal Ganglion Cell Counts in the Glaucomatous Macula"],"prefix":"10.1016","volume":"121","author":[{"given":"Chunwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Tatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Zangwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Z.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2014.06.047_bib1","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.ophtha.2014.06.047_bib2","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1167\/iovs.12-10515","article-title":"The shape of the ganglion cell plus inner plexiform layers of the normal human macula","volume":"53","author":"Knighton","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1167\/iovs.10-5803","article-title":"Initial arcuate defects within the central 10 degrees in glaucoma","volume":"52","author":"Hood","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cne.903000103","article-title":"Topography of ganglion cells in human retina","volume":"300","author":"Curcio","year":"1990","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib5","first-page":"75","article-title":"Frequency distribution in early glaucomatous visual field defects","volume":"14","author":"Aulhorn","year":"1977","journal-title":"Doc Ophthalmol Proc Ser"},{"key":"10.1016\/j.ophtha.2014.06.047_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1001\/archopht.1984.01040030281019","article-title":"Early foveal involvement and generalized depression of the visual field in glaucoma","volume":"102","author":"Anctil","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib7","first-page":"131","article-title":"Location of early glaucomatous visual field defects","volume":"15","author":"Nicholas","year":"1980","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0161-6420(98)92743-9","article-title":"Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study","volume":"105","author":"Zeimer","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.047_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.08.003","article-title":"Glaucomatous damage of the macula","volume":"32","author":"Hood","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2014.06.047_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajo.2004.08.069","article-title":"Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography","volume":"139","author":"Medeiros","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib11","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.ophtha.2009.05.025","article-title":"Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography","volume":"116","author":"Tan","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.047_bib12","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1167\/iovs.10-5572","article-title":"Three-dimensional imaging of macular inner structures in glaucoma by using spectral-domain optical coherence tomography","volume":"52","author":"Kotera","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/IJG.0b013e3181e079ed","article-title":"Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using spectral domain optical coherence tomography","volume":"20","author":"Nakatani","year":"2011","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2014.06.047_bib14","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.ophtha.2010.01.031","article-title":"Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis","volume":"117","author":"Rao","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.047_bib15","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1167\/iovs.09-4258","article-title":"Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma","volume":"51","author":"Seong","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/eye.2010.139","article-title":"Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma","volume":"25","author":"Garas","year":"2011","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ophtha.2014.06.047_bib17","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1136\/bjo.2010.182493","article-title":"Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia","volume":"95","author":"Kim","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib18","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1167\/iovs.11-7962","article-title":"Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma","volume":"52","author":"Mwanza","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ophtha.2011.12.014","article-title":"Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head","volume":"119","author":"Mwanza","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.047_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.preteyeres.2010.02.001","article-title":"Linking structure and function in glaucoma","volume":"29","author":"Harwerth","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2014.06.047_bib21","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/archophthalmol.2012.827","article-title":"A\u00a0combined index of structure and function for staging glaucomatous damage","volume":"130","author":"Medeiros","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib22","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1167\/iovs.12-10345","article-title":"The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change","volume":"53","author":"Medeiros","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib23","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ajo.2012.04.022","article-title":"Estimating the rate of retinal ganglion cell loss in glaucoma","volume":"154","author":"Medeiros","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib24","doi-asserted-by":"crossref","first-page":"e76590","DOI":"10.1371\/journal.pone.0076590","article-title":"The relationship between visual field index and estimated number of retinal ganglion cells in glaucoma","volume":"8","author":"Marvasti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2014.06.047_bib25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ophtha.2012.09.039","article-title":"Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma","volume":"120","author":"Medeiros","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.047_bib26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archophthalmol.2009.187","article-title":"The African descent and glaucoma evaluation study (ADAGES): design and baseline data","volume":"127","author":"Sample","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib27","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1001\/archopht.123.10.1351","article-title":"Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma","volume":"123","author":"Medeiros","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib28","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.ophtha.2007.11.008","article-title":"Comparison of retinal nerve fiber layer and optic disc imaging for diagnosing glaucoma in patients suspected of having the disease","volume":"115","author":"Medeiros","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.06.047_bib29","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1136\/bjophthalmol-2013-303660","article-title":"Relationship between ganglion cell-inner plexiform layer and optic disc\/retinal nerve fibre layer parameters in non-glaucomatous eyes","volume":"97","author":"Tham","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib30","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/archophthalmol.2010.58","article-title":"African descent and glaucoma evaluation study (ADAGES): III. Ancestry differences in visual function in healthy eyes","volume":"128","author":"Racette","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.0006-341X.2000.00645.x","article-title":"A\u00a0note on robust variance estimation for cluster-correlated data","volume":"56","author":"Williams","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.ophtha.2014.06.047_bib32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/biostatistics\/3.3.421","article-title":"Distribution-free ROC analysis using binary regression techniques","volume":"3","author":"Alonzo","year":"2002","journal-title":"Biostatistics"},{"key":"10.1016\/j.ophtha.2014.06.047_bib33","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1167\/iovs.05-1441","article-title":"A\u00a0statistical approach to the evaluation of covariate effects on the receiver operating characteristic curves of diagnostic tests in glaucoma","volume":"47","author":"Medeiros","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"527","key":"10.1016\/j.ophtha.2014.06.047_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-8993(90)91061-K","article-title":"A\u00a0distinctive soma size gradient among catecholaminergic neurones of human retinae","volume":"10","author":"Mitrofanis","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.ophtha.2014.06.047_bib35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/cne.903180204","article-title":"Neurons of the human retina: a Golgi study","volume":"318","author":"Kolb","year":"1992","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib36","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1167\/iovs.13-11774","article-title":"Survey on amacrine cells coupling to retrograde-identified ganglion cells in the mouse retina","volume":"54","author":"Pang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib37","first-page":"741","article-title":"Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons","volume":"41","author":"Kerrigan-Baumrind","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib38","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1167\/iovs.10-5546","article-title":"Effect of disease severity and optic disc size on diagnostic accuracy of RTVue spectral domain optical coherence tomograph in glaucoma","volume":"52","author":"Rao","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib39","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1167\/iovs.13-11676","article-title":"Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma","volume":"54","author":"Lisboa","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib40","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1167\/iovs.10-5718","article-title":"Sensitivity loss in early glaucoma can be mapped to an enlargement of the area of complete spatial summation","volume":"51","author":"Redmond","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib41","first-page":"1774","article-title":"Scaling the hill of vision: the physiological relationship between light sensitivity and ganglion cell numbers","volume":"41","author":"Garway-Heath","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1442-9071.2012.02770.x","article-title":"\u2018Structure-function relationship\u2019 in glaucoma: past thinking and current concepts","volume":"40","author":"Malik","year":"2012","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.06.047_bib43","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1167\/iovs.12-11467","article-title":"The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells","volume":"54","author":"Tatham","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.06.047_bib44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ophtha.2012.09.055","article-title":"Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter","volume":"120","author":"Chauhan","year":"2013","journal-title":"Ophthalmology"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014005818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014005818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T08:23:16Z","timestamp":1538295796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642014005818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0161642014005818"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2014.06.047","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}