{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:17:04Z","timestamp":1788157024996,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.ophtha.2014.08.024","type":"journal-article","created":{"date-parts":[[2014,10,11]],"date-time":"2014-10-11T07:00:39Z","timestamp":1413010839000},"page":"265-273","source":"Crossref","is-referenced-by-count":28,"title":["Malignancy Risk in Patients with Inflammatory Eye Disease Treated with Systemic Immunosuppressive Therapy"],"prefix":"10.1016","volume":"122","author":[{"given":"William B.","family":"Yates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Vajdic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhua","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"McCluskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2014.08.024_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00163549","article-title":"The natural history of uveitis","volume":"14","author":"Nussenblatt","year":"1990","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/bjo.82.6.704","article-title":"Systemic corticosteroid therapy\u2014side effects and their management","volume":"82","author":"Stanbury","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0002-9394(00)00659-0","article-title":"Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel","volume":"130","author":"Jabs","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib4","first-page":"492","article-title":"Malignancies associated with immunosuppressive or cytotoxic therapy","volume":"83","author":"Penn","year":"1978","journal-title":"Surgery"},{"key":"10.1016\/j.ophtha.2014.08.024_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1399-0012.1987.tb00671.x","article-title":"Risk factors for skin carcinogenesis in immunosuppressed kidney transplant recipients","volume":"1","author":"Kelly","year":"1987","journal-title":"Clin Transplant"},{"key":"10.1016\/j.ophtha.2014.08.024_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00002018-200023020-00002","article-title":"Post-transplant malignancy: the role of immunosuppression","volume":"23","author":"Penn","year":"2000","journal-title":"Drug Saf"},{"key":"10.1016\/j.ophtha.2014.08.024_bib7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00042307-200303000-00004","article-title":"Tumours after kidney transplantation","volume":"13","author":"Lutz","year":"2003","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1432-2277.2006.00330.x","article-title":"Post-transplant de novo malignancies in renal transplant recipients: the past and present","volume":"19","author":"Kauffman","year":"2006","journal-title":"Transpl Int"},{"key":"10.1016\/j.ophtha.2014.08.024_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0140-6736(07)61050-2","article-title":"Incidence of cancers in people with HIV\/AIDS compared with immunosuppressed transplant recipients: a meta-analysis","volume":"370","author":"Grulich","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ophtha.2014.08.024_bib10","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1001\/jama.296.23.2823","article-title":"Cancer incidence before and after kidney transplantation","volume":"296","author":"Vajdic","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ophtha.2014.08.024_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5694\/j.1326-5377.2006.tb00086.x","article-title":"Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985","volume":"184","author":"Staples","year":"2006","journal-title":"Med J Aust"},{"key":"10.1016\/j.ophtha.2014.08.024_bib12","first-page":"1676","article-title":"A\u00a0population based, case control study of non-Hodgkin's lymphoma in patients with rheumatoid arthritis","volume":"26","author":"Kamel","year":"1999","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib13","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1001\/archinte.165.20.2337","article-title":"The risk of lymphoma development in autoimmune diseases: a meta-analysis","volume":"165","author":"Zintzaras","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ophtha.2014.08.024_bib14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0039-6257(91)90186-J","article-title":"Immunosuppressive drugs in immune and inflammatory ocular disease","volume":"35","author":"Hemady","year":"1991","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib15","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ajo.2008.04.035","article-title":"Long-term risk of malignancy among patients treated with immunosuppressive agents for ocular inflammation: a critical assessment of the evidence","volume":"146","author":"Kempen","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib16","doi-asserted-by":"crossref","first-page":"b2480","DOI":"10.1136\/bmj.b2480","article-title":"Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study","volume":"339","author":"Kempen","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.ophtha.2014.08.024_bib17","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/S0161-6420(95)30835-4","article-title":"Systemic immunosuppressive therapy and the occurrence of malignancy in patients with ocular inflammatory disease","volume":"102","author":"Lane","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.024_bib18","series-title":"Advances in Ocular Immunology: Proceedings of the 6th International Symposium on the Immunology and Immunopathology of the Eye","first-page":"421","article-title":"Increased risk of malignancy in patients with uveitis treated with systemic immunosuppressive therapy","author":"Murray","year":"1994"},{"key":"10.1016\/j.ophtha.2014.08.024_bib19","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1046\/j.1365-2133.2002.04976.x","article-title":"Non-melanoma skin cancer risk in the Queensland renal transplant population","volume":"147","author":"Ramsay","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1182\/blood-2009-02-202507","article-title":"Immunosuppression and other risk factors for early and late non-Hodgkin lymphoma after kidney transplantation","volume":"114","author":"van Leeuwen","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ophtha.2014.08.024_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1869-5760-3-48","article-title":"Are patients with inflammatory eye disease treated with systemic immunosuppressive therapy at increased risk of malignancy?","volume":"3","author":"Yates","year":"2013","journal-title":"J\u00a0Ophthalmic Inflamm Infect"},{"key":"10.1016\/j.ophtha.2014.08.024_bib22","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1080\/03610920802255856","article-title":"Comparison of confidence intervals for a Poisson mean: further considerations","volume":"38","author":"Swift","year":"2009","journal-title":"Commun Stat Theory Methods"},{"key":"10.1016\/j.ophtha.2014.08.024_bib23","unstructured":"Breslow NE, Day NE. Statistical Methods in Cancer Research. vol. II: The Design and Analysis of Cohort Studies. Oxford, UK: Oxford Univ. Press; International Agency for Research on\u00a0Cancer; 1987:III-82-92. IARC Sci Publ. no. 82. Available\u00a0at:\u00a0http:\/\/www.iarc.fr\/en\/publications\/pdfs-online\/stat\/sp82\/. Accessed August 13, 2014."},{"key":"10.1016\/j.ophtha.2014.08.024_bib24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/01621459.1989.10478873","article-title":"Regression analysis of multivariate incomplete failure time data by modeling marginal distributions","volume":"84","author":"Wei","year":"1989","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.ophtha.2014.08.024_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-5573-5-7","article-title":"Methods for stratification of person-time and events\u2014a prerequisite for Poisson regression and SIR estimation","volume":"5","author":"Rostgaard","year":"2008","journal-title":"Epidemiol Perspect Innov [serial online]"},{"key":"10.1016\/j.ophtha.2014.08.024_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(89)91143-4","article-title":"Human papilloma virus infection and skin cancer in renal allograft recipients","volume":"1","author":"Barr","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.ophtha.2014.08.024_bib27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A\u00a0review of human carcinogens\u2014part B: biological agents","volume":"10","author":"Bouvard","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s100670170036","article-title":"Malignancy in Beh\u00e7et's disease: a report of 13 cases and a review of the literature","volume":"20","author":"Cengiz","year":"2001","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ophtha.2014.08.024_bib29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1136\/thx.52.10.892","article-title":"Risk of malignant neoplasms in patients with pulmonary sarcoidosis","volume":"52","author":"Seersholm","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.ophtha.2014.08.024_bib30","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/ard.2002.004721","article-title":"Cancer incidence among patients with ankylosing spondylitis in Sweden 1965-1995: a population based cohort study","volume":"62","author":"Feltelius","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ophtha.2014.08.024_bib31","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/art.21675","article-title":"Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis","volume":"54","author":"Baecklund","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ophtha.2014.08.024_bib32","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/art.34348","article-title":"Rates of malignancy associated with juvenile idiopathic arthritis and its treatment","volume":"64","author":"Beukelman","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ophtha.2014.08.024_bib33","series-title":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. A Review of Human Carcinogens. Part\u00a0A: Pharmaceuticals. vol 100A","year":"2012"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014007623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014007623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:25:52Z","timestamp":1746415552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642014007623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0161642014007623"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2014.08.024","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}