{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:13:06Z","timestamp":1790273586454,"version":"4.1.0"},"reference-count":138,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.ophtha.2014.08.046","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T19:32:58Z","timestamp":1413315178000},"page":"414-428","source":"Crossref","is-referenced-by-count":104,"title":["Management of Posterior Uveal Melanoma: Past, Present, and Future"],"prefix":"10.1016","volume":"122","author":[{"given":"Jerry A.","family":"Shields","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol L.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2014.08.046_bib1","series-title":"Intraocular Tumors: An Atlas and Textbook","first-page":"139","author":"Shields","year":"2008"},{"key":"10.1016\/j.ophtha.2014.08.046_bib2","series-title":"Das Sarcom des Uvealtractus","author":"Fuchs","year":"1882"},{"key":"10.1016\/j.ophtha.2014.08.046_bib3","series-title":"The Pathology of the Eye","volume":"Vol. 2","author":"Parsons","year":"1904"},{"key":"10.1016\/j.ophtha.2014.08.046_bib4","first-page":"754","article-title":"Diseases of the uveal tract","volume":"vol. 9","author":"Duke-Elder","year":"1966"},{"key":"10.1016\/j.ophtha.2014.08.046_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/eye.1997.61","article-title":"Uveal melanoma: the past, the present and the future","volume":"11","author":"Rennie","year":"1997","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ophtha.2014.08.046_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archopht.1964.00970020463004","article-title":"Lesions mistaken for malignant melanoma of the posterior uvea: a clinicopathologic analysis of 100 cases with\u00a0ophthalmoscopically visible lesions","volume":"72","author":"Ferry","year":"1964","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1001\/archopht.1973.01000040468004","article-title":"Lesions simulating malignant melanoma of the posterior uvea","volume":"89","author":"Shields","year":"1973","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/archopht.1974.03900060269004","article-title":"Improvements in the diagnosis of posterior uveal melanomas","volume":"91","author":"Shields","year":"1974","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00006982-200509000-00013","article-title":"Pseudomelanomas of the posterior uveal tract: the 2006 Taylor R. Smith Lecture","volume":"25","author":"Shields","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/ICU.0000000000000041","article-title":"Choroidal melanoma: clinical features, classification, and top ten pseudomelanomas","volume":"25","author":"Shields","year":"2014","journal-title":"Curr Opinion Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib11","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.1990.01070110084030","article-title":"Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. COMS report no. 1","volume":"108","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib12","first-page":"OP297","article-title":"The significance of the 32-P uptake test in the diagnosis of posterior uveal melanomas","volume":"79","author":"Shields","year":"1975","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib13","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0161-6420(78)35595-0","article-title":"Accuracy and limitations of the 32P test in the\u00a0diagnosis of ocular tumors: an analysis of 500 cases","volume":"85","author":"Shields","year":"1978","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00155680","article-title":"The reliability of radioactive phosphorus (32P) in the diagnosis of intraocular tumors; experience with 912 patients","volume":"56","author":"Lommatzsch","year":"1984","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib15","first-page":"49","article-title":"The use of the 32P test in the management of malignant melanoma of the choroid: a five-year follow-up study","volume":"83","author":"Hagler","year":"1977","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib16","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0161-6420(93)31418-1","article-title":"Fine-needle aspiration biopsy of suspected intraocular tumors. The 1992 Urwick Lecture","volume":"100","author":"Shields","year":"1993","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib17","first-page":"34","article-title":"Fine needle aspiration biopsy of solid intraocular tumors: indications, instrumentation and techniques","volume":"15","author":"Augsburger","year":"1984","journal-title":"Ophthalmic Surg"},{"key":"10.1016\/j.ophtha.2014.08.046_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0039-6257(85)90206-1","article-title":"Fine needle aspiration biopsy in ophthalmology","volume":"29","author":"Midena","year":"1985","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0161-6420(85)34068-X","article-title":"Fine needle aspiration biopsy in the diagnosis of intraocular cancer. Cytologic-histologic correlations","volume":"92","author":"Augsburger","year":"1985","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00004397-199303330-00012","article-title":"Fine-needle aspiration biopsy of suspected intraocular tumors","volume":"33","author":"Shields","year":"1993","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2014.08.046_bib21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archopht.125.8.1017","article-title":"Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases. The Deborah Iverson MD Lectureship","volume":"125","author":"Shields","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib22","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.ophtha.2006.05.042","article-title":"Fine-needle aspiration biopsy of iris tumors in 100 consecutive cases: technique and complications","volume":"113","author":"Shields","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ophtha.2011.08.046","article-title":"Multi-year follow-up of fine-needle aspiration biopsy in choroidal melanoma","volume":"119","author":"McCannel","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.sjopt.2012.01.005","article-title":"Fine needle aspiration biopsy of ophthalmic tumors","volume":"26","author":"Singh","year":"2012","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/ICU.0b013e32835ff001","article-title":"Fine-needle aspiration biopsy in the management of choroidal melanoma","volume":"24","author":"McCannel","year":"2013","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib26","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.ophtha.2006.02.048","article-title":"Transretinal choroidal tumor biopsy with a 25-gauge vitrector","volume":"113","author":"Sen","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/bjo.62.6.420","article-title":"Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells","volume":"62","author":"Zimmerman","year":"1978","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib28","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0002-9394(79)90348-9","article-title":"An evaluation of enucleation in the management of uveal melanomas","volume":"87","author":"Zimmerman","year":"1979","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib29","first-page":"1","article-title":"An evaluation of enucleation in the management of uveal melanomas","volume":"20","author":"Zimmerman","year":"1980","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2014.08.046_bib30","first-page":"760","article-title":"Inferred natural history of uveal melanoma","volume":"19","author":"McLean","year":"1980","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.08.046_bib31","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1001\/archopht.1977.04450090138012","article-title":"No-touch technique for intraocular malignant melanomas","volume":"9","author":"Fraunfelder","year":"1977","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib32","first-page":"39","article-title":"Enucleation with stabilization of intraocular pressure in the treatment of uveal melanomas","volume":"11","author":"Kramer","year":"1980","journal-title":"Ophthalmic Surg"},{"key":"10.1016\/j.ophtha.2014.08.046_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0161-6420(80)35200-7","article-title":"Observation of suspected choroidal and ciliary body melanomas for evidence of growth prior to enucleation","volume":"87","author":"Gass","year":"1980","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00918938","article-title":"Uveal melanoma: therapeutic consequences of doubling times and irradiation results; a review","volume":"16","author":"Manschot","year":"1992","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib35","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/bjo.2003.029058","article-title":"The Zimmerman-McLean-Foster hypothesis: 25 years later","volume":"88","author":"Singh","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib36","first-page":"416","article-title":"Treatment of malignant melanomas of the choroid by photocoagulation","volume":"97","author":"Meyer-Schwickerath","year":"1977","journal-title":"Trans Ophthalmol Soc U K"},{"key":"10.1016\/j.ophtha.2014.08.046_bib37","first-page":"412","article-title":"Xenon-arc photocoagulation of medium-sized malignant melanomas","volume":"16","author":"Orellana","year":"1984","journal-title":"Ann Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0002-9394(14)72432-8","article-title":"Comparison of xenon arc and argon laser photocoagulation in the treatment of choroidal melanomas","volume":"109","author":"Shields","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archopht.1995.01100030071024","article-title":"Transpupillary thermotherapy in choroidal melanomas","volume":"113","author":"Oosterhuis","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib40","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0161-6420(98)94008-8","article-title":"Transpupillary thermotherapy for choroidal melanoma: tumor control and visual results in 100 consecutive cases","volume":"105","author":"Shields","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/archopht.116.2.157","article-title":"Transpupillary thermotherapy: results in 50 patients with choroidal melanoma","volume":"116","author":"Oosterhuis","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/bjo.81.3.234","article-title":"Histopathological findings in human choroidal melanomas after transpupillary thermotherapy","volume":"81","author":"Journ\u00e9e-de Korver","year":"1997","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0161-6420(01)00902-2","article-title":"Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases: outcomes and limitations","volume":"109","author":"Shields","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib44","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/bjo.2007.132951","article-title":"Long-term results of primary transpupillary thermal therapy for the treatment of choroidal malignant melanoma","volume":"92","author":"Aaberg","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0002-9394(99)00063-X","article-title":"Transpupillary thermotherapy for small choroidal melanoma","volume":"128","author":"Godfrey","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib46","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1001\/archopht.117.11.1512","article-title":"Transpupillary thermotherapy as primary treatment for small choroidal melanomas","volume":"117","author":"Robertson","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib47","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/bjo.2007.133249","article-title":"Primary transpupillary thermotherapy of \u201csmall\u201d choroidal melanoma: is it safe?","volume":"92","author":"Singh","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib48","first-page":"44","article-title":"Primary transpupillary thermotherapy for choroidal melanoma: still a valuable treatment in properly selected cases","volume":"5","author":"Kligman","year":"2010","journal-title":"Retina Today"},{"key":"10.1016\/j.ophtha.2014.08.046_bib49","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/S0161-6420(84)34086-6","article-title":"Ten years experience with eye wall resection for uveal malignant melanomas","volume":"91","author":"Peyman","year":"1984","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib50","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0161-6420(79)35424-0","article-title":"Full-thickness eye wall resection of choroidal neoplasms","volume":"86","author":"Peyman","year":"1979","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib51","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/archopht.1974.01010010224008","article-title":"Local excision of choroidal malignant melanoma","volume":"92","author":"Peyman","year":"1974","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib52","series-title":"Intraocular Tumors: A Text and Atlas","first-page":"189","author":"Shields","year":"1992"},{"key":"10.1016\/j.ophtha.2014.08.046_bib53","first-page":"774","article-title":"Surgical approach to lamellar sclerouvectomy for posterior uveal melanomas: the 1986 Schoenberg Lecture","volume":"19","author":"Shields","year":"1988","journal-title":"Ophthalmic Surg"},{"key":"10.1016\/j.ophtha.2014.08.046_bib54","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0161-6420(91)32194-8","article-title":"Partial lamellar sclerouvectomy for ciliary body and choroidal tumors","volume":"98","author":"Shields","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib55","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/eye.1987.110","article-title":"Local resection versus enucleation in the management of choroidal melanoma","volume":"1","author":"Foulds","year":"1987","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ophtha.2014.08.046_bib56","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/01.iio.0000195862.71558.c8","article-title":"The role of eyewall resection in uveal melanoma management","volume":"46","author":"Damato","year":"2006","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2014.08.046_bib57","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.ophtha.2003.02.001","article-title":"Transscleral resection versus iodine brachytherapy for choroidal malignant melanomas 6 millimeters or more in thickness: a matched case-control study","volume":"110","author":"Kivela","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bjo.50.3.147","article-title":"Radiotherapy for malignant melanoma of the choroid","volume":"50","author":"Stallard","year":"1966","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib59","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3928\/1542-8877-19980501-08","article-title":"Radiation therapy for uveal melanoma","volume":"29","author":"Shields","year":"1998","journal-title":"Ophthalmic Surg Lasers"},{"key":"10.1016\/j.ophtha.2014.08.046_bib60","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0161-6420(94)31338-8","article-title":"Palladium 103 plaque radiotherapy for uveal melanoma. Clinical experience","volume":"101","author":"Finger","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib61","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1001\/archopht.118.9.1219","article-title":"Plaque radiotherapy for uveal melanoma: long-term visual outcome in 1106 consecutive patients","volume":"118","author":"Shields","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib62","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0002-9394(00)00385-8","article-title":"Plaque radiotherapy for management of ciliary body and choroidal melanoma with extraocular extension","volume":"130","author":"Gunduz","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib63","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/archopht.117.2.170","article-title":"Plaque radiotherapy of uveal melanoma with predominant ciliary body involvement","volume":"117","author":"Gunduz","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib64","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1001\/archopht.126.11.1515","article-title":"Plaque radiotherapy for juxtapapillary choroidal melanoma overhanging the optic disc in 141 consecutive patients","volume":"126","author":"Sagoo","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib65","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ophtha.2010.06.007","article-title":"Plaque radiotherapy for juxtapapillary choroidal melanoma: tumor control in 650 consecutive cases","volume":"118","author":"Sagoo","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib66","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1001\/archopht.125.9.1202","article-title":"Plaque radiotherapy for choroidal melanoma encircling the optic disc (circumpapillary choroidal melanoma)","volume":"125","author":"Sagoo","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib67","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1001\/jamaophthalmol.2014.111","article-title":"Plaque radiotherapy for juxtapapillary choroidal melanoma: treatment complications and visual outcomes in 650 consecutive cases","volume":"132","author":"Sagoo","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib68","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/bjo.78.2.109","article-title":"Impact of enucleation versus plaque radiotherapy in the management of juxtapapillary choroidal melanoma on patient survival","volume":"78","author":"DePotter","year":"1994","journal-title":"Brit J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib69","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/S0161-6420(02)01181-8","article-title":"Plaque radiotherapy for large posterior uveal melanomas (> or\u00a0= 8-mm thick) in 354 consecutive patients","volume":"109","author":"Shields","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib70","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0002-9394(02)02241-9","article-title":"Custom-designed plaque radiotherapy for nonresectable iris melanoma in 38 patients: tumor control and ocular complications","volume":"135","author":"Shields","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib71","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ophtha.2012.06.053","article-title":"Iris melanoma management with iodine-125 plaque radiotherapy in 144 patients: impact of melanoma-related glaucoma on outcomes","volume":"120","author":"Shields","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib72","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1001\/archopht.120.7.933","article-title":"Combined plaque radiotherapy and transpupillary thermotherapy for choroidal melanoma: tumor control and treatment complications in 270 consecutive patients","volume":"120","author":"Shields","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib73","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0161-6420(80)35212-3","article-title":"Proton beam irradiation. An alternative to enucleation for intraocular melanomas","volume":"87","author":"Gragoudas","year":"1980","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib74","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0161-6420(89)32738-2","article-title":"The risk of enucleation after proton beam irradiation of uveal melanoma","volume":"96","author":"Egan","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00006982-199401000-00010","article-title":"Macular uveal melanoma treated with proton beam irradiation. 10-year follow-up observation with histopathologic correlation","volume":"14","author":"Young","year":"1994","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib76","first-page":"43","article-title":"Long-term risk of local failure after proton therapy for choroidal\/ciliary body melanoma","volume":"100","author":"Gragoudas","year":"2002","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ophtha.2014.08.046_bib77","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1167\/iovs.06-0659","article-title":"Proton beam irradiation of uveal melanomas: the first 30 years. The Weisenfeld Lecture","volume":"47","author":"Gragoudas","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.08.046_bib78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/bjo.80.2.117","article-title":"Long term visual outcome of radiated uveal melanomas in eyes eligible for randomisation to enucleation versus brachytherapy","volume":"80","author":"Char","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib79","first-page":"171","article-title":"Long-term follow-up after uveal melanoma charged particle therapy","volume":"95","author":"Char","year":"1997","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ophtha.2014.08.046_bib80","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0360-3016(97)00494-X","article-title":"15 years experience with helium ion radiotherapy for uveal melanoma","volume":"39","author":"Castro","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ophtha.2014.08.046_bib81","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0002-9394(99)80238-4","article-title":"Ten-year follow-up of helium ion therapy for uveal melanoma","volume":"125","author":"Char","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib82","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/00006982-200510000-00009","article-title":"Intravitreal triamcinolone acetonide for radiation maculopathy after plaque radiotherapy for choroidal melanoma","volume":"25","author":"Shields","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib83","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IAE.0b013e31814b1b75","article-title":"Early macular morphological changes following plaque radiotherapy for uveal melanoma","volume":"28","author":"Horgan","year":"2008","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib84","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/IAE.0b013e31816b3192","article-title":"Periocular triamcinolone for prevention of macular edema after iodine 125 plaque radiotherapy of uveal melanoma","volume":"28","author":"Horgan","year":"2008","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib85","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.ophtha.2009.01.051","article-title":"Periocular triamcinolone for prevention of macular edema after plaque radiotherapy of uveal melanoma: a randomized controlled trial","volume":"116","author":"Horgan","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib86","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/ICU.0b013e3283386687","article-title":"Classification and treatment of radiation maculopathy","volume":"21","author":"Horgan","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib87","doi-asserted-by":"crossref","first-page":"228","DOI":"10.5301\/ejo.5000352","article-title":"Monthly intravitreal bevacizumab for macular edema after iodine-125 plaque radiotherapy of uveal melanoma","volume":"24","author":"Mashayekhi","year":"2014","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib88","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ophtha.2013.08.039","article-title":"Intravitreal bevacizumab injection at 4-month intervals for prevention of macular edema following plaque radiotherapy of uveal melanoma","volume":"121","author":"Shah","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib89","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/bjo.2004.052159","article-title":"Laser photocoagulation for radiation retinopathy after ophthalmic plaque radiation therapy","volume":"89","author":"Finger","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib90","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1097\/IAE.0b013e3182437e70","article-title":"Sector laser photocoagulation for the prevention of macular edema following plaque radiotherapy for uveal melanoma","volume":"32","author":"Materin","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib91","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ohc.2004.11.004","article-title":"The Collaborative Ocular Melanoma Study","volume":"18","author":"Singh","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"key":"10.1016\/j.ophtha.2014.08.046_bib92","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/archopht.124.2.226","article-title":"Quality of life after iodine 125 brachytherapy vs enucleation for choroidal melanoma: 5-year results from the Collaborative Ocular Melanoma Study: COMS QOLS report no. 3","volume":"124","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib93","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1001\/archopht.1997.01100160707007","article-title":"Factors predictive of growth and treatment of small choroidal melanoma: COMS report no. 5","volume":"115","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib94","first-page":"779","article-title":"The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma II: initial mortality findings. COMS report no. 10","volume":"126","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib95","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archopht.119.7.969","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma. III: Initial mortality findings. COMS report no. 18","volume":"119","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib96","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.124.12.1684","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report no. 28","volume":"124","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib97","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ajo.2004.07.006","article-title":"Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report no. 24","volume":"138","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib98","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1001\/archopht.116.5.645","article-title":"Choroidal nevi in a white population: The Blue Mountains Eye Study","volume":"116","author":"Sumich","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib99","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0161-6420(03)00078-2","article-title":"Incidence of uveal melanoma in the United States: 1973\u20131997","volume":"110","author":"Singh","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib100","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.ophtha.2005.06.011","article-title":"Estimating the risk of malignant transformation of a choroidal nevus","volume":"112","author":"Singh","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib101","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0161-6420(95)30864-0","article-title":"Risk factors for growth and metastasis of small choroidal melanocytic lesions","volume":"102","author":"Shields","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib102","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archopht.118.3.360","article-title":"Combination of clinical factors predictive of growth of small choroidal melanocytic tumors","volume":"118","author":"Shields","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib103","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/archophthalmol.2009.151","article-title":"Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases","volume":"127","author":"Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib104","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0161-6420(00)00182-2","article-title":"Tumor doubling times in metastatic malignant melanoma of the uvea: tumor progression before and after treatment","volume":"107","author":"Eskelin","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib105","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0161-6420(00)00607-2","article-title":"Uveal melanoma: implications of tumor doubling time [letter]","volume":"108","author":"Singh","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib106","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0161-6420(00)00608-4","article-title":"In reply to: Singh AD. Uveal melanoma: implications of tumor doubling time","volume":"108","author":"Eskelin","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib107","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archophthalmol.2009.208","article-title":"Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes","volume":"127","author":"Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib108","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0140-6736(96)90736-9","article-title":"Prognostic implications of monosomy 3 in uveal melanoma","volume":"347","author":"Prescher","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ophtha.2014.08.046_bib109","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1167\/iovs.06-0101","article-title":"Clinical and cytogenetic analyses in uveal melanoma","volume":"47","author":"Kilic","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.08.046_bib110","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1158\/1078-0432.CCR-10-2076","article-title":"Genotypic profiling of 452 choroidal melanomas with multiplex ligation-dependent probe amplification","volume":"16","author":"Damato","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ophtha.2014.08.046_bib111","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ophtha.2010.05.023","article-title":"Prognosis of uveal melanoma in 500 cases using genetic testing of needle aspiration biopsy specimens","volume":"118","author":"Shields","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib112","first-page":"2578","article-title":"Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities","volume":"63","author":"Tschentscher","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ophtha.2014.08.046_bib113","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1158\/0008-5472.CAN-04-1750","article-title":"Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death","volume":"64","author":"Onken","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ophtha.2014.08.046_bib114","first-page":"1892","article-title":"Heterogeneity of monosomy 3 in fine needle aspiration biopsy of choroidal melanoma","volume":"19","author":"Chang","year":"2013","journal-title":"Mol Vis [serial online]"},{"key":"10.1016\/j.ophtha.2014.08.046_bib115","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.ajo.2009.07.004","article-title":"Molecular prognostic testing and individualized patient care in uveal melanoma","volume":"148","author":"Harbour","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib116","series-title":"AJCC Cancer Staging Manual","first-page":"547","year":"2010"},{"key":"10.1016\/j.ophtha.2014.08.046_bib117","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/j.ophtha.2013.03.012","article-title":"American Joint Committee on Cancer classification of posterior uveal melanoma (tumor size category) predicts prognosis in 7731 patients","volume":"120","author":"Shields","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib118","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1200\/JCO.2012.45.2771","article-title":"Staging of ciliary body and choroidal melanomas based on anatomic extent","volume":"31","author":"Kujala","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib119","first-page":"177","article-title":"Lack of complications of the hydroxyapatite orbital implant in 250 consecutive cases","volume":"91","author":"Shields","year":"1993","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ophtha.2014.08.046_bib120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ophtha.2006.08.030","article-title":"Experience with the polymer-coated hydroxyapatite implant following enucleation in 126 patients","volume":"114","author":"Shields","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib121","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archophthalmol.2009.396","article-title":"Harvesting fresh tumor tissue from enucleated eyes: the 2008 Jack S. Guyton Lecture","volume":"128","author":"Shields","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib122","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/bjophthalmol-2013-304501","article-title":"Trans-scleral local resection of toxic choroidal melanoma after proton beam radiotherapy","volume":"98","author":"Konstantinidis","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib123","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/IAE.0b013e31827f65c8","article-title":"Choroidal melanoma: does endoresection prevent neovascular glaucoma in patients treated with proton beam irradiation?","volume":"33","author":"Cassoux","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib124","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00002341-200109000-00010","article-title":"Experience with eyelid-sparing orbital exenteration: the 2000 Tullos O. Coston Lecture","volume":"17","author":"Shields","year":"2001","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2014.08.046_bib125","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1167\/iovs.13-12195","article-title":"Genomic profile of 320 uveal melanoma cases: chromosome 8p loss and metastatic outcome","volume":"54","author":"Ewens","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.08.046_bib126","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1167\/iovs.14-14550","article-title":"Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma","volume":"55","author":"Ewens","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.08.046_bib127","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10147-005-0532-7","article-title":"Early cancers of the skin: clinical, histopathological, and molecular characteristics","volume":"10","author":"Takata","year":"2005","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib128","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archderm.139.5.607","article-title":"Dermatologist detection and skin self-examination are associated with thinner melanomas: results from a survey of the Italian Multi-disciplinary Group on Melanoma","volume":"139","author":"Carli","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib129","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/IAE.0b013e31824d09a8","article-title":"Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8033 cases","volume":"32","author":"Shields","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.ophtha.2011.11.001","article-title":"Enhanced depth imaging optical coherence tomography of choroidal nevus in 104 cases","volume":"119","author":"Shah","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib131","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1001\/archophthalmol.2012.1135","article-title":"Enhanced depth imaging optical coherence tomography of small choroidal melanoma: comparison with choroidal nevus","volume":"130","author":"Shields","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib132","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/bjo.2007.130286","article-title":"Autofluorescence of choroidal melanoma in 51 cases","volume":"92","author":"Shields","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib133","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/IAE.0b013e318181b94b","article-title":"Autofluorescence of choroidal nevus in 64 cases","volume":"28","author":"Shields","year":"2008","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2014.08.046_bib134","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijrobp.2014.02.021","article-title":"Iodine 125 brachytherapy with vitrectomy and silicone oil in the treatment of uveal melanoma: 1-to-1 matched case-control series","volume":"89","author":"McCannel","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ophtha.2014.08.046_bib135","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.ophtha.2013.12.014","article-title":"A\u00a0molecular revolution in uveal melanoma: implications for patient care and targeted therapy","volume":"121","author":"Harbour","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.08.046_bib136","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/ICU.0000000000000051","article-title":"Recent developments in prognostic and predictive testing in uveal melanoma","volume":"25","author":"Field","year":"2014","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.08.046_bib137","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/gcc.22129","article-title":"Expanding the clinical phenotype of hereditary BAP1 cancer predisposition syndrome, reporting three new cases","volume":"53","author":"Pilarski","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.ophtha.2014.08.046_bib138","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1194472","article-title":"Frequent mutation of BAP1 in metastasizing uveal melanomas","volume":"330","author":"Harbour","year":"2010","journal-title":"Science"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014008197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014008197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T23:37:35Z","timestamp":1650411455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642014008197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":138,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0161642014008197"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2014.08.046","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}