{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:10:46Z","timestamp":1782623446135,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY12728"],"award-info":[{"award-number":["EY12728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY12358"],"award-info":[{"award-number":["EY12358"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ophtha.2014.09.012","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T10:06:42Z","timestamp":1416218802000},"page":"448-456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["The Effect of Donor Diabetes History on Graft Failure and Endothelial Cell Density 10 Years after Penetrating Keratoplasty"],"prefix":"10.1016","volume":"122","clinical-trial-number":[{"clinical-trial-number":"nct00006411","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jonathan H.","family":"Lass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya D.","family":"Riddlesworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L.","family":"Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Kollman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Benetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Francis W.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sugar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Terry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Soper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy W.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2014.09.012_bib1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00417-010-1573-9","article-title":"Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy","volume":"249","author":"Kim","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0420.1995.tb00659.x","article-title":"Effect of hyperglycemia duration on rabbit corneal thickness and endothelial ATPase activity","volume":"73","author":"Herse","year":"1995","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ophtha.2014.09.012_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/dmr.5610050102","article-title":"Biochemical manifestations of diabetes mellitus in microscopic layers of the cornea and retina","volume":"5","author":"Marano","year":"1989","journal-title":"Diabetes Metab Rev"},{"key":"10.1016\/j.ophtha.2014.09.012_bib4","first-page":"940","article-title":"Corneal endothelial morphology in the rat. Effects of aging, diabetes, and topical aldose reductase inhibitor treatment","volume":"29","author":"Meyer","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.09.012_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00003226-199503000-00014","article-title":"Changes of corneal redox state in diabetic animal models","volume":"14","author":"Shimazaki","year":"1995","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0021-5155(01)00458-0","article-title":"The corneal endothelium and thickness in type II diabetes mellitus","volume":"46","author":"Inoue","year":"2002","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0002-9394(14)75755-1","article-title":"Structural and functional studies of the corneal endothelium in diabetes mellitus","volume":"113","author":"Keoleian","year":"1992","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/archopht.1996.01100130007001","article-title":"Structure and function of the corneal endothelium in diabetes mellitus type I and type II","volume":"114","author":"Larsson","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.eye.6701868","article-title":"Differences in corneal thickness and corneal endothelium related to duration in diabetes","volume":"20","author":"Lee","year":"2006","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ophtha.2014.09.012_bib10","first-page":"1531","article-title":"Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II","volume":"25","author":"Modis","year":"2010","journal-title":"Histol Hostpathol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0002-9394(84)90120-X","article-title":"Corneal endothelial changes in type I and type II diabetes mellitus","volume":"98","author":"Schultz","year":"1984","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/112067210901900307","article-title":"Corneal endothelium in patients with diabetes mellitus: a historical cohort study","volume":"19","author":"Shenoy","year":"2009","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0002-9394(14)73367-7","article-title":"A\u00a0morphometric and fluorophotometric analysis of the corneal endothelium in type 1 diabetes mellitus and cystic fibrosis","volume":"100","author":"Lass","year":"1985","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib14","first-page":"691","article-title":"Discoveries in research on diabetic keratopathy","volume":"72","author":"Cisarik-Fredenburg","year":"2001","journal-title":"Optometry"},{"key":"10.1016\/j.ophtha.2014.09.012_bib15","first-page":"3","article-title":"Corneal function during normal and high serum glucose levels in diabetes","volume":"39","author":"McNamara","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.09.012_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000310482","article-title":"Corneal endothelial function in diabetes: a fluorophotometric study","volume":"208","author":"Ravalico","year":"1994","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.ophtha.2014.09.012_bib17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archopht.1996.01100130641001","article-title":"In vivo assessment of corneal endothelial function in diabetes mellitus","volume":"114","author":"Saini","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib18","first-page":"19","article-title":"Cornea stress test\u2014evaluation of corneal endothelial function in vivo by contact lens induced stress","volume":"45","author":"Saini","year":"1997","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00004397-199838020-00004","article-title":"The cornea in diabetes mellitus","volume":"38","author":"Sanchez-Thorin","year":"1998","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2014.09.012_bib20","first-page":"586","article-title":"Corneal hydration control in diabetes mellitus","volume":"36","author":"Weston","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2014.09.012_bib21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00003226-200207000-00004","article-title":"Assessment of induced corneal hypoxia in diabetic patients","volume":"21","author":"Ziadi","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib22","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/01.ico.0000230253.62730.85","article-title":"Major endothelial loss from corneas in organ culture: importance of second endothelial count","volume":"25","author":"Builles","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib23","series-title":"2014 Medical Standards. D1.000 Donor Eligibility Determination","first-page":"13","year":"2014"},{"key":"10.1016\/j.ophtha.2014.09.012_bib24","series-title":"National Diabetes Statistics Report","author":"Centers for Disease Control and Prevention","year":"2014"},{"key":"10.1016\/j.ophtha.2014.09.012_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.ico.0000151503.26695.f0","article-title":"Baseline donor characteristics in the Cornea Donor Study","volume":"24","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.ico.0000164832.69668.4b","article-title":"Clinical profile and early surgical complications in the Cornea Donor Study","volume":"25","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib27","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/ICO.0b013e3181a0a3e6","article-title":"Donor risk factors for graft failure in the Cornea Donor Study","volume":"28","author":"Sugar","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00003226-199303000-00001","article-title":"Design and methods of the Collaborative Corneal Transplantation Studies","volume":"12","year":"1993","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib29","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/j.ophtha.2013.08.044","article-title":"Donor age and factors related to endothelial cell loss 10 years after penetrating keratoplasty: Specular Microscopy Ancillary Study results","volume":"120","author":"Writing Committee for the Cornea Donor Study Research Group","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.09.012_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ophtha.2008.01.004","article-title":"Donor age and corneal endothelial cell loss 5 years after successful cornea transplantation: Specular Microscopy Ancillary Study results","volume":"115","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.09.012_bib31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ophtha.2004.10.045","article-title":"An evaluation of image quality and accuracy of eye bank measurement of donor cornea endothelial cell density in the Specular Microscopy Ancillary Study","volume":"112","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2014.09.012_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/02713680500536738","article-title":"Specular Microscopy Ancillary Study methods for donor endothelial cell density determination of Cornea Donor Study images","volume":"31","author":"Benetz","year":"2006","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ophtha.2014.09.012_bib33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"10.1016\/j.ophtha.2014.09.012_bib34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/biomet\/80.3.557","article-title":"Checking the Cox model with cumulative sums of martingale-based residuals","volume":"80","author":"Lin","year":"1993","journal-title":"Biometrika"},{"key":"10.1016\/j.ophtha.2014.09.012_bib35","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF00167879","article-title":"Endothelial barrier function after phacoemulsification: a comparison between diabetic and non-diabetic patients","volume":"229","author":"Goebbels","year":"1991","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib36","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/ICO.0b013e31820142d9","article-title":"Corneal endothelial cell changes associated with cataract surgery in patients with type 2 diabetes mellitus","volume":"30","author":"Hugod","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib37","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/ICO.0b013e3181eadb4b","article-title":"Endothelial cell loss and central corneal thickness in patients with and without diabetes after manual small incision cataract surgery","volume":"30","author":"Mathew","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib38","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1001\/archopht.122.7.966","article-title":"Corneal changes after small-incision cataract surgery in patients with diabetes mellitus","volume":"122","author":"Morikubo","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib39","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/archopht.121.8.1087","article-title":"Risk factors for various causes of failure in initial corneal grafts","volume":"121","author":"Price","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib40","first-page":"14","article-title":"Specular microscopy of the corneal endothelial cells in diabetes [in Chinese]","volume":"30","author":"Dong","year":"1994","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"10.1016\/j.ophtha.2014.09.012_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2008-1035450","article-title":"Confocal microscopy of the cornea in patients with diabetes [in German]","volume":"206","author":"Frueh","year":"1995","journal-title":"Klin Monbl Augenheilkd"},{"key":"10.1016\/j.ophtha.2014.09.012_bib42","first-page":"647","article-title":"The corneal endothelium of diabetic patients. A study using specular microscopy [in French]","volume":"10","author":"de la Messeliere","year":"1987","journal-title":"J\u00a0Fr Ophtalmol"},{"key":"10.1016\/j.ophtha.2014.09.012_bib43","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/ICO.0000000000000262","article-title":"Diabetes mellitus increases risk of unsuccessful graft preparation in Descemet membrane endothelial keratoplasty: a multicenter study","volume":"33","author":"Greiner","year":"2014","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2014.09.012_bib44","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.ophtha.2013.06.038","article-title":"Reproducibility of graft preparations in Descemet\u2019s membrane endothelial keratoplasty","volume":"120","author":"Schlotzer-Schrehardt","year":"2013","journal-title":"Ophthalmology"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014008604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642014008604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:05:52Z","timestamp":1758981952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642014008604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0161642014008604"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2014.09.012","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Donor Diabetes History on Graft Failure and Endothelial Cell Density 10 Years after Penetrating Keratoplasty","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2014.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}