{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:45:50Z","timestamp":1774928750589,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ophtha.2015.09.047","type":"journal-article","created":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T01:16:40Z","timestamp":1446254200000},"page":"408-414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes"],"prefix":"10.1016","volume":"123","clinical-trial-number":[{"clinical-trial-number":"nct00221897","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00221923","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Anna L.","family":"Silverman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naama","family":"Hammel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naira","family":"Khachatryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Sharpsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe A.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Girkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Liebmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Zangwill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2015.09.047_bib1","doi-asserted-by":"crossref","first-page":"e76590","DOI":"10.1371\/journal.pone.0076590","article-title":"The relationship between visual field index and estimated number of retinal ganglion cells in glaucoma","volume":"8","author":"Marvasti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2015.09.047_bib2","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.ophtha.2012.12.048","article-title":"Ability of cirrus high-definition spectral-domain optical coherence tomography clock-hour, deviation, and thickness maps in detecting photographic retinal nerve fiber layer abnormalities","volume":"120","author":"Hwang","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2015.09.047_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.preteyeres.2007.08.001","article-title":"A\u00a0framework for comparing structural and functional measures of glaucomatous damage","volume":"26","author":"Hood","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2015.09.047_bib4","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1167\/iovs.13-11676","article-title":"Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma","volume":"54","author":"Lisboa","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2015.09.047_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0002-9394(02)01930-X","article-title":"Structure and function evaluation (SAFE): II. Comparison of optic disk and visual field characteristics","volume":"135","author":"Johnson","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/08820530009037873","article-title":"The relationship between structural and functional alterations in glaucoma: a review","volume":"15","author":"Johnson","year":"2000","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib7","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1167\/iovs.04-0227","article-title":"Neural losses correlated with visual losses in clinical perimetry","volume":"45","author":"Harwerth","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2015.09.047_bib8","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1167\/iovs.12-10345","article-title":"The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change","volume":"53","author":"Medeiros","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2015.09.047_bib9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1364\/OE.11.000889","article-title":"Performance of Fourier domain vs. time domain optical coherence tomography","volume":"11","author":"Leitgeb","year":"2003","journal-title":"Opt Express"},{"key":"10.1016\/j.ophtha.2015.09.047_bib10","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ophtha.2009.04.013","article-title":"Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study","volume":"116","author":"Leung","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2015.09.047_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/IJG.0b013e3181c4b0c7","article-title":"Retinal nerve fiber layer thickness in normals measured by spectral domain OCT","volume":"19","author":"Bendschneider","year":"2010","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2015.09.047_bib12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/IJG.0000000000000152","article-title":"Normative databases for imaging instrumentation","volume":"24","author":"Realini","year":"2015","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2015.09.047_bib13","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.ophtha.2012.03.044","article-title":"Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: patterns of retinal nerve fiber layer progression","volume":"119","author":"Leung","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2015.09.047_bib14","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archophthalmol.2010.204","article-title":"Spectral-domain optical coherence tomography for detection of localized retinal nerve fiber layer defects in patients with open-angle glaucoma","volume":"128","author":"Kim","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib15","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archophthalmol.2009.187","article-title":"The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data","volume":"127","author":"Sample","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/archophthalmol.2010.58","article-title":"African Descent and Glaucoma Evaluation Study (ADAGES): III. Ancestry differences in visual function in healthy eyes","volume":"128","author":"Racette","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ajo.2010.06.041","article-title":"Agreement among spectral-domain optical coherence tomography instruments for assessing retinal nerve fiber layer thickness","volume":"151","author":"Leite","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/archopthalmol.2011.1576","article-title":"Effect of race, age, and axial length on optic nerve head parameters and retinal nerve fiber layer thickness measured by Cirrus HD-OCT","volume":"130","author":"Knight","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.ophtha.2015.09.047_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/IJG.0b013e3182741cc4","article-title":"Diagnostic ability of spectral-domain versus time-domain optical coherence tomography in preperimetric glaucoma","volume":"23","author":"Jeoung","year":"2014","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2015.09.047_bib21","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.ophtha.2009.06.012","article-title":"Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diagnosing early to moderate glaucoma","volume":"116","author":"Chang","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2015.09.047_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/archopht.122.1.22","article-title":"Racial differences in optic disc topography: baseline results from the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study","volume":"122","author":"Zangwill","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2015.09.047_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ophtha.2009.06.062","article-title":"Comparison of the diagnostic capability of the Heidelberg Retina Tomographs 2 and 3 for glaucoma in the Indian population","volume":"117","author":"Rao","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2015.09.047_bib24","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1167\/iovs.10-6698","article-title":"The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral-domain optical coherence tomography","volume":"52","author":"Girkin","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642015011446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642015011446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:06:06Z","timestamp":1758981966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642015011446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0161642015011446"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2015.09.047","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2015.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}