{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:14:59Z","timestamp":1776435299284,"version":"3.51.2"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","aaojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ophtha.2016.06.033","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T22:33:42Z","timestamp":1470522822000},"page":"2066-2076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Alterations of the Lamina Cribrosa Are Associated with Peripapillary Retinoschisis in Glaucoma and Pachychoroid Spectrum Disease"],"prefix":"10.1016","volume":"123","author":[{"given":"Jae Hyung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Young Lopilly","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Ki","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2016.06.033_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/IIO.0000000000000025","article-title":"Optic disc pit maculopathy: a review and update on imaging and treatment","volume":"54","author":"Shah","year":"2014","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.ophtha.2016.06.033_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ajo.2014.06.001","article-title":"Pathogenesis and treatment of maculopathy associated with cavitary optic disc anomalies","volume":"158","author":"Jain","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.62.6.389","article-title":"Pit-like changes of the optic nerve head in open-angle glaucoma","volume":"62","author":"Radius","year":"1978","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3129\/can j ophthalmol.i07-027","article-title":"Acute visual loss due to serous retinal detachment from acquired optic pit may be a rare presentation of primary open-angle glaucoma","volume":"42","author":"Rath","year":"2007","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3341\/kjo.2011.25.6.455","article-title":"Optic disc pit with peripapillary retinoschisis presenting as a localized retinal nerve fiber layer defect","volume":"25","author":"Song","year":"2011","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib6","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.ophtha.2014.06.005","article-title":"Microstructure of the optic disc pit in open-angle glaucoma","volume":"121","author":"Choi","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2016.06.033_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10384-014-0330-8","article-title":"Bilateral papillomacular retinoschisis and macular detachment accompanied by focal lamina cribrosa defect in glaucomatous eyes","volume":"58","author":"Yoshitake","year":"2014","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib8","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/IAE.0b013e3182953df4","article-title":"Pachychoroid pigment epitheliopathy","volume":"33","author":"Warrow","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2016.06.033_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/IAE.0000000000000331","article-title":"Pachychoroid neovasculopathy","volume":"35","author":"Pang","year":"2015","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2016.06.033_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ophtha.2011.07.033","article-title":"Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma","volume":"119","author":"Park","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2016.06.033_bib11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ophtha.2012.09.051","article-title":"Diagnostic capability of lamina cribrosa thickness by enhanced depth imaging and factors affecting thickness in patients with glaucoma","volume":"120","author":"Park","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2016.06.033_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1167\/iovs.12-10329","article-title":"Changes in the lamina and prelamina after intraocular pressure reduction in patients with primary open-angle glaucoma and acute primary angle-closure","volume":"55","author":"Park","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.033_bib13","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1167\/iovs.13-12742","article-title":"Recent structural alteration of the peripheral lamina cribrosa near the location of disc hemorrhage in glaucoma","volume":"55","author":"Lee","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.033_bib14","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1167\/iovs.13-13014","article-title":"Factors associated with focal lamina cribrosa defects in glaucoma","volume":"54","author":"Park","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.033_bib15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ophtha.2013.08.018","article-title":"Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss","volume":"121","author":"Tatham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2016.06.033_bib16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1001\/archopthalmol.2011.1309","article-title":"In\u00a0vivo evaluation of focal lamina cribrosa defects in glaucoma","volume":"130","author":"Kiumehr","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-211036","article-title":"Laser treatment of macular retinoschisis due to acquired optic nerve pit from glaucoma","volume":"2015","author":"Prinzi","year":"2015","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.ophtha.2016.06.033_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/aos.12568","article-title":"Spontaneous resolution of peripapillary retinoschisis associated with glaucomatous optic neuropathy","volume":"93","author":"Inoue","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/OPX.0b013e3181d1dad5","article-title":"Peripapillary schisis with serous detachment in advanced glaucoma","volume":"87","author":"Farjad","year":"2010","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.033_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3928\/23258160-20150101-21","article-title":"Vitrectomy without gas tamponade for macular retinoschisis associated with normal-tension glaucoma","volume":"46","author":"Orazbekov","year":"2015","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.ophtha.2016.06.033_bib21","doi-asserted-by":"crossref","first-page":"e90129","DOI":"10.1371\/journal.pone.0090129","article-title":"Peripapillary retinoschisis in glaucomatous eyes","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2016.06.033_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-009469","article-title":"Peripapillary and macular retinoschisis in a patient with pseudoexfoliation glaucoma","volume":"2013","author":"Ornek","year":"2013","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.ophtha.2016.06.033_bib23","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ajo.2006.10.054","article-title":"Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure","volume":"143","author":"Kahook","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib24","first-page":"587","article-title":"Pathogenesis of disciform detachment of the neuroepithelium, II: idiopathic central serous chorioretinopathy","volume":"63","author":"Gass","year":"1967","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib25","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/archopht.1994.01090200063023","article-title":"Digital indocyanine green videoangiography of central serous chorioretinopathy","volume":"112","author":"Guyer","year":"1994","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib26","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ajo.2013.12.029","article-title":"Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy","volume":"157","author":"Razavi","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib27","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.ophtha.2012.02.021","article-title":"Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy","volume":"119","author":"Jirarattanasopa","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2016.06.033_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2016.06.033_bib29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.exer.2007.05.005","article-title":"Predicted extension, compression and shearing of optic nerve head tissues","volume":"85","author":"Sigal","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ophtha.2016.06.033_bib30","first-page":"513","article-title":"Is there a potential defect in the blood-retinal barrier at the choroidal level of the optic nerve canal?","volume":"12","author":"Cohen","year":"1973","journal-title":"Invest Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib31","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/archopht.1975.01010020703008","article-title":"Is there a blood-brain barrier at the optic nerve head?","volume":"93","author":"Tso","year":"1975","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1001\/archopht.1971.00990050602014","article-title":"Ocular localization of sodium fluorescein. Effects of administration in rabbit and monkey","volume":"85","author":"Grayson","year":"1971","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1755-3768.1975.tb00398.x","article-title":"The distribution of intravenously administered peroxidase in the optic nerve head of rabbit and monkey","volume":"53","author":"Flage","year":"1975","journal-title":"Acta Ophthalmol"},{"issue":"Suppl 2","key":"10.1016\/j.ophtha.2016.06.033_bib34","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.survophthal.2007.08.005","article-title":"Does the blood-brain barrier play a role in glaucoma?","volume":"52","author":"Grieshaber","year":"2007","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.033_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/OPTH.S75448","article-title":"Isolated posterior uveal effusion: expanding the spectrum of the uveal effusion syndrome","volume":"9","author":"Pautler","year":"2014","journal-title":"Clin Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642016305012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642016305012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T15:52:46Z","timestamp":1749052366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642016305012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0161642016305012"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2016.06.033","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations of the Lamina Cribrosa Are Associated with Peripapillary Retinoschisis in Glaucoma and Pachychoroid Spectrum Disease","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2016.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}