{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:06:56Z","timestamp":1790276816060,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","aaojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ophtha.2016.06.048","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T13:55:40Z","timestamp":1470232540000},"page":"2183-2195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Characterization of Chorioretinopathy Associated with Mitochondrial Trifunctional Protein Disorders"],"prefix":"10.1016","volume":"123","author":[{"given":"Erin A.","family":"Boese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieraj","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catie L.","family":"Schlechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary O.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-037X","authenticated-orcid":false,"given":"Simon S.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-0815","authenticated-orcid":false,"given":"Rachel C.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2592-8393","authenticated-orcid":false,"given":"David","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-0367","authenticated-orcid":false,"given":"Richard G.","family":"Weleber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0897-8268","authenticated-orcid":false,"given":"Melanie B.","family":"Gillingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-6599","authenticated-orcid":false,"given":"Mark E.","family":"Pennesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2016.06.048_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01799383","article-title":"Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of a new inborn error of mitochondrial fatty acid beta-oxidation","volume":"13","author":"Wanders","year":"1990","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.ophtha.2016.06.048_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.physiol.64.082201.154705","article-title":"Fatty acid oxidation disorders","volume":"64","author":"Rinaldo","year":"2002","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1651-2227.1999.tb01089.x","article-title":"Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency","volume":"88","author":"Tyni","year":"1999","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ophtha.2016.06.048_bib4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/BF01799932","article-title":"Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency","volume":"14","author":"Przyrembel","year":"1991","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.ophtha.2016.06.048_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1542\/peds.109.1.99","article-title":"Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: clinical presentation and follow-up of 50 patients","volume":"109","author":"Boer den","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.ophtha.2016.06.048_bib6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ymgme.2005.06.001","article-title":"Effect of optimal dietary therapy upon visual function in children with long-chain 3-hydroxyacyl CoA dehydrogenase and trifunctional protein deficiency","volume":"86","author":"Gillingham","year":"2005","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.ophtha.2016.06.048_bib7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1096-7192(03)00073-8","article-title":"Optimal dietary therapy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency","volume":"79","author":"Gillingham","year":"2003","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.ophtha.2016.06.048_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/02713689808951227","article-title":"Ophthalmic pathology in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation","volume":"17","author":"Tyni","year":"1998","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ophtha.2016.06.048_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01958956","article-title":"Peripheral sensory-motor polyneuropathy, pigmentary retinopathy, and fatal cardiomyopathy in long-chain 3-hydroxy-acyl-CoA dehydrogenase deficiency","volume":"151","author":"Bertini","year":"1992","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ophtha.2016.06.048_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ymgme.2012.02.015","article-title":"Observations regarding retinopathy in mitochondrial trifunctional protein deficiencies","volume":"106","author":"Fletcher","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.ophtha.2016.06.048_bib11","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0161-6420(98)95019-9","article-title":"Ophthalmologic findings in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation","volume":"105","author":"Tyni","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2016.06.048_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000334874","article-title":"Refined staging for chorioretinopathy in long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency","volume":"48","author":"Tyni","year":"2012","journal-title":"Ophthal Res"},{"key":"10.1016\/j.ophtha.2016.06.048_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0887-8994(96)00021-5","article-title":"The clinical spectrum of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency","volume":"14","author":"Pons","year":"1996","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib14","series-title":"Acylcarnitine Analysis by Tandem Mass Spectrometry","author":"Smith","year":"2001"},{"key":"10.1016\/j.ophtha.2016.06.048_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1167\/tvst.4.2.14","article-title":"VFMA: topographic analysis of sensitivity data from full-field static perimetry","volume":"4","author":"Weleber","year":"2015","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1167\/iovs.08-2229","article-title":"Comparison of the new perimetric GATE strategy with conventional full-threshold and SITA standard strategies","volume":"50","author":"Schiefer","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.048_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bjophthalmol-2013-304535","article-title":"Validation of a new static perimetric thresholding strategy (GATE)","volume":"99","author":"Luithardt","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib18","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1364\/OE.20.004710","article-title":"Split-spectrum amplitude-decorrelation angiography with optical coherence tomography","volume":"20","author":"Jia","year":"2012","journal-title":"Optics Express"},{"key":"10.1016\/j.ophtha.2016.06.048_bib19","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1364\/OL.40.002305","article-title":"Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system","volume":"40","author":"Gao","year":"2015","journal-title":"Opt Lett"},{"key":"10.1016\/j.ophtha.2016.06.048_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-014-9473-7","article-title":"ISCEV Standard for full-field clinical electroretinography (2015 update)","volume":"130","author":"McCulloch","year":"2015","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jcrs.2004.01.014","article-title":"Visual acuity measurements","volume":"30","author":"Holladay","year":"2004","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2016.06.048_bib22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/bjo.63.2.90","article-title":"Bilateral symmetry of vision disorders in typical retinitis pigmentosa","volume":"63","author":"Massof","year":"1979","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib23","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1097\/IAE.0b013e318296b12f","article-title":"Outer retinal tubulation in degenerative retinal disorders","volume":"33","author":"Goldberg","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2016.06.048_bib24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1001\/jamaophthalmol.2016.0874","article-title":"Optical coherence tomography angiography in choroideremia: correlating choriocapillaris loss with overlying degeneration","volume":"134","author":"Jain","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib25","first-page":"2384","article-title":"Contribution of microglia as passenger leukocytes to the fate of intraocular neuronal retinal grafts","volume":"39","author":"Ma","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.048_bib26","doi-asserted-by":"crossref","first-page":"e0148022","DOI":"10.1371\/journal.pone.0148022","article-title":"Structure-Function modeling of optical coherence tomography and standard automated perimetry in the retina of patients with autosomal dominant retinitis pigmentosa","volume":"11","author":"Smith","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2016.06.048_bib27","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1167\/iovs.14-14007","article-title":"Patient-specific induced pluripotent stem cell-derived RPE cells: understanding the pathogenesis of retinopathy in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency","volume":"56","author":"Polinati","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2016.06.048_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1600-0420.2007.01121.x","article-title":"Ocular characteristics in 10 children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a cross-sectional study with\u00a0long-term follow-up","volume":"86","author":"Fahnehjelm","year":"2007","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib29","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0181-5512(08)74746-6","article-title":"Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency and choroidal neovascularization","volume":"31","author":"Stopek","year":"2008","journal-title":"J\u00a0Fr Ophtalmol"},{"key":"10.1016\/j.ophtha.2016.06.048_bib30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1203\/01.PDR.0000103931.80055.06","article-title":"General mitochondrial trifunctional protein (TFP) deficiency as a result of either alpha- or beta-subunit mutations exhibits similar phenotypes because mutations in either subunit alter TFP complex expression and subunit turnover","volume":"55","author":"Spiekerkoetter","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ophtha.2016.06.048_bib31","doi-asserted-by":"crossref","first-page":"29834","DOI":"10.1074\/jbc.M110.139493","article-title":"Evidence for physical association of mitochondrial fatty acid oxidation and oxidative phosphorylation complexes","volume":"285","author":"Wang","year":"2010","journal-title":"J\u00a0Biol Chem"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642016305784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642016305784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T13:25:54Z","timestamp":1536499554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642016305784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0161642016305784"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2016.06.048","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of Chorioretinopathy Associated with Mitochondrial Trifunctional Protein Disorders","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2016.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}