{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:12:06Z","timestamp":1788520326760,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","aaojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ophtha.2017.01.046","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T21:00:30Z","timestamp":1488920430000},"page":"896-902","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Foveal Hypoplasia in Patients with Stickler Syndrome"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-7122","authenticated-orcid":false,"given":"Itsuka","family":"Matsushita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-8725","authenticated-orcid":false,"given":"Takaaki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6177-549X","authenticated-orcid":false,"given":"Toshiaki","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Ohji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-0948","authenticated-orcid":false,"given":"Shunji","family":"Kusaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2017.01.046_bib1","first-page":"1083","article-title":"Variation in the vitreous phenotype of Stickler syndrome can be caused by different amino acid substitutions in the X position of the type II collagen Gly-X-Y triple helix","volume":"67","author":"Richards","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ophtha.2017.01.046_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0039-6257(02)00460-5","article-title":"Clinical variability of Stickler syndrome: role of exon 2 of the collagen COL2A1 gene","volume":"48","author":"Donoso","year":"2003","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib3","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.ophtha.2014.02.022","article-title":"Prevention of retinal detachment in Stickler syndrome: the Cambridge prophylactic cryotherapy protocol","volume":"121","author":"Fincham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.01.046_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00417-015-3125-9","article-title":"Giant premacular bursa: a novel finding of the posterior vitreous in two patients with Stickler syndrome type 1 revealed by swept-source optical coherence tomography","volume":"254","author":"Chen","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ajo.2012.05.004","article-title":"Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology","volume":"154","author":"Vajzovic","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajo.2015.09.023","article-title":"Development of retinal layers in prenatal human retina","volume":"161","author":"Hendrickson","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40942-015-0005-8","article-title":"A\u00a0review of optical coherence tomography angiography (OCTA)","volume":"1","author":"de Carlo","year":"2015","journal-title":"Int J Retina Vitreous"},{"key":"10.1016\/j.ophtha.2017.01.046_bib8","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/hgv.2016.18","article-title":"Novel mutations in the COL2A1 gene in Japanese patients with Stickler syndrome","volume":"3","author":"Kondo","year":"2016","journal-title":"Hum Genome Var"},{"key":"10.1016\/j.ophtha.2017.01.046_bib9","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.ophtha.2011.05.028","article-title":"Dynamics of human foveal development after premature birth","volume":"118","author":"Maldonado","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.01.046_bib10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/IAE.0b013e3181ed8dae","article-title":"Improved visualization of\u00a0Henle fiber layer by changing the measurement beam angle on optical coherence tomography","volume":"31","author":"Otani","year":"2011","journal-title":"Retina"},{"key":"10.1016\/j.ophtha.2017.01.046_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0161-6420(84)34247-6","article-title":"The morphological development of the human fovea","volume":"91","author":"Hendrickson","year":"1984","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.01.046_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.preteyeres.2013.01.005","article-title":"Adaptation of the central retina for high acuity vision: cones, the fovea and the vascular zone","volume":"35","author":"Provis","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ophtha.2017.01.046_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0042-6989(86)90143-4","article-title":"A\u00a0qualitative and quantitative analysis of the human fovea during development","volume":"26","author":"Yuodelis","year":"1986","journal-title":"Vision Res"},{"key":"10.1016\/j.ophtha.2017.01.046_bib14","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.ophtha.2011.01.028","article-title":"Structural grading of foveal hypoplasia using spectral-domain optical coherence tomography a predictor of visual acuity?","volume":"118","author":"Thomas","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.01.046_bib15","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archopht.126.7.907","article-title":"Visual insignificance of the foveal pit: reassessment of foveal hypoplasia as fovea plana","volume":"126","author":"Marmor","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib16","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1167\/iovs.13-13217","article-title":"Relationship between foveal cone specialization and pit morphology in albinism","volume":"55","author":"Wilk","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2017.01.046_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ejhg.2013.162","article-title":"Autosomal-dominant nystagmus, foveal hypoplasia and presenile cataract associated with a novel PAX6 mutation","volume":"22","author":"Thomas","year":"2014","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ophtha.2017.01.046_bib18","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ajo.2014.05.017","article-title":"Foveal structure-function correlation in children with history of retinopathy of prematurity","volume":"158","author":"Villegas","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib19","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.ophtha.2012.02.040","article-title":"Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity","volume":"119","author":"Wu","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.01.046_bib20","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1016\/j.ophtha.2015.07.024","article-title":"Familial exudative vitreoretinopathy: spectral-domain optical coherence tomography of the vitreoretinal interface, retina, and choroid","volume":"122","author":"Yonekawa","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.01.046_bib21","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1001\/jamaophthalmol.2015.1700","article-title":"Structural abnormalities of the inner macula in incontinentia pigmenti","volume":"133","author":"Basilius","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00417-008-1016-z","article-title":"Analysis of the vitreous membrane in a case of type 1 Stickler syndrome","volume":"247","author":"Yokoi","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/cne.10705","article-title":"VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: evidence of developmental hypoxia","volume":"462","author":"Sandercoe","year":"2003","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.ophtha.2017.01.046_bib24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3928\/23258160-20160808-06","article-title":"En face imaging of epiretinal membranes and the retinal nerve fiber layer using swept-source optical coherence tomography","volume":"47","author":"Greven","year":"2016","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.ophtha.2017.01.046_bib25","doi-asserted-by":"crossref","first-page":"E1461","DOI":"10.1002\/humu.21257","article-title":"Stickler syndrome and the vitreous phenotype: mutations in COL2A1 and COL11A1","volume":"31","author":"Richards","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ophtha.2017.01.046_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1086\/506478","article-title":"A\u00a0new autosomal recessive form of Stickler syndrome is caused by a mutation in the COL9A1 gene","volume":"79","author":"Van Camp","year":"2006","journal-title":"Am J Hum Genet"}],"updated-by":[{"DOI":"10.1016\/j.ophtha.2018.02.030","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000}}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642016324538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642016324538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T15:23:21Z","timestamp":1535988201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642016324538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0161642016324538"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2017.01.046","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ophtha.2018.02.030","asserted-by":"object"}]},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Foveal Hypoplasia in Patients with Stickler Syndrome","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2017.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}