{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:30:58Z","timestamp":1777649458794,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","aaojournal.org","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ophtha.2017.10.034","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T01:02:39Z","timestamp":1512176559000},"page":"505-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia"],"prefix":"10.1016","volume":"125","author":[{"given":"Marianne O.","family":"Price","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Fairchild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Francis W.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2017.10.034_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","article-title":"Global consensus on keratoconus and ectatic diseases","volume":"34","author":"Gomes","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2017.10.034_bib2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jcrs.2009.07.044","article-title":"Significance of the riboflavin film in corneal collagen crosslinking","volume":"36","author":"Wollensak","year":"2010","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib4","first-page":"1089","article-title":"Analysis of the effective dose of ultraviolet light in corneal cross-linking","volume":"9","author":"Zhang","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib5","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","article-title":"Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results","volume":"34","author":"Raiskup-Wolf","year":"2008","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ophtha.2013.10.028","article-title":"A\u00a0randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results","volume":"121","author":"Wittig-Silva","year":"2014","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ophtha.2017.10.034_bib7","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.ophtha.2017.03.052","article-title":"United States multicenter clinical trial of corneal collagen crosslinking for keratoconus treatment","volume":"124","author":"Hersh","year":"2017","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.ophtha.2017.10.034_bib8","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.ophtha.2017.05.036","article-title":"U.S. multicenter clinical trial of corneal collagen crosslinking for treatment of corneal ectasia after refractive surgery","volume":"124","author":"Hersh","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.10.034_bib9","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/01.ico.0000226359.26678.d1","article-title":"A\u00a0new method for grading the severity of keratoconus: the Keratoconus Severity Score (KSS)","volume":"25","author":"McMahon","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2017.10.034_bib10","first-page":"496","article-title":"Contact lens-assisted corneal cross-linking","volume":"31","author":"Kumar","year":"2015","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/ICO.0b013e318269059b","article-title":"Riboflavin\/ultraviolet a crosslinking of the paracentral cornea","volume":"32","author":"Koller","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2017.10.034_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/ICO.0000000000000723","article-title":"Efficacy of corneal cross-linking for the treatment of keratoconus: a systematic review and meta-analysis","volume":"35","author":"Meiri","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2017.10.034_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcrs.2014.09.033","article-title":"Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: ten year results","volume":"41","author":"Raiskup","year":"2015","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib14","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.ajo.2015.08.023","article-title":"Corneal cross-linking to halt the progression of keratoconus and corneal ectasia: seven-year follow-up","volume":"160","author":"O'Brart","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib15","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.jcrs.2010.06.067","article-title":"Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis","volume":"36","author":"Greenstein","year":"2010","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib16","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jcrs.2009.03.035","article-title":"Complication and failure rates after corneal crosslinking","volume":"35","author":"Koller","year":"2009","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00347-012-2682-0","article-title":"Complications of corneal crosslinking","volume":"110","author":"Seiler","year":"2013","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.ophtha.2017.10.034_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/ceo.12035","article-title":"Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus","volume":"41","author":"Viswanathan","year":"2013","journal-title":"Clin Experiment Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib19","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0161-6420(01)00624-8","article-title":"A\u00a0prospective, randomized comparison of the use versus non-use of topical corticosteroids after laser in situ keratomileusis","volume":"108","author":"Price","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.10.034_bib20","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jcrs.2007.06.036","article-title":"Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus","volume":"33","author":"Kymionis","year":"2007","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10792-011-9489-x","article-title":"Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus","volume":"31","author":"Yuksel","year":"2011","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib22","first-page":"485","article-title":"Infectious keratitis following corneal crosslinking: a systematic review of reported cases: management, visual outcome, and treatment proposed","volume":"31","author":"Abbouda","year":"2016","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib23","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1038\/srep05652","article-title":"Corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis","volume":"4","author":"Chunyu","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.ophtha.2017.10.034_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ophtha.2014.08.026","article-title":"Reduced precision of the Pentacam HR in eyes with mild to moderate keratoconus","volume":"122","author":"Hashemi","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2017.10.034_bib25","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1136\/bjophthalmol-2015-307201","article-title":"Differential precision of corneal Pentacam HR measurements in early and\u00a0advanced keratoconus","volume":"100","author":"Flynn","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib26","first-page":"453","article-title":"Placido disk-based topography versus high-resolution rotating Scheimpflug camera for corneal power measurements in keratoconic and post-LASIK eyes: reliability and agreement","volume":"18","author":"Penna","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.ophtha.2017.10.034_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3928\/1081597X-20160113-01","article-title":"Repeatability of keratometry measurements obtained with three topographers in keratoconic and normal corneas","volume":"32","author":"Guilbert","year":"2016","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2017.10.034_bib28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jcrs.2014.08.043","article-title":"Effect of keratoconus grades on repeatability of keratometry readings: comparison of 5 devices","volume":"41","author":"Hashemi","year":"2015","journal-title":"J\u00a0Cataract Refract Surg"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642017324788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642017324788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T04:32:23Z","timestamp":1570422743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642017324788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0161642017324788"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2017.10.034","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2017.10.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}