{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:10:23Z","timestamp":1785813023469,"version":"3.56.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ophtha.2018.04.035","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T19:53:54Z","timestamp":1529438034000},"page":"1638-1643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Adrenal Suppression in Infants Treated with Topical Ocular Glucocorticoids"],"prefix":"10.1016","volume":"125","author":[{"given":"Regitze","family":"Bangsgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina M.","family":"Main","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f8ril","family":"Boberg-Ans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"la Cour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Lyng","family":"Forman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Haargaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-1460","authenticated-orcid":false,"given":"Jens Folke","family":"Kiilgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2018.04.035_bib1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4158\/EP.9.6.526","article-title":"Cushing\u2019s syndrome caused by unsupervised use of ocular glucocorticoids","volume":"9","author":"Afandi","year":"2003","journal-title":"Endocr Pract"},{"key":"10.1016\/j.ophtha.2018.04.035_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/sj.eye.6701956","article-title":"Exogenous Cushing\u2019s syndrome and topical ocular steroids","volume":"20","author":"Chiang","year":"2006","journal-title":"Eye (Lond)"},{"issue":"2","key":"10.1016\/j.ophtha.2018.04.035_bib3","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-1233","article-title":"Iatrogenic Cushing\u2019s syndrome due to topical ocular glucocorticoid treatment","volume":"139","author":"Fukuhara","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.ophtha.2018.04.035_bib4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1651-2227.2008.01091.x","article-title":"Topical treatment of uveitis resulting in adrenal insufficiency","volume":"98","author":"Kroger","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ophtha.2018.04.035_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.11.2008.1224","article-title":"Iatrogenic Cushing syndrome caused by ocular glucocorticoids in a child","volume":"2009","author":"Messina","year":"2009","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.ophtha.2018.04.035_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0002-9394(00)00501-8","article-title":"Systemic toxicity of topical and periocular corticosteroid therapy in an 11-year-old male with posterior uveitis","volume":"130","author":"Ozerdem","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2018.04.035_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00431-014-2477-1","article-title":"Cushing syndrome after bilateral lensectomy","volume":"174","author":"Scherrer","year":"2015","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ophtha.2018.04.035_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3928\/0191-3913-20010501-13","article-title":"Adrenal suppression and growth retardation from ocular corticosteroids","volume":"38","author":"Steelman","year":"2001","journal-title":"J\u00a0Pediatr Ophthalmol Strabismus"},{"key":"10.1016\/j.ophtha.2018.04.035_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0161-6420(03)00833-9","article-title":"Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma","volume":"111","author":"Goyal","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2018.04.035_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/adc.2010.204859","article-title":"Adrenal suppression following intralesional corticosteroids for periocular haemangiomas","volume":"96","author":"Morkane","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ophtha.2018.04.035_bib11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jcpt.12573","article-title":"Cushing\u2019s syndrome caused by use of synthetic ocular steroid","volume":"42","author":"\u00dcstyol","year":"2017","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.ophtha.2018.04.035_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0002-9394(77)90858-3","article-title":"Fluorinated corticosteroid toxicity in infants","volume":"84","author":"Romano","year":"1977","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2018.04.035_bib13","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.2174\/0929867322666150716113003","article-title":"Adrenal insufficiency caused by locally applied glucocorticoids-myth or fact?","volume":"22","author":"Borresen","year":"2015","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.ophtha.2018.04.035_bib14","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ejim.2013.05.014","article-title":"Why glucocorticoid withdrawal may sometimes be as dangerous as the treatment itself","volume":"24","author":"Dinsen","year":"2013","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ophtha.2018.04.035_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.steroids.2014.07.015","article-title":"Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease","volume":"92","author":"Koper","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.ophtha.2018.04.035_bib16","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1136\/archdischild-2015-308799","article-title":"The diagnosis and treatment of adrenal insufficiency during childhood and adolescence","volume":"101","author":"Park","year":"2016","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ophtha.2018.04.035_bib17","author":"Chrousos"},{"key":"10.1016\/j.ophtha.2018.04.035_bib18","unstructured":"R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2017. Version 3.4.2. Released September 28, 2017. Available at: http:\/\/www.R-project.org. Accessed January 15, 2018."},{"key":"10.1016\/j.ophtha.2018.04.035_bib19","first-page":"101","article-title":"The Infant Aphakia Treatment Study: further on intra- and postoperative complications in the intraocular lens group","volume":"19","author":"Lambert","year":"2015","journal-title":"J\u00a0AAPOS"},{"key":"10.1016\/j.ophtha.2018.04.035_bib20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/bjophthalmol-2015-307287","article-title":"Use of the Delphi process in paediatric cataract management","volume":"100","author":"Serafino","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2018.04.035_bib21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/eye.2012.12","article-title":"Do topical ophthalmic corticosteroids suppress the hypothalamic-pituitary-adrenal axis in post-penetrating keratoplasty patients?","volume":"26","author":"Sandhu","year":"2012","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ophtha.2018.04.035_bib22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1600-0420.2007.00885.x","article-title":"Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye","volume":"85","author":"Sigurdsson","year":"2007","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ophtha.2018.04.035_bib23","doi-asserted-by":"crossref","first-page":"712549","DOI":"10.1186\/1687-9856-2010-712549","article-title":"Duration of suppression of adrenal steroids after glucocorticoid administration","volume":"2010","author":"Fuqua","year":"2010","journal-title":"Int J Pediatr Endocrinol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642018302781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642018302781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:05:40Z","timestamp":1758981940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642018302781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0161642018302781"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2018.04.035","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adrenal Suppression in Infants Treated with Topical Ocular Glucocorticoids","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2018.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}