{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:31:19Z","timestamp":1792787479655,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ophthalmic Research Institute of Australia","id":[{"id":"https:\/\/ror.org\/00n4vb132","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000890","name":"National MS Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sydney Eye Hospital Foundation","id":[{"id":"https:\/\/ror.org\/03eee6m44","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007811","name":"Sydney Medical School Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ophtha.2019.01.016","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T05:41:16Z","timestamp":1548999676000},"page":"801-810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Evidence of M\u00fcller Glial Dysfunction in Patients with Aquaporin-4 Immunoglobulin G\u2013Positive Neuromyelitis Optica Spectrum Disorder"],"prefix":"10.1016","volume":"126","author":[{"given":"Yuyi","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Yiannikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-7743","authenticated-orcid":false,"given":"Clare L.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-0274","authenticated-orcid":false,"given":"Mark","family":"Gillies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Klistorner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2019.01.016_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel","volume":"202","author":"Lennon","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.ophtha.2019.01.016_bib2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ophtha.2018.06.022","article-title":"Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder","volume":"126","author":"Shen","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2019.01.016_bib4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/1352458514567216","article-title":"Neuromyelitis optica and multiple sclerosis: seeing differences through optical coherence tomography","volume":"21","author":"Bennett","year":"2015","journal-title":"Mult Scler"},{"key":"10.1016\/j.ophtha.2019.01.016_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1177\/1352458515593406","article-title":"Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis","volume":"22","author":"Ramanathan","year":"2016","journal-title":"Mult Scler"},{"key":"10.1016\/j.ophtha.2019.01.016_bib6","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1152\/physrev.00011.2013","article-title":"Physiological roles of aquaporin-4 in brain","volume":"93","author":"Nagelhus","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ophtha.2019.01.016_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1474-4422(12)70133-3","article-title":"Aquaporin 4 and neuromyelitis optica","volume":"11","author":"Papadopoulos","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib8","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1073\/pnas.1109980108","article-title":"Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes","volume":"109","author":"Hinson","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ophtha.2019.01.016_bib9","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000311","article-title":"Effects of neuromyelitis optica-IgG at the blood-brain barrier in\u00a0vitro","volume":"4","author":"Takeshita","year":"2017","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.ophtha.2019.01.016_bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/brain\/awy338","article-title":"Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease","volume":"142","author":"You","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.ophtha.2019.01.016_bib11","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000334","article-title":"Microstructural visual system changes in AQP4-antibody-seropositive NMOSD","volume":"4","author":"Oertel","year":"2017","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.ophtha.2019.01.016_bib12","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000347","article-title":"Foveal thinning in neuromyelitis optica: a sign of retinal astrocytopathy?","volume":"4","author":"Yamamura","year":"2017","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.ophtha.2019.01.016_bib13","series-title":"Principles and Practice of Clinical Electrophysiology of Vision","article-title":"Origins of the electroretinogram","author":"Frishman","year":"2006"},{"key":"10.1016\/j.ophtha.2019.01.016_bib14","series-title":"Ryan\u2019s Retinal Imaging and Diagnostics","article-title":"Electrogenesis of the electroretinogram","author":"Frishman","year":"2013"},{"key":"10.1016\/j.ophtha.2019.01.016_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.ophtha.2019.01.016_bib16","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1212\/WNL.0b013e318248dec1","article-title":"Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays","volume":"78","author":"Waters","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.ophtha.2019.01.016_bib17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10633-008-9155-4","article-title":"ISCEV standard for full-field clinical electroretinography (2008 update)","volume":"118","author":"Marmor","year":"2009","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib19","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000427","article-title":"Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS","volume":"5","author":"You","year":"2018","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.ophtha.2019.01.016_bib20","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1167\/iovs.15-19047","article-title":"Progressive loss of retinal ganglion cells and axons in non-optic neuritis eyes in multiple sclerosis: a longitudinal optical coherence tomography study","volume":"57","author":"Graham","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.01.016_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034823","article-title":"The OSCAR-IB consensus criteria for retinal OCT quality assessment","volume":"7","author":"Tewarie","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2019.01.016_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/1352458514538110","article-title":"Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria","volume":"21","author":"Schippling","year":"2015","journal-title":"Mult Scler"},{"key":"10.1016\/j.ophtha.2019.01.016_bib23","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/ene.13404","article-title":"Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations","volume":"24","author":"Klistorner","year":"2017","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib24","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1212\/WNL.0000000000002774","article-title":"The APOSTEL recommendations for reporting quantitative optical coherence tomography studies","volume":"86","author":"Cruz-Herranz","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.ophtha.2019.01.016_bib25","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1007\/s12035-017-0840-8","article-title":"Disruption of de novo serine synthesis in Muller cells induced mitochondrial dysfunction and aggravated oxidative damage","volume":"55","author":"Zhang","year":"2018","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2018.06.016","article-title":"Characterization of canonical Wnt signalling changes after induced disruption of Muller cell in murine retina","volume":"175","author":"Zhu","year":"2018","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ophtha.2019.01.016_bib27","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1167\/iovs.10-7108","article-title":"Application of advanced statistics in ophthalmology","volume":"52","author":"Fan","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.01.016_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1001891904176","article-title":"Dissecting the dark-adapted electroretinogram","volume":"95","author":"Robson","year":"1998","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib29","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1093\/brain\/awx292","article-title":"MOG-antibody neuromyelitis optica spectrum disorder: is it a separate disease?","volume":"140","author":"de Seze","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.ophtha.2019.01.016_bib30","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000062","article-title":"Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?","volume":"2","author":"Zamvil","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"7","key":"10.1016\/j.ophtha.2019.01.016_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17071145","article-title":"Expression and distribution pattern of aquaporin 4, 5 and 11 in retinas of 15 different species","volume":"17","author":"Amann","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ophtha.2019.01.016_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archopht.117.6.821","article-title":"Muller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacular retinoschisis","volume":"117","author":"Gass","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib33","first-page":"1343","article-title":"Subclinical primary retinal pathology in neuromyelitis optica spectrum disorder","volume":"263","author":"Jeong","year":"2016","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.ophtha.2019.01.016_bib34","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuroscience.2004.08.053","article-title":"Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1","volume":"129","author":"Nagelhus","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ophtha.2019.01.016_bib35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/glia.20318","article-title":"Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels","volume":"53","author":"Binder","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.ophtha.2019.01.016_bib36","first-page":"573","article-title":"Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels","volume":"43","author":"Li","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.01.016_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12974-016-0746-9","article-title":"Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G","volume":"13","author":"Felix","year":"2016","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.ophtha.2019.01.016_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.preteyeres.2017.10.006","article-title":"Mechanisms of macular edema: beyond the surface","volume":"63","author":"Daruich","year":"2018","journal-title":"Prog Retin Eye Res"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016164201833166X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016164201833166X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:06:34Z","timestamp":1758981994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016164201833166X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S016164201833166X"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2019.01.016","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence of M\u00fcller Glial Dysfunction in Patients with Aquaporin-4 Immunoglobulin G\u2013Positive Neuromyelitis Optica Spectrum Disorder","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2019.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of OphthalmologyThis is an open access article under the CC BY-NC-ND license (<inter-ref xlink: href=http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/>http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/<\/inter-ref>).","name":"copyright","label":"Copyright"}]}}