{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:38:22Z","timestamp":1794019102943,"version":"4.8.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007811","name":"Sydney Medical School Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ophtha.2019.02.029","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T11:18:51Z","timestamp":1552043931000},"page":"935-945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":253,"title":["Keratoconus Natural Progression"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-3087","authenticated-orcid":false,"given":"Alex C.","family":"Ferdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J.","family":"Rozema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2019.02.029_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00006324-199703000-00025","article-title":"Keratoconus: age of onset and natural history","volume":"74","author":"Jimenez","year":"1997","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9394(14)71636-8","article-title":"Assessment of health-related quality of life after corneal transplantation","volume":"124","author":"Musch","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10384-007-0453-2","article-title":"Longitudinal changes in corneal irregular astigmatism and visual acuity in eyes with keratoconus","volume":"51","author":"Suzuki","year":"2007","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib4","first-page":"2537","article-title":"Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study","volume":"39","author":"Zadnik","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.ICL.0000095230.24618.03","article-title":"Clinical performance and fitting characteristics with a multicurve lens for keratoconus","volume":"30","author":"Lee","year":"2004","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.ophtha.2019.02.029_bib6","first-page":"369","article-title":"Early diagnosis of keratoconus with Orbscan-II anterior system","volume":"22","author":"Li","year":"2002","journal-title":"J\u00a0Huazhong Univ Sci Technol Med Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/ICO.0000000000000833","article-title":"evolution profiles of different corneal parameters in progressive keratoconus","volume":"35","author":"Tellouck","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1167\/iovs.11-8118","article-title":"Progression of keratoconus by longitudinal assessment with corneal topography","volume":"53","author":"Choi","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib9","first-page":"57","article-title":"Keratoconus follow up by elevation topography","volume":"77","author":"Aguirre-Gonzalez","year":"2003","journal-title":"Rev Mex Oftalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.ico.0000178728.57435.df","article-title":"Longitudinal changes in corneal curvature in keratoconus","volume":"25","author":"McMahon","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1167\/iovs.15-18650","article-title":"Quantitative evaluation of the natural progression of keratoconus using three-dimensional optical coherence tomography","volume":"57","author":"Fujimoto","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/ICO.0b013e318030df5a","article-title":"Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in\u00a0vivo confocal microscopy in humans","volume":"26","author":"Mazzotta","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","article-title":"Global consensus on keratoconus and ectatic diseases","volume":"34","author":"Gomes","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib14","series-title":"Cochrane Database of Systematic Reviews [Internet]","article-title":"Corneal collagen cross-linking for treating keratoconus","author":"Sykakis","year":"2015"},{"key":"10.1016\/j.ophtha.2019.02.029_bib15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jtos.2014.05.002","article-title":"Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis","volume":"12","author":"Craig","year":"2014","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ophtha.2019.02.029_bib16","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1038\/srep05652","article-title":"Corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis","volume":"4","author":"Chunyu","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.ophtha.2019.02.029_bib17","article-title":"The role of Scheimpflug imaging derived parameters in the progression of keratoconus: a systematic review and retrospective study","volume":"56","author":"Ramdas","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.ophtha.2019.02.029_bib19","series-title":"Joanna Briggs Institute Reviewers\u2019 Manual","year":"2014"},{"key":"10.1016\/j.ophtha.2019.02.029_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3928\/1081-597X-19970701-16","article-title":"Proper method for calculating average visual acuity","volume":"13","author":"Holladay","year":"1997","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib21","volume":"Vol. 4","author":"Higgins","year":"2011"},{"key":"10.1016\/j.ophtha.2019.02.029_bib22","first-page":"1","article-title":"mice: multivariate imputation by chained equations in R","author":"van Buuren","year":"2010","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.ophtha.2019.02.029_bib23","series-title":"R: A Language and Environment for Statistical Computing","year":"2015"},{"issue":"3","key":"10.1016\/j.ophtha.2019.02.029_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Software"},{"key":"10.1016\/j.ophtha.2019.02.029_bib25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3928\/1081597X-20140401-01","article-title":"Changes of corneal topography indices after CXL in progressive keratoconus assessed by Scheimpflug camera","volume":"30","author":"Kranitz","year":"2014","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib26","article-title":"Clinical results of transepithelial corneal collagen cross-linking in the treatment of keratoconus","volume":"52","author":"Chen","year":"2016","journal-title":"Zhonghua Yan Ke Za Zhi Chin J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3928\/1081597X-20090401-02","article-title":"Contralateral eye study of corneal collagen cross-Linking with riboflavin and UVA irradiation in patients with keratoconus","volume":"25","author":"Coskunseven","year":"2009","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.sjopt.2015.02.005","article-title":"Corneal collagen crosslinking for progressive keratoconus in Saudi Arabia: one-year controlled clinical trial analysis","volume":"29","author":"Khattak","year":"2015","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib29","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4103\/0974-9233.159755","article-title":"Corneal collagen cross-linking in the treatment of progressive keratoconus: a randomized controlled contralateral eye study","volume":"22","author":"Seyedian","year":"2015","journal-title":"Middle East Afr J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/ICO.0b013e31826672e2","article-title":"Effects of corneal cross-linking on contrast sensitivity, visual acuity, and corneal topography in patients with keratoconus","volume":"32","author":"Lamy","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0161-6420(88)33161-1","article-title":"Keratoconus: contact lens or keratoplasty?","volume":"95","author":"Smiddy","year":"1988","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2019.02.029_bib32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3928\/1081597X-20080601-08","article-title":"Measure of keratoconus progression using Orbscan II","volume":"24","author":"Kim","year":"2008","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/cxo.12566","article-title":"Scotopic contrast sensitivity and glare after accelerated corneal cross-linking","volume":"101","author":"Asgari","year":"2018","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.ophtha.2019.02.029_bib34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.clae.2013.11.012","article-title":"Progression of keratoconus in patients wearing pancorneal toric edge rigid gas-permeable contact lenses","volume":"37","author":"Ramdas","year":"2014","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2019.02.029_bib35","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4274\/tjo.90377","article-title":"Results of application of rigid gas permeable contact lenses in patients with keratoconus","volume":"43","author":"Yazar","year":"2013","journal-title":"Turk Oftalmoloiji Derg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1475-1313.2010.00724.x","article-title":"The effect of the YK lens in keratoconus","volume":"30","author":"Kang","year":"2010","journal-title":"Ophthalmic Physiol Opt"},{"key":"10.1016\/j.ophtha.2019.02.029_bib37","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1136\/bjophthalmol-2016-308682","article-title":"The natural history of corneal topographic progression of keratoconus after age 30 years in non-contact lens wearers","volume":"101","author":"Gokul","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib38","first-page":"523","article-title":"Tomographic indices as possible risk factors for progression in pediatric keratoconus","volume":"20","author":"Hamilton","year":"2016","journal-title":"J\u00a0AAPOS"},{"key":"10.1016\/j.ophtha.2019.02.029_bib39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3341\/kjo.2013.27.3.162","article-title":"Topographic progression of keratoconus in the Korean population","volume":"27","author":"Ahn","year":"2013","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib40","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1111\/aos.13296","article-title":"Topographic, tomographic and biomechanical corneal changes during pregnancy in patients with keratoconus: a cohort study","volume":"95","author":"Naderan","year":"2017","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.ophtha.2019.02.029_bib41","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.jcrs.2013.03.017","article-title":"Transepithelial corneal collagen crosslinking for progressive keratoconus in a pediatric age group","volume":"39","author":"Salman","year":"2013","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib42","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jcrs.2008.04.016","article-title":"Two-year interval changes in Orbscan II topography in eyes with keratoconus","volume":"34","author":"Sahin","year":"2008","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib43","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1167\/iovs.10-6856","article-title":"Vector analysis of evolutive corneal astigmatic changes in keratoconus","volume":"52","author":"Pinero","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib44","first-page":"2001","article-title":"Visual outcomes of Orbiflex K lenses in patients with keratoconus","volume":"16","author":"Akmaz","year":"2016","journal-title":"Int Eye Sci"},{"key":"10.1016\/j.ophtha.2019.02.029_bib45","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3928\/1081597X-20120823-01","article-title":"Corneal changes in progressive keratoconus after cross-linking assessed by Scheimpflug camera","volume":"28","author":"Kranitz","year":"2012","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib46","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jcrs.2013.05.022","article-title":"Epithelial-disruption collagen crosslinking for keratoconus: one-year results","volume":"39","author":"Rechichi","year":"2013","journal-title":"J\u00a0Cataract Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib47","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/00003226-200211000-00011","article-title":"Factors associated with the need for penetrating keratoplasty in keratoconus","volume":"21","author":"Sray","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib48","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1001\/archophthalmol.2009.205","article-title":"Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus","volume":"127","author":"Vinciguerra","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib49","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/ceo.12035","article-title":"Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus","volume":"41","author":"Viswanathan","year":"2013","journal-title":"Clin Experiment Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib50","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1136\/bjo.2010.196493","article-title":"A\u00a0randomised, prospective study to investigate the efficacy of riboflavin\/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus","volume":"95","author":"O\u2019Brart","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0161-6420(94)31313-3","article-title":"Prognostic factors for the progression of keratoconus","volume":"101","author":"Tuft","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2019.02.029_bib52","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clae.2007.03.001","article-title":"Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study: methods and findings to date","volume":"30","author":"Wagner","year":"2007","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2019.02.029_bib53","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ajo.2007.11.017","article-title":"Changes in the quality-of-life of people with keratoconus","volume":"4","author":"Kymes","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib54","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ophtha.2013.10.028","article-title":"A\u00a0randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results","volume":"121","author":"Wittig-Silva","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2019.02.029_bib55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clae.2008.07.001","article-title":"30 years of contact lens prescribing for keratoconic patients in Turkey","volume":"32","author":"Bilgin","year":"2009","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.ophtha.2019.02.029_bib56","doi-asserted-by":"crossref","first-page":"38","DOI":"10.17116\/oftalma2015131538-42","article-title":"Long-term efficacy of corneal collagen cross-linking in patients with progressive keratoconus","volume":"131","author":"Bubnova","year":"2015","journal-title":"Vestn Oftalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib57","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5935\/0004-2749.20170022","article-title":"Keratoconus progression is not inhibited by reducing eyelid muscular force with botulinum toxin A treatment: a randomized trial","volume":"80","author":"Renesto","year":"2017","journal-title":"Arq Bras Oftalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib58","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12886-015-0070-7","article-title":"Prospective, randomized, double-blind trial to investigate the efficacy and safety of corneal cross-linking to halt the progression of keratoconus","volume":"15","author":"Lang","year":"2015","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib59","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/ICO.0000000000001513","article-title":"repeated same-day versus single tomography measurements of keratoconic eyes for analysis of disease progression","volume":"37","author":"Wonneberger","year":"2018","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib60","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3928\/1081597X-20180206-03","article-title":"Variation in the best fit sphere radius of curvature as a test to detect keratoconus progression on a Scheimpflug-based corneal tomographer","volume":"34","author":"Gupta","year":"2018","journal-title":"J\u00a0Refract Surg Thorofare"},{"key":"10.1016\/j.ophtha.2019.02.029_bib61","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/ICO.0000000000001629","article-title":"Corneal cross-linking in pediatric patients: evaluating treated and untreated eyes-5-year follow-up results","volume":"37","author":"Or","year":"2018","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2019.02.029_bib62","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ajo.2006.07.026","article-title":"Baseline factors predictive of incident penetrating keratoplasty in keratoconus","volume":"142","author":"Gordon","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib63","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/aos.13095","article-title":"Nationwide reduction in the number of corneal transplantations for keratoconus following the implementation of cross-linking","volume":"94","author":"Godefrooij","year":"2016","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.ophtha.2019.02.029_bib64","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3928\/1081597X-20121115-04","article-title":"Pentacam HR criteria for curvature change in keratoconus and postoperative LASIK ectasia","volume":"28","author":"Epstein","year":"2012","journal-title":"J\u00a0Refract Surg"},{"key":"10.1016\/j.ophtha.2019.02.029_bib65","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ophtha.2014.08.026","article-title":"Reduced precision of the Pentacam HR in eyes with mild to moderate keratoconus","volume":"122","author":"Hashemi","year":"2015","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ophtha.2019.02.029_bib66","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1136\/bjophthalmol-2015-307201","article-title":"Differential precision of corneal Pentacam HR measurements in early and advanced keratoconus","volume":"100","author":"Flynn","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib67","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/0301-4738.116054","article-title":"Epidemiology of keratoconus","volume":"61","author":"Gokhale","year":"2013","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib68","first-page":"38","article-title":"Epidemiology of keratoconus in the Urals","volume":"114","author":"Gorskova","year":"1998","journal-title":"Vestn Oftalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib69","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/opo.12448","article-title":"High prevalence and familial aggregation of keratoconus in an Iranian rural population: a population-based study","volume":"38","author":"Hashemi","year":"2018","journal-title":"Ophthalmic Physiol Opt"},{"key":"10.1016\/j.ophtha.2019.02.029_bib70","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/09286586.2011.560747","article-title":"Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study","volume":"18","author":"Millodot","year":"2011","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib71","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/eye.2000.154","article-title":"Does ethnic origin influence the incidence or severity of keratoconus?","volume":"14","author":"Pearson","year":"2000","journal-title":"Eye"},{"key":"10.1016\/j.ophtha.2019.02.029_bib72","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40662-016-0038-6","article-title":"Assessing progression of keratoconus: novel tomographic determinants","volume":"3","author":"Duncan","year":"2016","journal-title":"Eye Vis"},{"issue":"4","key":"10.1016\/j.ophtha.2019.02.029_bib73","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/bjophthalmol-2017-311651","article-title":"Evaluation of keratoconus progression","volume":"103","author":"Shajari","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajo.2018.08.054","article-title":"Enhanced ectasia detection using corneal tomography and biomechanics","volume":"197","author":"Ferreira-Mendes","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2019.02.029_bib75","first-page":"694542","article-title":"Vision related quality of life in patients with keratoconus","volume":"2014","author":"Kurna","year":"2014","journal-title":"J\u00a0Ophthalmol"},{"issue":"7","key":"10.1016\/j.ophtha.2019.02.029_bib76","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1097\/ICO.0b013e31823cbe85","article-title":"Impact of keratoconus, cross-linking and cross-linking combined with photorefractive keratectomy on self-reported quality of life","volume":"31","author":"Labiris","year":"2012","journal-title":"Cornea"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642018332871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642018332871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:06:44Z","timestamp":1758982004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642018332871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":76,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0161642018332871"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2019.02.029","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keratoconus Natural Progression","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2019.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}