{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:24:16Z","timestamp":1781249056597,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08EY026986"],"award-info":[{"award-number":["K08EY026986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ophtha.2019.03.039","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T11:59:30Z","timestamp":1554379170000},"page":"1090-1094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis"],"prefix":"10.1016","volume":"126","author":[{"given":"Prajna","family":"Lalitha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerami D.","family":"Seitzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Kotecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Hinterwirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo E.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Lebas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malaya K.","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Pinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Lietman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ophtha.2019.03.039_bib1","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1185\/03007990903038269","article-title":"Acute conjunctivitis: truth and misconceptions","volume":"25","author":"O\u2019Brien","year":"2009","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"10.1016\/j.ophtha.2019.03.039_bib2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/sj.eye.6700330","article-title":"Epidemic kerato-conjunctivitis--do outbreaks have to be epidemic?","volume":"17","author":"Cheung","year":"2003","journal-title":"Eye (Lond)"},{"issue":"Pt 4","key":"10.1016\/j.ophtha.2019.03.039_bib3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1099\/jmm.0.051722-0","article-title":"Vittaforma corneae keratitis in southern India: role of a novel duplex PCR","volume":"62","author":"Bharathi","year":"2013","journal-title":"J\u00a0Med Microbiol"},{"issue":"4","key":"10.1016\/j.ophtha.2019.03.039_bib4","first-page":"212","article-title":"[Enteroviruses responsible for acute hemorrhagic conjunctivitis]","volume":"40","author":"Leveque","year":"2010","journal-title":"Med Mal Infect"},{"issue":"10","key":"10.1016\/j.ophtha.2019.03.039_bib5","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1136\/bjophthalmol-2016-309845","article-title":"Clinical and demographic study of microsporidial keratoconjunctivitis in South India: a 3-year study (2013-2015)","volume":"101","author":"Agashe","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ophtha.2019.03.039_bib6","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.ophtha.2018.02.016","article-title":"Determinants of outcomes of adenoviral keratoconjunctivitis","volume":"125","author":"Lee","year":"2018","journal-title":"Ophthalmology"},{"issue":"16","key":"10.1016\/j.ophtha.2019.03.039_bib7","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1001\/jama.2013.280318","article-title":"Conjunctivitis: a systematic review of diagnosis and treatment","volume":"310","author":"Azari","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ophtha.2019.03.039_bib8","series-title":"Guide to Trachoma Control","author":"Dawson","year":"1981"},{"issue":"1","key":"10.1016\/j.ophtha.2019.03.039_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13073-016-0344-6","article-title":"Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens","volume":"8","author":"Doan","year":"2016","journal-title":"Genome Med"},{"issue":"4","key":"10.1016\/j.ophtha.2019.03.039_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/jamaophthalmol.2018.6185","article-title":"Association of ocular inflammation and rubella virus persistence","volume":"137","author":"Gonzales","year":"2018","journal-title":"JAMA Ophthalmol"},{"issue":"2","key":"10.1016\/j.ophtha.2019.03.039_bib11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/ICO.0000000000001790","article-title":"Capnocytophaga keratitis: clinical presentation and use of metagenomic deep sequencing for diagnosis","volume":"38","author":"Seitzman","year":"2019","journal-title":"Cornea"},{"issue":"8","key":"10.1016\/j.ophtha.2019.03.039_bib12","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.ophtha.2017.03.045","article-title":"Metagenomic DNA sequencing for the diagnosis of intraocular infections","volume":"124","author":"Doan","year":"2017","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ophtha.2019.03.039_bib13","doi-asserted-by":"crossref","first-page":"ofy182","DOI":"10.1093\/ofid\/ofy182","article-title":"Mass azithromycin distribution and community microbiome: a cluster-randomized trial","volume":"5","author":"Doan","year":"2018","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"10.1016\/j.ophtha.2019.03.039_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/bjophthalmol-2017-311151","article-title":"Metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas","volume":"102","author":"Gonzales","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ophtha.2019.03.039_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.ophtha.2019.03.039_bib16","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkw199","article-title":"Profiler-a web server for functional interpretation of gene lists (2016 update)","volume":"44","author":"Reimand","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.ophtha.2019.03.039_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.ophtha.2019.03.039_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.ophtha.2019.03.039_bib19","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/archopht.121.7.1045","article-title":"Microsporidial stromal keratitis","volume":"121","author":"Font","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"10.1016\/j.ophtha.2019.03.039_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9394(14)70833-5","article-title":"Microsporidial keratoconjunctivitis in a patient without human immunodeficiency virus infection","volume":"124","author":"Silverstein","year":"1997","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ophtha.2019.03.039_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0002-9394(14)70792-5","article-title":"Ocular and sinus microsporidial infection cured with systemic albendazole","volume":"124","author":"Gritz","year":"1997","journal-title":"Am J Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016164201930452X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016164201930452X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:06:47Z","timestamp":1758982007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016164201930452X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S016164201930452X"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2019.03.039","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2019.03.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}