{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:19:28Z","timestamp":1769829568683,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ophtha.2020.09.021","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T22:49:05Z","timestamp":1600469345000},"page":"754-764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk Factors for Acute Choroidal Ischemia after Intra-arterial Melphalan for Retinoblastoma"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-2716","authenticated-orcid":false,"given":"Christina","family":"Stathopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6055-0221","authenticated-orcid":false,"given":"Bruno","family":"Bartolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-1056","authenticated-orcid":false,"given":"Guillaume","family":"Marie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-5697","authenticated-orcid":false,"given":"Maja","family":"Beck-Popovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-7976","authenticated-orcid":false,"given":"Guillaume","family":"Saliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis L.","family":"Munier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ophtha.2020.09.021_bib1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.3174\/ajnr.A3019","article-title":"Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization","volume":"33","author":"Klufas","year":"2012","journal-title":"AJNR Am J Neuroradiol"},{"issue":"11","key":"10.1016\/j.ophtha.2020.09.021_bib2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/jamaophthalmol.2015.3108","article-title":"Treatment of retinoblastoma in 2015: agreement and disagreement","volume":"133","author":"Abramson","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"8","key":"10.1016\/j.ophtha.2020.09.021_bib3","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.ophtha.2007.12.014","article-title":"A\u00a0phase I\/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results","volume":"115","author":"Abramson","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2020.09.021_bib4","first-page":"289","article-title":"Chemo-thermotherapy was successful in two cases of recurrence of intraocular retinoblastoma after irradiation","volume":"44","author":"Kaneko","year":"1990","journal-title":"Rinsho Ganka (Jpn J Clin Ophthalmol)"},{"issue":"2","key":"10.1016\/j.ophtha.2020.09.021_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10147-004-0392-6","article-title":"The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma","volume":"9","author":"Yamane","year":"2004","journal-title":"Int J Clin Oncol"},{"issue":"4","key":"10.1016\/j.ophtha.2020.09.021_bib6","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1136\/neurintsurg-2011-010019","article-title":"Zygomatico-orbital intra-arterial melphalan infusion for intraocular retinoblastoma","volume":"4","author":"Cooke","year":"2012","journal-title":"J\u00a0Neurointerv Surg"},{"issue":"8","key":"10.1016\/j.ophtha.2020.09.021_bib7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00234-011-0978-4","article-title":"Access to the ophthalmic artery by retrograde approach through the posterior communicating artery for intra-arterial chemotherapy of retinoblastoma","volume":"54","author":"Pham","year":"2012","journal-title":"Neuroradiology"},{"issue":"9","key":"10.1016\/j.ophtha.2020.09.021_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00247-016-3554-6","article-title":"A\u00a0review of the literature for intra-arterial chemotherapy used to treat retinoblastoma","volume":"46","author":"Wyse","year":"2016","journal-title":"Pediatr Radiol"},{"issue":"6","key":"10.1016\/j.ophtha.2020.09.021_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamaophthalmol.2016.0025","article-title":"Delayed cerebral infarction following intra-arterial chemotherapy for retinoblastoma","volume":"134","author":"De la Huerta","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"10.1016\/j.ophtha.2020.09.021_bib10","first-page":"137","article-title":"Globe salvage with intra-arterial topotecan-melphalan chemotherapy in children with a single eye","volume":"68","author":"Leal-Leal","year":"2016","journal-title":"Rev Invest Clin"},{"issue":"3","key":"10.1016\/j.ophtha.2020.09.021_bib11","first-page":"211","article-title":"Intra-arterial chemotherapy for retinoblastoma: 8-year experience from a tertiary referral institute in Thailand","volume":"8","author":"Rojanaporn","year":"2019","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"3","key":"10.1016\/j.ophtha.2020.09.021_bib12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/1591019918755088","article-title":"Improved procedural safety following protocol changes for selective ophthalmic arterial infusion of chemotherapy for treatment of ocular retinoblastoma","volume":"24","author":"Ammanuel","year":"2018","journal-title":"Interv Neuroradiol"},{"issue":"11","key":"10.1016\/j.ophtha.2020.09.021_bib13","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.ophtha.2018.05.013","article-title":"Ophthalmic vascular events after primary unilateral intra-arterial chemotherapy for retinoblastoma in early and recent eras","volume":"125","author":"Dalvin","year":"2018","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ophtha.2020.09.021_bib14","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ophtha.2011.09.040","article-title":"Fluorescein angiographic findings after intra-arterial chemotherapy for retinoblastoma","volume":"119","author":"Bianciotto","year":"2012","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ophtha.2020.09.021_bib15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ophtha.2011.08.045","article-title":"Efficacy and complications of super-selective intra-ophthalmic artery melphalan for the treatment of refractory retinoblastoma","volume":"119","author":"Muen","year":"2012","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.ophtha.2020.09.021_bib16","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1097\/IAE.0000000000002315","article-title":"Ophthalmic vascular events after intra-arterial chemotherapy for retinoblastoma: real-world comparison between primary and secondary treatments","volume":"39","author":"Ancona-Lezama","year":"2019","journal-title":"Retina"},{"issue":"6","key":"10.1016\/j.ophtha.2020.09.021_bib17","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archophthalmol.2011.5","article-title":"Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience","volume":"129","author":"Gobin","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ophtha.2020.09.021_bib18","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/bjophthalmol-2017-310294","article-title":"Reduction of severe visual loss and complications following intra-arterial chemotherapy (IAC) for refractory retinoblastoma","volume":"101","author":"Reddy","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ophtha.2020.09.021_bib19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jamaophthalmol.2013.2065","article-title":"Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings","volume":"131","author":"Tse","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"5","key":"10.1016\/j.ophtha.2020.09.021_bib20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/aos.12990","article-title":"Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells","volume":"94","author":"S\u00fcsskind","year":"2016","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ophtha.2020.09.021_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874364101206010001","article-title":"Intraocular hemorrhage after intra-arterial chemotherapy for retinoblastoma in sickle cell trait","volume":"6","author":"Abramson","year":"2012","journal-title":"Open Ophthalmol J"},{"issue":"12","key":"10.1016\/j.ophtha.2020.09.021_bib22","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1001\/archophthalmol.2012.2284","article-title":"Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery","volume":"130","author":"Francis","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ophtha.2020.09.021_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ohc.2004.11.003","article-title":"Intraocular retinoblastoma: the case for a new group classification","volume":"18","author":"Linn Murphree","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"key":"10.1016\/j.ophtha.2020.09.021_bib24","doi-asserted-by":"crossref","first-page":"100764","DOI":"10.1016\/j.preteyeres.2019.05.005","article-title":"Conservative management of retinoblastoma: challenging orthodoxy without compromising the state of metastatic grace. \u201cAlive, with good vision and no comorbidity","volume":"73","author":"Munier","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"10.1016\/j.ophtha.2020.09.021_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/IAE.0b013e318203c101","article-title":"Occurrence of sectoral choroidal occlusive vasculopathy and retinal arteriolar embolization after superselective ophthalmic artery chemotherapy for advanced intraocular retinoblastoma","volume":"31","author":"Munier","year":"2011","journal-title":"Retina"},{"issue":"9","key":"10.1016\/j.ophtha.2020.09.021_bib26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/bjophthalmol-2013-303267","article-title":"Intra-arterial chemotherapy with melphalan for intraocular retinoblastoma","volume":"97","author":"Bracco","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"10.1016\/j.ophtha.2020.09.021_bib27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1001\/archophthalmol.2011.223","article-title":"Histopathologic observations after intra-arterial chemotherapy for retinoblastoma","volume":"129","author":"Eagle","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"11","key":"10.1016\/j.ophtha.2020.09.021_bib28","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1136\/bjophthalmol-2013-303694","article-title":"Visual outcomes following intraophthalmic artery melphalan for patients with refractory retinoblastoma and age appropriate vision","volume":"97","author":"Tsimpida","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"10.1016\/j.ophtha.2020.09.021_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27086","article-title":"Feasibility and results of an intraarterial chemotherapy program for the conservative treatment of retinoblastoma in Argentina","volume":"65","author":"Funes","year":"2018","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"10.1016\/j.ophtha.2020.09.021_bib30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/aos.13333","article-title":"Outcome of intra-arterial chemotherapy for retinoblastoma and its influencing factors: a retrospective study","volume":"95","author":"Chen","year":"2017","journal-title":"Acta Ophthalmol"},{"issue":"4","key":"10.1016\/j.ophtha.2020.09.021_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1755-3768.2011.02296.x","article-title":"Superselective ophthalmic artery infusion of melphalan for intraocular retinoblastoma: preliminary results from 140 treatments","volume":"91","author":"Venturi","year":"2013","journal-title":"Acta Ophthalmol"},{"issue":"7","key":"10.1016\/j.ophtha.2020.09.021_bib32","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.ophtha.2014.01.026","article-title":"Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma","volume":"121","author":"Shields","year":"2014","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ophtha.2020.09.021_bib33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/pbc.24170","article-title":"Ophthalmic artery chemosurgery for the management of retinoblastoma in eyes with extensive (>50%) retinal detachment","volume":"59","author":"Palioura","year":"2012","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"10.1016\/j.ophtha.2020.09.021_bib34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00234-014-1388-1","article-title":"An alternative technique of the superselective catheterization of the ophthalmic artery for intra-arterial chemotherapy of the retinoblastoma: retrograde approach through the posterior communicating artery to the ophthalmic artery","volume":"56","author":"Saglam","year":"2014","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.ophtha.2020.09.021_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146582","article-title":"Intra-arterial chemotherapy (ophthalmic artery chemosurgery) for group D retinoblastoma","volume":"11","author":"Abramson","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ophtha.2020.09.021_bib36","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1167\/iovs.18-25346","article-title":"Rabbit model of intra-arterial chemotherapy toxicity demonstrates retinopathy and vasculopathy related to drug and dose, not procedure or approach","volume":"60","author":"Daniels","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ophtha.2020.09.021_bib37","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1167\/iovs.12-9466","article-title":"Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis","volume":"53","author":"Steinle","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.ophtha.2020.09.021_bib38","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/archophthalmol.2011.330","article-title":"Real-time ophthalmoscopic findings of superselective intraophthalmic artery chemotherapy in a nonhuman primate model","volume":"129","author":"Wilson","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"10.1016\/j.ophtha.2020.09.021_bib39","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1001\/archophthalmol.2012.180","article-title":"Real-time ophthalmoscopic findings of intraophthalmic artery chemotherapy in retinoblastoma","volume":"130","author":"Fallaha","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"10.1016\/j.ophtha.2020.09.021_bib40","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2011.03.013","article-title":"Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis","volume":"118","author":"Suzuki","year":"2011","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.ophtha.2020.09.021_bib41","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1097\/IAE.0000000000000190","article-title":"Choroidal thickness after intraarterial chemotherapy for retinoblastoma","volume":"34","author":"Maidana","year":"2014","journal-title":"Retina"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642020309040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642020309040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:10:17Z","timestamp":1758982217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642020309040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0161642020309040"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2020.09.021","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Factors for Acute Choroidal Ischemia after Intra-arterial Melphalan for Retinoblastoma","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2020.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}