{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:55:02Z","timestamp":1794243302959,"version":"4.9.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008017","name":"Flinders Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ophtha.2021.04.016","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T11:02:58Z","timestamp":1618916578000},"page":"1549-1560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Childhood and Early Onset Glaucoma Classification and Genetic Profile in a Large Australasian Disease Registry"],"prefix":"10.1016","volume":"128","author":[{"given":"Lachlan S.W.","family":"Knight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Ruddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa A.","family":"Taranath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Gole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Y.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faren","family":"Willett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"D\u2019Mellow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-0925","authenticated-orcid":false,"given":"James","family":"Breen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayub","family":"Qassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-6011","authenticated-orcid":false,"given":"Sean","family":"Mullany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Staffieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Kearns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Mackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen M.","family":"Siggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-6577","authenticated-orcid":false,"given":"Emmanuelle","family":"Souzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"R1","key":"10.1016\/j.ophtha.2021.04.016_bib1","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1093\/hmg\/ddx184","article-title":"Genetics of glaucoma","volume":"26","author":"Wiggs","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib2","series-title":"World Glaucoma Association (WGA) Consensus Series 9 - Childhood Glaucoma","first-page":"3","article-title":"Section 1: Definition, classification, differential diagnosis","author":"Beck","year":"2013"},{"key":"10.1016\/j.ophtha.2021.04.016_bib3","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/IJG.0000000000000887","article-title":"Visual disability among juvenile open-angle glaucoma patients","volume":"27","author":"Gupta","year":"2018","journal-title":"J\u00a0Glaucoma"},{"issue":"R1","key":"10.1016\/j.ophtha.2021.04.016_bib4","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1093\/hmg\/ddx205","article-title":"Primary congenital and developmental glaucomas","volume":"26","author":"Lewis","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1001\/jamaophthalmol.2018.5646","article-title":"Prevalence of FOXC1 variants in individuals with a suspected diagnosis of primary congenital glaucoma","volume":"137","author":"Siggs","year":"2019","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1442-9071.2011.02742.x","article-title":"Australian and New Zealand Registry of Advanced Glaucoma: methodology and recruitment","volume":"40","author":"Souzeau","year":"2012","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/ICU.0000000000000516","article-title":"New classification system for pediatric glaucoma: implications for clinical care and a research registry","volume":"29","author":"Thau","year":"2018","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib8","series-title":"World Glaucoma Association (WGA) Consensus Series 9 - Childhood Glaucoma","first-page":"155","article-title":"Section 7: Glaucoma associated with non-acquired ocular anomalies","author":"Banitt","year":"2013"},{"key":"10.1016\/j.ophtha.2021.04.016_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.survophthal.2006.02.006","article-title":"A\u00a0review of anterior segment dysgeneses","volume":"51","author":"Idrees","year":"2006","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib10","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.ophtha.2021.04.016_bib11","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1001\/jamaophthalmol.2015.0980","article-title":"Occurrence of CYP1B1 mutations in juvenile open-angle glaucoma with advanced visual field loss","volume":"133","author":"Souzeau","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ajo.2014.09.044","article-title":"Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma","volume":"159","author":"Awadalla","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib13","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.ophtha.2019.12.024","article-title":"Biallelic CPAMD8 variants are a frequent cause of childhood and juvenile open-angle glaucoma","volume":"127","author":"Siggs","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2021.04.016_bib14","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/ejhg.2017.147","article-title":"Glaucoma spectrum and age-related prevalence of individuals with FOXC1 and PITX2 variants","volume":"25","author":"Souzeau","year":"2017","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib15","first-page":"261","article-title":"PAX6 molecular analysis and genotype-phenotype correlations in families with aniridia from Australasia and Southeast Asia","volume":"24","author":"Souzeau","year":"2018","journal-title":"Mol Vis"},{"key":"10.1016\/j.ophtha.2021.04.016_bib16","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/jamaophthalmol.2014.946","article-title":"Mutation in TMEM98 in a large white kindred with autosomal dominant nanophthalmos linked to 17p12-q12","volume":"132","author":"Awadalla","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.ophtha.2012.11.029","article-title":"Higher prevalence of myocilin mutations in advanced glaucoma in comparison with less advanced disease in an Australasian disease registry","volume":"120","author":"Souzeau","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2021.04.016_bib18","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1172\/JCI85830","article-title":"Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity","volume":"126","author":"Souma","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ophtha.2021.04.016_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.61.12.6","article-title":"SVEP1 as a genetic modifier of TEK-related primary congenital glaucoma","volume":"61","author":"Young","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2021.04.016_bib20","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1172\/JCI95545","article-title":"Angiopoietin-1 is required for Schlemm\u2019s canal development in mice and humans","volume":"127","author":"Thomson","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ophtha.2021.04.016_bib23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/IJG.0000000000001259","article-title":"Prevalence and clinical characteristics of childhood glaucoma at a tertiary care children\u2019s hospital","volume":"28","author":"Bouhenni","year":"2019","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2021.04.016_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0301-4738.179716","article-title":"A\u00a0retrospective survey of childhood glaucoma prevalence according to Childhood Glaucoma Research Network classification","volume":"64","author":"Hoguet","year":"2016","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib25","first-page":"674","article-title":"Childhood glaucoma profile in Dakahelia, Egypt: a retrospective study","volume":"11","author":"Mokbel","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4103\/ijo.IJO_786_18","article-title":"Profile of childhood glaucoma at a tertiary center in South India","volume":"67","author":"Senthil","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/IJG.0000000000001712","article-title":"Childhood glaucoma profile in a Brazilian tertiary care center using Childhood Glaucoma Research Network Classification","volume":"30","author":"Lopes","year":"2021","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2021.04.016_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ogla.2019.12.007","article-title":"International Study of Childhood Glaucoma \u2013 Childhood Glaucoma Research Network Study Group. International study of childhood glaucoma","volume":"3","author":"Papadopoulos","year":"2020","journal-title":"Ophthalmol Glaucoma"},{"key":"10.1016\/j.ophtha.2021.04.016_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1442-9071.2004.00750.x","article-title":"Primary infantile glaucoma in an Australian population","volume":"32","author":"MacKinnon","year":"2004","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib30","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1167\/iovs.06-1350","article-title":"BIG Eye Study Investigators. The British infantile and childhood glaucoma (BIG) eye study","volume":"48","author":"Papadopoulos","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2021.04.016_bib31","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2021.04.016_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/bjophthalmol-2019-314660","article-title":"Classifying juvenile onset primary open angle glaucoma using cluster analysis","volume":"104","author":"Birla","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib33","first-page":"1229","article-title":"Analysis of CYP1B1 in pediatric and adult glaucoma and other ocular phenotypes","volume":"22","author":"Reis","year":"2016","journal-title":"Mol Vis"},{"key":"10.1016\/j.ophtha.2021.04.016_bib34","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41436-020-0854-x","article-title":"Revealing hidden genetic diagnoses in the ocular anterior segment disorders","volume":"22","author":"Ma","year":"2020","journal-title":"Genet Med"},{"key":"10.1016\/j.ophtha.2021.04.016_bib35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1399-0004.2007.00864.x","article-title":"Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma","volume":"72","author":"Dimasi","year":"2007","journal-title":"Clin Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib36","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ajo.2012.09.012","article-title":"CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States","volume":"155","author":"Lim","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/hmg\/9.3.367","article-title":"Multiple CYP1B1 mutations and incomplete penetrance in an inbred population segregating primary congenital glaucoma suggest frequent de novo events and a dominant modifier locus","volume":"9","author":"Bejjani","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib38","first-page":"75","article-title":"Sex bias in primary congenital glaucoma patients with and without CYP1B1 mutations","volume":"4","author":"Suri","year":"2009","journal-title":"J\u00a0Ophthalmic Vis Res"},{"key":"10.1016\/j.ophtha.2021.04.016_bib39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/bjo.87.3.302","article-title":"Phenotype of cytochrome P4501B1 gene (CYP1B1) mutations in Japanese patients with primary congenital glaucoma","volume":"87","author":"Ohtake","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045077","article-title":"Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis","volume":"7","author":"Mookherjee","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2021.04.016_bib41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0002-9394(00)00536-5","article-title":"Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma","volume":"130","author":"Shimizu","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2021.04.016_bib42","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1086\/302098","article-title":"Prevalence of mutations in TIGR\/myocilin in patients with adult and juvenile primary open-angle glaucoma","volume":"63","author":"Wiggs","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib43","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ophtha.2021.04.016_bib44","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1167\/iovs.10-5309","article-title":"Expanding the spectrum of FOXC1 and PITX2 mutations and copy number changes in patients with anterior segment malformations","volume":"52","author":"D\u2019haene","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2021.04.016_bib45","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/ejhg.2012.80","article-title":"PITX2 and FOXC1 spectrum of mutations in ocular syndromes","volume":"20","author":"Reis","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119272","article-title":"Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability","volume":"10","author":"Medina-Trillo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ophtha.2021.04.016_bib47","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00439-020-02164-0","article-title":"CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix","volume":"139","author":"Bonet-Fern\u00e1ndez","year":"2020","journal-title":"Hum Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib48","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00439-018-1878-z","article-title":"Congenital glaucoma and CYP1B1: an old story revisited","volume":"138","author":"Alsaif","year":"2019","journal-title":"Hum Genet"},{"key":"10.1016\/j.ophtha.2021.04.016_bib49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3928\/01913913-20180905-01","article-title":"Systemic associations of childhood glaucoma: a review","volume":"55","author":"Midha","year":"2018","journal-title":"J\u00a0Pediatr Ophthalmol Strabismus"},{"key":"10.1016\/j.ophtha.2021.04.016_bib50","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa1213507","article-title":"Sturge\u2013Weber syndrome and port-wine stains caused by somatic mutation in GNAQ","volume":"368","author":"Shirley","year":"2013","journal-title":"N\u00a0Engl J Med"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642021002888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642021002888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:11:21Z","timestamp":1758982281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642021002888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0161642021002888"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2021.04.016","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Childhood and Early Onset Glaucoma Classification and Genetic Profile in a Large Australasian Disease Registry","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2021.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}]}}