{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:08:26Z","timestamp":1788973706542,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","aaojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ophtha.2022.03.024","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T11:36:04Z","timestamp":1648467364000},"page":"865-879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Bevacizumab in High-Risk Corneal Transplantation"],"prefix":"10.1016","volume":"129","author":[{"given":"Thomas H.","family":"Dohlman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-0440","authenticated-orcid":false,"given":"Matthew","family":"McSoley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Amparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Carreno-Galeano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-883X","authenticated-orcid":false,"given":"Mohammad","family":"Dastjerdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan Bir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-6366","authenticated-orcid":false,"given":"Giulia","family":"Coco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Zazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasanain","family":"Shikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujwala","family":"Saboo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Sippel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ciralsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-5943","authenticated-orcid":false,"given":"Sonia H.","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-5984","authenticated-orcid":false,"given":"Matheus","family":"Sticca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-7032","authenticated-orcid":false,"given":"Tais H.","family":"Wakamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somasheila","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedram","family":"Hamrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ula","family":"Jurkunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Ciolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-9531","authenticated-orcid":false,"given":"Jose A.P.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-6758","authenticated-orcid":false,"given":"Jia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2022.03.024_bib1","series-title":"Blindness and Vision Impairment","year":"2021"},{"key":"10.1016\/j.ophtha.2022.03.024_bib2","series-title":"2019 Eye Banking Statistical Report","year":"2019"},{"key":"10.1016\/j.ophtha.2022.03.024_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/bjophthalmol-2020-316705","article-title":"Corneal graft failure: an update","volume":"105","author":"Alio","year":"2021","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib4","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1001\/archopht.1992.01080220054021","article-title":"The Collaborative Corneal Transplantation Studies (CCTS). Effectiveness of histocompatibility matching in high-risk corneal transplantation. The Collaborative Corneal Transplantation Studies Research Group","volume":"110","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.tp.0000185197.37824.35","article-title":"How effective is penetrating corneal transplantation? Factors influencing long-term outcome in multivariate analysis","volume":"81","author":"Williams","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.ophtha.2022.03.024_bib6","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.ajo.2005.07.024","article-title":"The impact of corneal allograft rejection on the long-term outcome of corneal transplantation","volume":"140","author":"Coster","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib7","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0161-6420(94)31138-9","article-title":"Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Collaborative Corneal Transplantation Studies Research Group","volume":"101","author":"Maguire","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2022.03.024_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10792-007-9099-9","article-title":"Graft failure IV. Immunologic mechanisms of corneal transplant rejection","volume":"28","author":"Chong","year":"2008","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib9","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1167\/iovs.15-17551","article-title":"Graft site microenvironment determines dendritic cell trafficking through the CCR7-CCL19\/21 axis","volume":"57","author":"Hua","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib10","first-page":"2485","article-title":"Loss and restoration of immune privilege in eyes with corneal neovascularization","volume":"37","author":"Dana","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.ophtha.2022.03.024_bib12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ophtha.2022.03.024_bib13","first-page":"18","article-title":"Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization","volume":"9","author":"Amano","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib14","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib15","first-page":"2326","article-title":"Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization","volume":"15","author":"Dratviman-Storobinsky","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.ophtha.2022.03.024_bib16","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0161-6420(03)00463-9","article-title":"Long-term graft survival after penetrating keratoplasty","volume":"110","author":"Thompson","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2022.03.024_bib17","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.03-1380","article-title":"Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib18","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1167\/iovs.09-3745","article-title":"Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival","volume":"51","author":"Dastjerdi","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archophthalmol.2009.18","article-title":"Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study","volume":"127","author":"Dastjerdi","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib20","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.ajo.2012.06.007","article-title":"Short-term topical bevacizumab in the treatment of stable corneal neovascularization","volume":"154","author":"Cheng","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib21","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/ICO.0b013e31821379aa","article-title":"Combined use of subconjunctival and intracorneal bevacizumab injection for corneal neovascularization","volume":"30","author":"Yeung","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2022.03.024_bib22","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/ICO.0b013e31817786ad","article-title":"Subconjunctival bevacizumab for corneal neovascularization","volume":"27","author":"Doctor","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2022.03.024_bib23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/ICO.0b013e318159019f","article-title":"Subconjunctival bevacizumab injection for corneal neovascularization","volume":"27","author":"Bahar","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2022.03.024_bib24","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/ICO.0b013e3181ba0ae2","article-title":"Corneal graft surgery combined with subconjunctival bevacizumab (avastin)","volume":"29","author":"Symes","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2022.03.024_bib25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00417-014-2851-8","article-title":"Three-year corneal graft survival rate in high-risk cases treated with subconjunctival and topical bevacizumab","volume":"253","author":"Dekaris","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib26","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s00417-009-1170-y","article-title":"Avastin use in high risk corneal transplantation","volume":"247","author":"Vassileva","year":"2009","journal-title":"G\u00a0Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib27","doi-asserted-by":"crossref","first-page":"NP48","DOI":"10.1177\/1120672120939504","article-title":"Long-term topical bevacizumab for prevention of corneal graft rejections","volume":"31","author":"Kuo","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10792-014-9938-4","article-title":"Subconjunctival and\/or intrastromal bevacizumab injections as preconditioning therapy to promote corneal graft survival","volume":"35","author":"Fasciani","year":"2015","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib29","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/ICO.0b013e31823f8f7a","article-title":"Angioregressive pretreatment of mature corneal blood vessels before keratoplasty: fine-needle vessel coagulation combined with anti-VEGFs","volume":"31","author":"Koenig","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2022.03.024_bib30","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/ICO.0b013e318180e50f","article-title":"Bevacizumab (Avastin) and argon laser to treat neovascularization in corneal transplant surgery","volume":"27","author":"Gerten","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.ophtha.2022.03.024_bib31","doi-asserted-by":"crossref","first-page":"e452","DOI":"10.1097\/TXD.0000000000000894","article-title":"Risk of corneal graft rejection after high-risk keratoplasty following fine-needle vessel coagulation of corneal neovascularization combined with bevacizumab: a pilot study","volume":"5","author":"Hos","year":"2019","journal-title":"Transplant Direct"},{"key":"10.1016\/j.ophtha.2022.03.024_bib32","first-page":"1256","article-title":"Efficacy of sub-conjunctival and topical bevacizumab in high-risk corneal transplant survival","volume":"63","author":"Bhatti","year":"2013","journal-title":"J\u00a0Pak Med Assoc"},{"key":"10.1016\/j.ophtha.2022.03.024_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.12669\/pjms.292.3089","article-title":"Efficacy of topical bevacizumab in high-risk corneal transplant survival","volume":"29","author":"Bhatti","year":"2013","journal-title":"Pak J Med Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib34","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1167\/iovs.11-7871","article-title":"Corneal penetration of topical and subconjunctival bevacizumab","volume":"52","author":"Dastjerdi","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/019262339902700507","article-title":"Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration","volume":"27","author":"Mordenti","year":"1999","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.ophtha.2022.03.024_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40942-016-0026-y","article-title":"Fusion proteins for treatment of retinal diseases: aflibercept, ziv-aflibercept, and conbercept","volume":"2","author":"de Oliveira Dias","year":"2016","journal-title":"Int J Retina Vitreous"},{"key":"10.1016\/j.ophtha.2022.03.024_bib37","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1167\/iovs.07-1418","article-title":"Vascular endothelial growth factor mediates corneal nerve repair","volume":"49","author":"Yu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib38","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1167\/iovs.08-2805","article-title":"Bevacizumab application delays epithelial healing in rabbit cornea","volume":"50","author":"Kim","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib39","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.ophtha.2008.02.013","article-title":"The effect of topical bevacizumab on corneal neovascularization","volume":"115","author":"Kim","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2022.03.024_bib40","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1167\/iovs.16-20926","article-title":"Subconjunctival bevacizumab injection impairs corneal innervations and epithelial wound healing in mice","volume":"58","author":"Dong","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2022.03.024_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3928\/15428877-20100215-07","article-title":"Corneal melt while using topical bevacizumab eye drops","author":"Galor","year":"2010","journal-title":"Ophthalmic Surg Lasers Imaging"}],"updated-by":[{"DOI":"10.1016\/j.ophtha.2022.08.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000}}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642022002378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642022002378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T07:06:30Z","timestamp":1675062390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642022002378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0161642022002378"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2022.03.024","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bevacizumab in High-Risk Corneal Transplantation","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2022.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}