{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:05:50Z","timestamp":1779278750942,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ophtha.2022.07.031","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T11:03:55Z","timestamp":1659524635000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ophthalmologic Involvement in Adults with Histiocytic Disorders"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-1367","authenticated-orcid":false,"given":"Samantha A.","family":"Banks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-5630","authenticated-orcid":false,"given":"M. Tariq","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-3495","authenticated-orcid":false,"given":"Ronald S.","family":"Go","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jithma P.","family":"Abeykoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-9153","authenticated-orcid":false,"given":"Aldo A.","family":"Acosta-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-3730","authenticated-orcid":false,"given":"Antonious Z.","family":"Hazim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-5177","authenticated-orcid":false,"given":"Gaurav","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-8266","authenticated-orcid":false,"given":"Jason R.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6755","authenticated-orcid":false,"given":"Matthew J.","family":"Koster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay H.","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline J.","family":"Davidge-Pitts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-440X","authenticated-orcid":false,"given":"Aishwarya","family":"Ravindran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-5403","authenticated-orcid":false,"given":"Julio C.","family":"Sartori Valinotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-5953","authenticated-orcid":false,"given":"N. Nora","family":"Bennani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithun V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Rech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Garrity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8141-2394","authenticated-orcid":false,"given":"W. Oliver","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2022.07.031_bib1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.6004\/jnccn.2021.0053","article-title":"Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology","volume":"19","author":"Go","year":"2021","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1016\/j.ophtha.2022.07.031_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jpeds.2020.10.056","article-title":"Langerhans cell histiocytosis of the orbit: spectrum of clinical and imaging findings","volume":"230","author":"Lakatos","year":"2021","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ophtha.2022.07.031_bib3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1148\/radiol.10090320","article-title":"Cerebral, facial, and orbital involvement in Erdheim-Chester disease: CT and MR imaging findings","volume":"255","author":"Drier","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.ophtha.2022.07.031_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ajo.2018.01.037","article-title":"Ophthalmic findings of Rosai-Dorfman disease","volume":"188","author":"Choi","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib5","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.mayocp.2019.02.023","article-title":"The Mayo Clinic Histiocytosis Working Group consensus statement for the diagnosis and evaluation of adult patients with histiocytic neoplasms: Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease","volume":"94","author":"Goyal","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ophtha.2022.07.031_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/CPJ.0000000000000422","article-title":"Neuroradiologic manifestations of Erdheim-Chester disease","volume":"8","author":"Parks","year":"2018","journal-title":"Neurol Clin Pract"},{"key":"10.1016\/j.ophtha.2022.07.031_bib6","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1212\/WNL.0000000000006873","article-title":"Optical coherence tomography is highly sensitive in detecting prior optic neuritis","volume":"92","author":"Xu","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.ophtha.2022.07.031_bib7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1001\/jamaoncol.2017.0041","article-title":"Clinical and radiologic responses to cladribine for the treatment of Erdheim-Chester disease","volume":"3","author":"Goyal","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib8","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1182\/blood-2010-04-279083","article-title":"Recurrent BRAF mutations in Langerhans cell histiocytosis","volume":"116","author":"Badalian-Very","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ophtha.2022.07.031_bib9","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1182\/blood.2019003507","article-title":"Erdheim-Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era","volume":"135","author":"Goyal","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.ophtha.2022.07.031_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/PAS.0000000000001617","article-title":"Rosai-Dorfman disease displays a unique monocyte-macrophage phenotype characterized by expression of OCT2","volume":"45","author":"Ravindran","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.survophthal.2012.09.004","article-title":"Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature","volume":"58","author":"Herwig","year":"2013","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.5301\/ejo.5000244","article-title":"Langerhans cell histiocytosis of the orbit","volume":"23","author":"Kiratli","year":"2013","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib13","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4103\/ijo.IJO_1375_19","article-title":"Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit","volume":"68","author":"Koka","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib14","first-page":"1589","article-title":"Solitary Langerhans histiocytosis of the orbit: case report and review of the literature","volume":"58","author":"\u015eovrea","year":"2017","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib15","doi-asserted-by":"crossref","first-page":"234","DOI":"10.25259\/SNI_140_2019","article-title":"Langerhans cell histiocytosis of the orbit and frontal sinus of the adult woman: a first case report in Poland","volume":"10","author":"Kostyra","year":"2019","journal-title":"Surg Neurol Int"},{"key":"10.1016\/j.ophtha.2022.07.031_bib16","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1097\/IOP.0000000000000555","article-title":"Langerhans cell histiocytosis presenting as a nodulo-ulcerative eyelid lesion","volume":"33","author":"Lo","year":"2017","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"10.1016\/j.ophtha.2022.07.031_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000502946","article-title":"A\u00a0case of multi-system Langerhans Cell Histiocytosis with local invasion of the orbital apex","volume":"10","author":"Yamada","year":"2019","journal-title":"Case Rep Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.surneu.2004.03.017","article-title":"Solitary Langerhans-cell histiocytosis of the clivus and sphenoid sinus with parasellar and petrous extensions: case report and a review of literature","volume":"62","author":"Krishna","year":"2004","journal-title":"Surg Neurol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib20","first-page":"238","article-title":"Ophthalmic manifestations of Rosai-Dorfman disease in five patients","volume":"32","author":"Masoomian","year":"2020","journal-title":"J\u00a0Curr Ophthalmol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8722-1-7","article-title":"Rosai Dorfman disease of the orbit","volume":"1","author":"Vemuganti","year":"2008","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib22","first-page":"S251","article-title":"Radiotherapy is effective in symptomatic Langerhans Cell Histiocytosis (LCH): long-term results of a multicenter study in 63 patients","volume":"57","author":"Seegenschmiedt","year":"2003","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1748-717X-8-233","article-title":"Radiotherapy in Langerhans Cell Histiocytosis-a rare indication in a rare disease","volume":"8","author":"Kriz","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ophtha.2022.07.031_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.radonc.2006.07.034","article-title":"Palliative treatment of Erdheim\u2013Chester disease with radiotherapy: a rare cancer network study","volume":"80","author":"Miller","year":"2006","journal-title":"Radiother Oncol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642022005905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642022005905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:13:01Z","timestamp":1758982381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642022005905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0161642022005905"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2022.07.031","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ophthalmologic Involvement in Adults with Histiocytic Disorders","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2022.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}