{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:07:25Z","timestamp":1778900845190,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ophtha.2023.02.018","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T02:03:56Z","timestamp":1676858636000},"page":"756-763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes"],"prefix":"10.1016","volume":"130","author":[{"given":"Inas F.","family":"Aboobakar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler G.","family":"Kinzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-2737","authenticated-orcid":false,"given":"Baojian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-3496","authenticated-orcid":false,"given":"Louis R.","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-2941","authenticated-orcid":false,"given":"Ayub","family":"Qassim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-0137","authenticated-orcid":false,"given":"Antonia","family":"Kolovos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie E.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-8702","authenticated-orcid":false,"given":"Jessica N.","family":"Cooke Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-3278","authenticated-orcid":false,"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Rand","family":"Allingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Brilliant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald L.","family":"Budenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica N.","family":"Cooke Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Fingert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Gaasterland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Gaasterland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Lichter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syoko","family":"Moroi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Realini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia E.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ritch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel S.","family":"Schuman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuldev","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J.","family":"Sit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Vollrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gadi","family":"Wollstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald J.","family":"Zack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ophtha.2023.02.018_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/ceo.14035","article-title":"The genetics of glaucoma: disease associations, personalised risk assessment and therapeutic opportunities\u2014a review","volume":"50","author":"Aboobakar","year":"2022","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41433-019-0632-7","article-title":"Clinical implications of recent advances in primary open-angle glaucoma genetics","volume":"34","author":"Choquet","year":"2020","journal-title":"Eye (Lond)"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib4","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1002\/cphg.95","article-title":"Genetic risk scores","volume":"104","author":"Igo","year":"2019","journal-title":"Curr Protoc Hum Genet"},{"issue":"10","key":"10.1016\/j.ophtha.2023.02.018_bib5","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/jamaophthalmol.2019.3109","article-title":"Association of a primary open-angle glaucoma genetic risk score with earlier age at diagnosis","volume":"137","author":"Fan","year":"2019","journal-title":"JAMA Ophthalmol"},{"issue":"11","key":"10.1016\/j.ophtha.2023.02.018_bib6","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.3390\/ijms18112302","article-title":"A\u00a0multi-locus genetic risk score for primary open-angle glaucoma (POAG) variants is associated with POAG risk in a Mediterranean population: inverse correlations with plasma vitamin C and E concentrations","volume":"18","author":"Zanon-Moreno","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"Chrysostomou","year":"2013","journal-title":"Curr Opin Pharmacol"},{"issue":"4","key":"10.1016\/j.ophtha.2023.02.018_bib8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3892\/ijmm.2016.2714","article-title":"Oxidative stress in the trabecular meshwork (review)","volume":"38","author":"Zhao","year":"2016","journal-title":"Int J Mol Med"},{"issue":"2","key":"10.1016\/j.ophtha.2023.02.018_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.3482","article-title":"Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma","volume":"48","author":"Bailey","year":"2016","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.ophtha.2023.02.018_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41588-019-0556-y","article-title":"Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression","volume":"52","author":"Craig","year":"2020","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.ophtha.2023.02.018_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/nu11030504","article-title":"Cytoplasmic and mitochondrial NADPH-coupled redox systems in the regulation of aging","volume":"11","author":"Bradshaw","year":"2019","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.ophtha.2023.02.018_bib12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/IJG.0b013e31824d4fd8","article-title":"The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables","volume":"22","author":"Wiggs","year":"2013","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.ophtha.2023.02.018_bib13","series-title":"Clinical Decisions in Glaucoma","author":"Hodapp","year":"1993"},{"issue":"2","key":"10.1016\/j.ophtha.2023.02.018_bib14","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ophtha.2013.09.012","article-title":"Association of CAV1\/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss","volume":"121","author":"Loomis","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jamaophthalmol.2022.4688","article-title":"Association of high polygenic risk with visual field worsening despite treatment in early primary open-angle glaucoma","volume":"141","author":"Siggs","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"database issue","key":"10.1016\/j.ophtha.2023.02.018_bib16","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"6509","key":"10.1016\/j.ophtha.2023.02.018_bib17","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/107327481001700108","article-title":"The false discovery rate: a key concept in large-scale genetic studies","volume":"17","author":"Chen","year":"2010","journal-title":"Cancer Control"},{"issue":"R1","key":"10.1016\/j.ophtha.2023.02.018_bib19","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1093\/hmg\/ddv259","article-title":"Non-coding genetic variants in human disease","volume":"24","author":"Zhang","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.ophtha.2023.02.018_bib20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41588-018-0126-8","article-title":"Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma","volume":"50","author":"Khawaja","year":"2018","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.ophtha.2023.02.018_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/ICU.0b013e32834ff23e","article-title":"Current understanding of conventional outflow dysfunction in glaucoma","volume":"23","author":"Stamer","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"issue":"12","key":"10.1016\/j.ophtha.2023.02.018_bib22","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1167\/iovs.10-5410","article-title":"Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress","volume":"51","author":"Lin","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ophtha.2023.02.018_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","article-title":"Mitochondrial optic neuropathies\u2014disease mechanisms and therapeutic strategies","volume":"30","author":"Yu-Wai-Man","year":"2011","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"10.1016\/j.ophtha.2023.02.018_bib24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/ceo.13818","article-title":"Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomized clinical trial","volume":"48","author":"Hui","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.ophtha.2023.02.018_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamaophthalmol.2021.4576","article-title":"Nicotinamide and pyruvate for neuroenhancement in open-angle glaucoma: a phase 2 randomized clinical trial","volume":"140","author":"De Moraes","year":"2022","journal-title":"JAMA Ophthalmol"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016164202300129X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016164202300129X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:13:34Z","timestamp":1758982414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016164202300129X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S016164202300129X"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2023.02.018","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2023.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}