{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:51:05Z","timestamp":1794336665986,"version":"4.9.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 EY031883"],"award-info":[{"award-number":["R21 EY031883"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY031331"],"award-info":[{"award-number":["R01 EY031331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY010572"],"award-info":[{"award-number":["P30 EY010572"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"NEI","doi-asserted-by":"publisher","award":["R01 EY019474"],"award-info":[{"award-number":["R01 EY019474"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"RPB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ophtha.2024.06.006","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T11:24:41Z","timestamp":1718018681000},"page":"1290-1296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Use of an Artificial Intelligence-Generated Vascular Severity Score Improved Plus Disease Diagnosis in Retinopathy of Prematurity"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-1909","authenticated-orcid":false,"given":"Aaron S.","family":"Coyner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Ostmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5655-0760","authenticated-orcid":false,"given":"Florin","family":"Grigorian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-438X","authenticated-orcid":false,"given":"Baker","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-0852","authenticated-orcid":false,"given":"Sarah H.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-7734","authenticated-orcid":false,"given":"Pukhraj","family":"Rishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-4174","authenticated-orcid":false,"given":"Aaron M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3535-4808","authenticated-orcid":false,"given":"Amit R.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5744-0539","authenticated-orcid":false,"given":"Swati","family":"Agarwal-Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7007-6938","authenticated-orcid":false,"given":"Jonathan","family":"Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. V. Paul","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-7636","authenticated-orcid":false,"given":"Michael F.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashree","family":"Kalpathy-Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Binenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-9475","authenticated-orcid":false,"given":"J. Peter","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ophtha.2024.06.006_bib1","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ophtha.2021.05.031","article-title":"International Classification of Retinopathy of Prematurity, Third Edition","volume":"128","author":"Chiang","year":"2021","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ophtha.2024.06.006_bib2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-053924","article-title":"Retinopathy of prematurity: a global perspective and recent developments","volume":"150","author":"Sabri","year":"2022","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.ophtha.2024.06.006_bib3","article-title":"A\u00a0review on the incidence and related risk factors of retinopathy of prematurity across various countries","volume":"14","author":"Nair","year":"2022","journal-title":"Cureus"},{"issue":"Suppl 1","key":"10.1016\/j.ophtha.2024.06.006_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.ophtha.2024.06.006_bib5","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.survophthal.2018.04.002","article-title":"Retinopathy of prematurity: a review of risk factors and their clinical significance","volume":"63","author":"Kim","year":"2018","journal-title":"Surv Ophthalmol"},{"issue":"5","key":"10.1016\/j.ophtha.2024.06.006_bib34","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jamaophthalmol.2024.0612","article-title":"Access to pediatric eye care by practitioner type, geographic distribution, and US population demographics","volume":"142","author":"Siegler","year":"2024","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2024.06.006_bib6","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial","volume":"102","author":"Good","year":"2004","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"10","key":"10.1016\/j.ophtha.2024.06.006_bib7","first-page":"1408","article-title":"Multicenter trial of cryotherapy for retinopathy of prematurity. One-year outcome\u2014structure and function","volume":"108","year":"1990","journal-title":"Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthal"},{"issue":"12","key":"10.1016\/j.ophtha.2024.06.006_bib8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.oret.2022.05.024","article-title":"Variability in plus disease diagnosis using single and serial images","volume":"6","author":"Cole","year":"2022","journal-title":"Ophthalmol Retina"},{"issue":"11","key":"10.1016\/j.ophtha.2024.06.006_bib9","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.ophtha.2016.07.020","article-title":"Plus disease in retinopathy of prematurity: improving diagnosis by ranking disease severity and using quantitative image analysis","volume":"123","author":"Kalpathy-Cramer","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2024.06.006_bib10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ajo.2016.12.025","article-title":"Plus disease in retinopathy of prematurity: diagnostic trends in 2016 versus 2007","volume":"176","author":"Moleta","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ophtha.2024.06.006_bib11","first-page":"352","article-title":"Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity","volume":"12","author":"Wallace","year":"2008","journal-title":"J\u00a0AAPOS"},{"issue":"11","key":"10.1016\/j.ophtha.2024.06.006_bib12","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/j.ophtha.2016.07.026","article-title":"Plus disease in retinopathy of prematurity: a continuous spectrum of vascular abnormality as a basis of diagnostic variability","volume":"123","author":"Campbell","year":"2016","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ophtha.2024.06.006_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jamaophthalmol.2024.0045","article-title":"Multinational external validation of autonomous retinopathy of prematurity screening","volume":"142","author":"Coyner","year":"2024","journal-title":"JAMA Ophthalmol"},{"issue":"9","key":"10.1016\/j.ophtha.2024.06.006_bib14","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/s41591-018-0107-6","article-title":"Clinically applicable deep learning for diagnosis and referral in retinal disease","volume":"24","author":"De Fauw","year":"2018","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ophtha.2024.06.006_bib15","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1001\/jamaophthalmol.2018.1934","article-title":"Automated diagnosis of plus disease in retinopathy of prematurity using deep convolutional neural networks","volume":"136","author":"Brown","year":"2018","journal-title":"JAMA Ophthalmol"},{"issue":"7","key":"10.1016\/j.ophtha.2024.06.006_bib16","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ophtha.2020.10.025","article-title":"Evaluation of a deep learning-derived quantitative retinopathy of prematurity severity scale","volume":"128","author":"Campbell","year":"2021","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ophtha.2024.06.006_bib17","first-page":"160","article-title":"Evaluation of artificial intelligence-based telemedicine screening for retinopathy of prematurity","volume":"24","author":"Greenwald","year":"2020","journal-title":"J\u00a0AAPOS"},{"issue":"8","key":"10.1016\/j.ophtha.2024.06.006_bib18","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.ophtha.2020.01.052","article-title":"Aggressive posterior retinopathy of prematurity: clinical and quantitative Imaging features in a large North American cohort","volume":"127","author":"Bellsmith","year":"2020","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ophtha.2024.06.006_bib19","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jamaophthalmol.2019.2433","article-title":"Monitoring disease progression with a quantitative severity scale for retinopathy of prematurity using deep learning","volume":"137","author":"Taylor","year":"2019","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"10.1016\/j.ophtha.2024.06.006_bib20","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-016618","article-title":"Applications of artificial intelligence for retinopathy of prematurity screening","volume":"147","author":"Campbell","year":"2021","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.ophtha.2024.06.006_bib21","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-051772","article-title":"Single-examination risk prediction of severe retinopathy of prematurity","volume":"148","author":"Coyner","year":"2021","journal-title":"Pediatrics"},{"issue":"8","key":"10.1016\/j.ophtha.2024.06.006_bib22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/jamaophthalmol.2022.2135","article-title":"External validation of a retinopathy of prematurity screening model using artificial intelligence in 3 low- and middle-income populations","volume":"140","author":"Coyner","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"10.1016\/j.ophtha.2024.06.006_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2022.100165","article-title":"Evaluation of an artificial intelligence system for retinopathy of prematurity screening in Nepal and Mongolia","volume":"2","author":"Cole","year":"2022","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.ophtha.2024.06.006_bib24","first-page":"1902","article-title":"Development and evaluation of reference standards for image-based telemedicine diagnosis and clinical research studies in ophthalmology","author":"Ryan","year":"2014","journal-title":"AMIA Annu Symp Proc"},{"issue":"7","key":"10.1016\/j.ophtha.2024.06.006_bib25","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/j.ophtha.2022.02.008","article-title":"Artificial intelligence for retinopathy of prematurity: validation of a vascular severity scale against international expert diagnosis","volume":"129","author":"Campbell","year":"2022","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ophtha.2024.06.006_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ophtha.2021.12.017","article-title":"DeepLensNet: deep learning automated diagnosis and quantitative classification of cataract type and severity","volume":"129","author":"Keenan","year":"2022","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ophtha.2024.06.006_bib27","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1001\/jamaophthalmol.2020.1376","article-title":"Characterization of drusen and hyperreflective foci as biomarkers for disease progression in age-related macular degeneration using artificial intelligence in optical coherence tomography","volume":"138","author":"Waldstein","year":"2020","journal-title":"JAMA Ophthalmol"},{"issue":"22","key":"10.1016\/j.ophtha.2024.06.006_bib28","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2016.17216","article-title":"Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs","volume":"316","author":"Gulshan","year":"2016","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.ophtha.2024.06.006_bib29","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1097\/IAE.0000000000003884","article-title":"Artificial intelligence\u2019s role in differentiating the origin for subretinal bleeding in pathologic myopia","volume":"43","author":"Crincoli","year":"2023","journal-title":"Retina"},{"issue":"5","key":"10.1016\/j.ophtha.2024.06.006_bib30","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/jamaophthalmol.2018.0649","article-title":"Diagnostic accuracy of ophthalmoscopy vs telemedicine in examinations for retinopathy of prematurity","volume":"136","author":"Biten","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ophtha.2024.06.006_bib31","article-title":"P-score: a reference-image-based clinical grading scale for vascular change in retinopathy of prematurity","volume":"23","author":"Binenbaum","year":"2024","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2024.06.006_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3368\/aoj.63.1.92","article-title":"Socioeconomics of retinopathy of prematurity care in the United States","volume":"63","author":"Braverman","year":"2013","journal-title":"Am Orthopt J"},{"issue":"4","key":"10.1016\/j.ophtha.2024.06.006_bib33","first-page":"227.e1","article-title":"Socioeconomics of retinopathy of prematurity screening and treatment in the United States","volume":"25","author":"Bhatia","year":"2021","journal-title":"J\u00a0AAPOS"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642024003397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642024003397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T01:37:42Z","timestamp":1764121062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642024003397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0161642024003397"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2024.06.006","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of an Artificial Intelligence-Generated Vascular Severity Score Improved Plus Disease Diagnosis in Retinopathy of Prematurity","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2024.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}