{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T00:52:41Z","timestamp":1794185561735,"version":"4.8.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","aaojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ophtha.2024.07.014","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T19:53:39Z","timestamp":1721159619000},"page":"14-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Oral Antioxidant and Lutein\/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-1772","authenticated-orcid":false,"given":"Tiarn\u00e1n D.L.","family":"Keenan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-4042","authenticated-orcid":false,"given":"Elvira","family":"Agr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-745X","authenticated-orcid":false,"given":"Pearse A.","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitha","family":"Domalpally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0999-9802","authenticated-orcid":false,"given":"Emily Y.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib1","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib2","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study","volume":"9","year":"2021","journal-title":"Lancet Glob Health"},{"issue":"1","key":"10.1016\/j.ophtha.2024.07.014_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.ophtha.2024.07.014_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ophtha.2011.09.027","article-title":"Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis","volume":"119","author":"Rudnicka","year":"2012","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.ophtha.2024.07.014_bib5","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.ophtha.2018.05.028","article-title":"Progression of geographic atrophy in age-related macular degeneration: AREDS2 Report Number 16","volume":"125","author":"Keenan","year":"2018","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ophtha.2024.07.014_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ophtha.2017.08.038","article-title":"The progression of geographic atrophy secondary to age-related macular degeneration","volume":"125","author":"Fleckenstein","year":"2018","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ophtha.2024.07.014_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100306","article-title":"Geographic atrophy in age-related macular degeneration: a tale of two stages","volume":"3","author":"Keenan","year":"2023","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.ophtha.2024.07.014_bib8","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.oret.2022.12.007","article-title":"Characteristics and spatial distribution of structural features in age-related macular degeneration: a MACUSTAR Study Report","volume":"7","author":"Sassmannshausen","year":"2023","journal-title":"Ophthalmol Retina"},{"issue":"4","key":"10.1016\/j.ophtha.2024.07.014_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of Atrophy Report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2024.07.014_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.oret.2022.08.018","article-title":"Deep learning to predict geographic atrophy area and growth rate from multimodal imaging","volume":"7","author":"Anegondi","year":"2023","journal-title":"Ophthalmol Retina"},{"issue":"9","key":"10.1016\/j.ophtha.2024.07.014_bib10","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1167\/iovs.17-22339","article-title":"Report from the NEI\/FDA Endpoints Workshop on Age-Related Macular Degeneration and Inherited Retinal Diseases","volume":"58","author":"Csaky","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ophtha.2024.07.014_bib12","author":"Apellis Pharmaceuticals"},{"key":"10.1016\/j.ophtha.2024.07.014_bib13","author":"Bio"},{"issue":"10411","key":"10.1016\/j.ophtha.2024.07.014_bib14","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S0140-6736(23)01520-9","article-title":"Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials","volume":"402","author":"Heier","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ophtha.2019.07.011","article-title":"Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial","volume":"127","author":"Liao","year":"2020","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ophtha.2024.07.014_bib16","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.ophtha.2021.02.025","article-title":"Characterizing new-onset exudation in the randomized phase 2 FILLY Trial of Complement Inhibitor Pegcetacoplan for Geographic Atrophy","volume":"128","author":"Wykoff","year":"2021","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ophtha.2024.07.014_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2021.100057","article-title":"Local complement inhibition for geographic atrophy in age-related macular degeneration: prospects, challenges, and unanswered questions","volume":"1","author":"Keenan","year":"2021","journal-title":"Ophthalmol Sci"},{"issue":"4","key":"10.1016\/j.ophtha.2024.07.014_bib18","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ophtha.2020.08.027","article-title":"C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2\/3 trial","volume":"128","author":"Jaffe","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2024.07.014_bib19","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(23)01583-0","article-title":"Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial","volume":"402","author":"Khanani","year":"2023","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ophtha.2024.07.014_bib20","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/jamaophthalmol.2021.1407","article-title":"Enlargement of geographic atrophy from first diagnosis to end of life","volume":"139","author":"Colijn","year":"2021","journal-title":"JAMA Ophthalmol"},{"issue":"5","key":"10.1016\/j.ophtha.2024.07.014_bib21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/bjophthalmol-2020-317636","article-title":"Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration","volume":"106","author":"Shen","year":"2022","journal-title":"Br J Ophthalmol"},{"issue":"13","key":"10.1016\/j.ophtha.2024.07.014_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.62.13.28","article-title":"Local progression kinetics of geographic atrophy depends upon the border location","volume":"62","author":"Shen","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.ophtha.2024.07.014_bib23","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1167\/iovs.18-26533","article-title":"Foveal sparing in central retinal dystrophies","volume":"60","author":"Bax","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ophtha.2024.07.014_bib24","first-page":"2","article-title":"Topographic variation of the growth rate of geographic atrophy in nonexudative age-related macular degeneration: a systematic review and meta-analysis","volume":"61","author":"Shen","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.ophtha.2024.07.014_bib25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.oret.2020.11.003","article-title":"Relationship of topographic distribution of geographic atrophy to visual acuity in nonexudative age-related macular degeneration","volume":"5","author":"Shen","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.ophtha.2024.07.014_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ajo.2017.03.031","article-title":"Geographic atrophy and foveal-sparing changes related to visual acuity in patients with dry age-related macular degeneration over time","volume":"179","author":"Sayegh","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2024.07.014_bib27","author":"Agron"},{"issue":"5","key":"10.1016\/j.ophtha.2024.07.014_bib28","first-page":"278","article-title":"Percentage of foveal vs total macular geographic atrophy as a predictor of visual acuity in age-related macular degeneration","volume":"3","author":"Bagheri","year":"2019","journal-title":"J\u00a0Vitreoretin Dis"},{"issue":"4","key":"10.1016\/j.ophtha.2024.07.014_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000445217","article-title":"Modeling visual acuity in geographic atrophy secondary to age-related macular degeneration","volume":"235","author":"Schmitz-Valckenberg","year":"2016","journal-title":"Ophthalmologica"},{"issue":"9","key":"10.1016\/j.ophtha.2024.07.014_bib30","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1001\/archophthalmol.2009.198","article-title":"Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26","volume":"127","author":"Lindblad","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"10.1016\/j.ophtha.2024.07.014_bib31","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A\u00a0randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8","volume":"119","year":"2001","journal-title":"Arch Ophthalmol"},{"issue":"19","key":"10.1016\/j.ophtha.2024.07.014_bib32","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1001\/jama.2013.4997","article-title":"Lutein\u00a0+ zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial","volume":"309","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaophthalmol.2013.7376","article-title":"Secondary analyses of the effects of lutein\/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3","volume":"132","author":"Chew","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"10.1016\/j.ophtha.2024.07.014_bib34","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ophtha.2007.08.003","article-title":"Vitamin usage patterns in the prevention of advanced age-related macular degeneration","volume":"115","author":"Charkoudian","year":"2008","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ophtha.2024.07.014_bib35","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/bjophthalmol-2017-310939","article-title":"Cost-effectiveness of age-related macular degeneration study supplements in the UK: combined trial and real-world outcomes data","volume":"102","author":"Lee","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ophtha.2024.07.014_bib36","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1016\/j.ophtha.2019.09.024","article-title":"Age-Related Macular Degeneration Preferred Practice Pattern(R)","volume":"127","author":"Flaxel","year":"2020","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ophtha.2024.07.014_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-2456(99)00031-8","article-title":"The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1","volume":"20","year":"1999","journal-title":"Control Clin Trials"},{"issue":"11","key":"10.1016\/j.ophtha.2024.07.014_bib38","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.ophtha.2012.05.027","article-title":"The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)","volume":"119","author":"Chew","year":"2012","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ophtha.2024.07.014_bib39","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1167\/iovs.13-11804","article-title":"Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2)","volume":"54","author":"Danis","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ophtha.2024.07.014_bib40","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0002-9394(01)01218-1","article-title":"The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6","volume":"132","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ophtha.2024.07.014_bib42","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.oret.2022.03.022","article-title":"Adherence to a Mediterranean diet and geographic atrophy enlargement rate: Age-Related Eye Disease Study 2 Report 29","volume":"6","author":"Agron","year":"2022","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.ophtha.2024.07.014_bib43","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ophtha.2022.11.026","article-title":"Reticular pseudodrusen status, ARMS2\/HTRA1 genotype, and geographic atrophy enlargement: Age-Related Eye Disease Study 2 Report 32","volume":"130","author":"Agron","year":"2023","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.ophtha.2024.07.014_bib44","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1080\/03610929408831436","article-title":"General class of covariance structures for two or more repeated factors in longitudinal data analysis","volume":"23","author":"Galecki","year":"1994","journal-title":"Commun Stat Theory Methods"},{"key":"10.1016\/j.ophtha.2024.07.014_bib45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2288-3-26","article-title":"Design, analysis and presentation of factorial randomised controlled trials","volume":"3","author":"Montgomery","year":"2003","journal-title":"BMC Med Res Methodol"},{"issue":"19","key":"10.1016\/j.ophtha.2024.07.014_bib46","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1001\/jama.289.19.2545","article-title":"Analysis and reporting of factorial trials: a systematic review","volume":"289","author":"McAlister","year":"2003","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib47","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/nu9020120","article-title":"Lutein and zeaxanthin-food sources, bioavailability and dietary variety in age-related macular degeneration protection","volume":"9","author":"Eisenhauer","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ophtha.2024.07.014_bib48","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1001\/jamaophthalmol.2013.572","article-title":"Square root transformation of geographic atrophy area measurements to eliminate dependence of growth rates on baseline lesion measurements: a reanalysis of age-related eye disease study report no. 26","volume":"131","author":"Feuer","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"10.1016\/j.ophtha.2024.07.014_bib49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ophtha.2010.08.018","article-title":"Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography","volume":"118","author":"Yehoshua","year":"2011","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ophtha.2024.07.014_bib50","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/IAE.0000000000002206","article-title":"Prognostic value of shape-descriptive factors for the progression of geographic atrophy secondary to age-related macular degeneration","volume":"39","author":"Pfau","year":"2019","journal-title":"Retina"},{"issue":"6","key":"10.1016\/j.ophtha.2024.07.014_bib51","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1167\/tvst.7.6.40","article-title":"The rate of progression of geographic atrophy decreases with increasing baseline lesion size even after the square root transformation","volume":"7","author":"Mones","year":"2018","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"10.1016\/j.ophtha.2024.07.014_bib52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12874-021-01356-0","article-title":"Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation","volume":"21","author":"Behning","year":"2021","journal-title":"BMC Med Res Methodol"},{"issue":"8","key":"10.1016\/j.ophtha.2024.07.014_bib53","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ophtha.2020.02.009","article-title":"A\u00a0deep learning model for segmentation of geographic atrophy to study its long-term natural history","volume":"127","author":"Liefers","year":"2020","journal-title":"Ophthalmology"},{"issue":"5 Suppl","key":"10.1016\/j.ophtha.2024.07.014_bib54","first-page":"786","article-title":"Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2024.07.014_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-031-27681-1_3","article-title":"Macular pigment carotenoids and bisretinoid A2E","volume":"1415","author":"Arunkumar","year":"2023","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"10.1016\/j.ophtha.2024.07.014_bib56","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/nutrit\/nuac076","article-title":"Potential roles of dietary zeaxanthin and lutein in macular health and function","volume":"81","author":"Li","year":"2023","journal-title":"Nutr Rev"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100274","article-title":"Biologically guided optimization of test target location for rod-mediated dark adaptation in age-related macular degeneration: Alabama Study on Early Age-related Macular Degeneration 2 Baseline","volume":"3","author":"Owsley","year":"2023","journal-title":"Ophthalmol Sci"},{"issue":"3","key":"10.1016\/j.ophtha.2024.07.014_bib58","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.65.3.4","article-title":"Age-related macular degeneration, a mathematically tractable disease","volume":"65","author":"Curcio","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.62.2.26","article-title":"Topographic distribution and progression of soft drusen volume in age-related macular degeneration implicate neurobiology of fovea","volume":"62","author":"Pollreisz","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.ophtha.2024.07.014_bib60","first-page":"1761","article-title":"Measuring geographic atrophy in advanced age-related macular degeneration","volume":"40","author":"Sunness","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib61","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017111","article-title":"Clinical characteristics and current therapies for inherited retinal degenerations","volume":"5","author":"Sahel","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/APO.0000000000000605","article-title":"The impact of systemic medications on retinal function","volume":"12","author":"Somisetty","year":"2023","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"10.1016\/j.ophtha.2024.07.014_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101914","article-title":"Linking biomarkers of oxidative stress and disease with flavonoid consumption: from experimental models to humans","volume":"42","author":"Oteiza","year":"2021","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.ophtha.2024.07.014_bib64","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3945\/an.116.013177","article-title":"The Age-Related Eye Disease 2 Study: micronutrients in the treatment of macular degeneration","volume":"8","author":"Gorusupudi","year":"2017","journal-title":"Adv Nutr"},{"issue":"10","key":"10.1016\/j.ophtha.2024.07.014_bib65","first-page":"600","article-title":"Foveal-sparing scotomas in advanced dry age-related macular degeneration","volume":"102","author":"Sunness","year":"2008","journal-title":"J\u00a0Vis Impair Blind"},{"issue":"7","key":"10.1016\/j.ophtha.2024.07.014_bib66","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/jamaophthalmol.2022.1640","article-title":"Long-term outcomes of adding lutein\/zeaxanthin and omega-3 fatty acids to the AREDS supplements on age-related macular degeneration progression: AREDS2 Report 28","volume":"140","author":"Chew","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"2","key":"10.1016\/j.ophtha.2024.07.014_bib67","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1167\/tvst.9.2.57","article-title":"Artificial intelligence algorithms for analysis of geographic atrophy: a review and evaluation","volume":"9","author":"Arslan","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"8","key":"10.1016\/j.ophtha.2024.07.014_bib69","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1001\/jamaophthalmol.2019.1318","article-title":"Assessment of novel genome-wide significant gene loci and lesion growth in geographic atrophy secondary to age-related macular degeneration","volume":"137","author":"Grassmann","year":"2019","journal-title":"JAMA Ophthalmol"},{"issue":"11","key":"10.1016\/j.ophtha.2024.07.014_bib70","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.ophtha.2016.06.025","article-title":"Evaluation of geographic atrophy from color photographs and fundus autofluorescence images: Age-Related Eye Disease Study 2 Report Number 11","volume":"123","author":"Domalpally","year":"2016","journal-title":"Ophthalmology"},{"issue":"395","key":"10.1016\/j.ophtha.2024.07.014_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf1443","article-title":"Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration","volume":"9","author":"Yaspan","year":"2017","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.ophtha.2024.07.014_bib72","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1097\/IAE.0b013e3182509778","article-title":"Comparison of color fundus photographs and fundus autofluorescence images in measuring geographic atrophy area","volume":"32","author":"Khanifar","year":"2012","journal-title":"Retina"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642024004251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642024004251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T02:43:47Z","timestamp":1734489827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642024004251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0161642024004251"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2024.07.014","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral Antioxidant and Lutein\/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2024.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier on behalf of the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}