{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:49:16Z","timestamp":1785440956546,"version":"3.56.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aaojournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ophtha.2025.03.031","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T18:39:38Z","timestamp":1743964778000},"page":"911-920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of Sickle Cell Retinopathy in Pediatric and Adolescent Patients Enrolled in a Large Cohort Study"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6377-9586","authenticated-orcid":false,"given":"Barbara D.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford M.","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Hoehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ophtha.2025.03.031_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0002-9394(71)90429-6","article-title":"Classification and pathogenesis of proliferative sickle retinopathy","volume":"71","author":"Goldberg","year":"1971","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2022.10233","article-title":"Sickle cell disease: a review","volume":"328","author":"Kavanagh","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.ophtha.2025.03.031_bib4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/bjh.15617","article-title":"Elevated fetal haemoglobin levels are associated with decreased incidence of retinopathy in adults with sickle cell disease","volume":"183","author":"Mian","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/bjh.12238","article-title":"Protection from sickle cell retinopathy is associated with elevated HbF levels and hydroxycarbamide use in children","volume":"161","author":"Estepp","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM199807023390102","article-title":"Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography","volume":"339","author":"Adams","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ophtha.2025.03.031_bib7","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.ophtha.2019.02.023","article-title":"Prevalence and onset of pediatric sickle cell retinopathy","volume":"126","author":"Li","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ophtha.2025.03.031_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaapos.2010.11.014","article-title":"Pediatric sickle cell retinopathy: correlation with clinical factors","volume":"15","author":"Rosenberg","year":"2011","journal-title":"J AAPOS"},{"issue":"10","key":"10.1016\/j.ophtha.2025.03.031_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010790.pub2","article-title":"Laser therapy for retinopathy in sickle cell disease","volume":"2015","author":"Myint","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"9","key":"10.1016\/j.ophtha.2025.03.031_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27228","article-title":"Sickle Cell Clinical Research and Intervention Program (SCCRIP): a lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood","volume":"65","author":"Hankins","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ophtha.2025.03.031_bib12","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B","article-title":"Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group","volume":"17","author":"D\u2019Agostino","year":"1998","journal-title":"Stat Med"},{"key":"10.1016\/j.ophtha.2025.03.031_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"Rosenbaum","year":"1983","journal-title":"Biometrika"},{"key":"10.1016\/j.ophtha.2025.03.031_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/pan\/mpl013","article-title":"Matching as nonparametric preprocessing for reducing model dependence in parametric causal inference","volume":"15","author":"Ho","year":"2007","journal-title":"Political Analysis"},{"key":"10.1016\/j.ophtha.2025.03.031_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3129\/i08-003","article-title":"A screening strategy for the detection of sickle cell retinopathy in pediatric patients","volume":"43","author":"Gill","year":"2008","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib16","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1182\/bloodadvances.2022009147","article-title":"Natural history and rate of progression of retinopathy in adult patients with sickle cell disease: an 11-year follow-up study","volume":"7","author":"Brandsen","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.ophtha.2025.03.031_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40942-022-00419-8","article-title":"Risk factors associated with sickle cell retinopathy: findings from the Cooperative Study of Sickle Cell Disease","volume":"8","author":"Nawaiseh","year":"2022","journal-title":"Int J Retina Vitreous"},{"key":"10.1016\/j.ophtha.2025.03.031_bib18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/bjo.72.10.727","article-title":"Sickle cell retinopathy in Jamaican children: further observations from a cohort study","volume":"72","author":"Talbot","year":"1988","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib19","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/11206721231199273","article-title":"Visual outcome of treating proliferative sickle cell retinopathy in 108 eyes","volume":"34","author":"Okonkwo","year":"2024","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archopht.1971.00990050430006","article-title":"Natural history of untreated proliferative sickle retinopathy","volume":"85","author":"Goldberg","year":"1971","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ophtha.2025.03.031_bib21","first-page":"1138","article-title":"Action on sickle cell retinopathy: the time is now","volume":"36","author":"Dinah","year":"2022","journal-title":"Eye (Basingstoke)"}],"container-title":["Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642025002167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161642025002167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T15:23:20Z","timestamp":1752852200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161642025002167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0161642025002167"],"URL":"https:\/\/doi.org\/10.1016\/j.ophtha.2025.03.031","relation":{},"ISSN":["0161-6420"],"issn-type":[{"value":"0161-6420","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of Sickle Cell Retinopathy in Pediatric and Adolescent Patients Enrolled in a Large Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ophtha.2025.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}