{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:26:25Z","timestamp":1790720785788,"version":"4.1.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Optometry"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.optom.2016.09.003","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T21:00:14Z","timestamp":1482958814000},"page":"205-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired Forms"],"prefix":"10.1016","volume":"10","author":[{"given":"Yasmine L.","family":"Pilz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry J.","family":"Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.optom.2016.09.003_bib0475","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/ceo.12086","article-title":"Mitochondrial optic neuropathies: our travels from bench to bedside and back again","volume":"41","author":"Sadun","year":"2013","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0480","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/WNO.0b013e3182901969","article-title":"Drug-related mitochondrial optic neuropathies","volume":"33","author":"Wang","year":"2013","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0485","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol Rev"},{"issue":"April","key":"10.1016\/j.optom.2016.09.003_bib0490","first-page":"4235","article-title":"Mitochondrial optic neuropathies","volume":"72","author":"Sadun","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"January","key":"10.1016\/j.optom.2016.09.003_bib0495","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.optom.2016.09.003_bib0500","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/archopht.120.6.791","article-title":"The distribution of mitochondrial activity in relation to optic nerve structure","volume":"120","author":"Bristow","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0505","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1167\/iovs.12-10452","article-title":"Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathy","volume":"53","author":"Pan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.optom.2016.09.003_bib0510","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s11910-012-0260-0","article-title":"Disorders of the optic nerve in mitochondrial cytopathies: new ideas on pathogenesis and therapeutic targets","volume":"12","author":"Sitarz","year":"2012","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.optom.2016.09.003_bib0515","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/aos.12515","article-title":"Toxic optic neuropathies: an updated review","volume":"93","author":"Grzybowski","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0520","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/bjo.71.3.192","article-title":"Use of contrast sensitivity measurement in the detection of subclinical ethambutol toxic optic neuropathy","volume":"71","author":"Salmon","year":"1987","journal-title":"Br J Ophthalmol"},{"issue":"December","key":"10.1016\/j.optom.2016.09.003_bib0525","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s00417-015-3150-8","article-title":"Longitudinal analysis of retinal nerve fibre layer and ganglion cell-inner plexiform layer thickness in ethambutol-induced optic neuropathy","volume":"253","author":"Han","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0530","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ophtha.2009.07.026","article-title":"Natural history of Leber's hereditary optic neuropathy: longitudinal analysis of the retinal nerve fibre layer by optical coherence tomography","volume":"117","author":"Barboni","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.optom.2016.09.003_bib0535","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/WNO.0b013e31829b4265","article-title":"Linezolid-associated optic neuropathy in a patient with drug-resistant tuberculosis","volume":"33","author":"Han","year":"2013","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0540","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/IJG.0b013e31804d23aa","article-title":"Stratus OCT in dominant optic atrophy: features differentiating it from glaucoma","volume":"16","author":"Kim","year":"2007","journal-title":"J Glaucoma"},{"key":"10.1016\/j.optom.2016.09.003_bib0545","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1755-3768.2008.01469.x","article-title":"Axonal loss occurs early in dominant optic atrophy","volume":"88","author":"Milea","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0550","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1167\/iovs.07-0024","article-title":"Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations","volume":"48","author":"Ito","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.optom.2016.09.003_bib0555","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ophtha.2004.06.034","article-title":"Retinal nerve fibre layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy","volume":"112","author":"Barboni","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.optom.2016.09.003_bib0560","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0002-9394(14)78298-4","article-title":"The visual-evoked potential in tobacco-alcohol and nutritional amblyopia","volume":"95","author":"Kupersmith","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0565","first-page":"28","article-title":"Arthroprosthetic cobaltism: identification of the at-risk patient","volume":"52","author":"Tower","year":"2010","journal-title":"Alaska Med"},{"key":"10.1016\/j.optom.2016.09.003_bib0570","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00402-011-1268-7","article-title":"Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication","volume":"131","author":"Pazzaglia","year":"2011","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.optom.2016.09.003_bib0575","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0140-6736(09)60490-6","article-title":"Loss of sight and sound. Could it be the hip?","volume":"373","author":"Rizzetti","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.optom.2016.09.003_bib0580","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/346066","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England","volume":"72","author":"Yu-Wai-Man","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0585","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajo.2005.11.007","article-title":"Influence of mutation type on clinical expression of Leber hereditary optic neuropathy","volume":"141","author":"Spruijt","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0590","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","article-title":"Mitochondrial optic neuropathies \u2013 disease mechanisms and therapeutic strategies","volume":"30","author":"Yu-Wai-Man","year":"2011","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.optom.2016.09.003_bib0595","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/jmg.2007.054270","article-title":"Inherited mitochondrial optic neuropathies","volume":"46","author":"Yu-Wai-Man","year":"2009","journal-title":"J Med Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0600","unstructured":"Sherman J, Nath S. Retina Revealed: Case #38 Leber's Hereditary Optic Neuropathy. Review of Optometry. Available at: http:\/\/retinarevealed.com\/case-38-lebers-hereditary-optic-neuropathy.aspx. Accessed 25.08.16."},{"key":"10.1016\/j.optom.2016.09.003_bib0605","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0161-6420(96)30665-9","article-title":"Ophthalmologic findings in Leber hereditary optic neuropathy, with special reference to mtDNA mutations","volume":"103","author":"Nikoskelainen","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.optom.2016.09.003_bib0610","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1002\/mus.880181417","article-title":"Mitochondrial DNA diseases: genotype and phenotype in Leber's hereditary optic neuropathy","volume":"3","author":"Harding","year":"1995","journal-title":"Muscle Nerve Suppl"},{"key":"10.1016\/j.optom.2016.09.003_bib0615","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/bjo.83.5.577","article-title":"Smoking as an aetiological factor in a pedigree with Leber's hereditary optic neuropathy","volume":"83","author":"Tsao","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0620","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0002-9394(03)00099-0","article-title":"Extensive investigation of a large Brazilian pedigree of 11778\/haplogroup J Leber hereditary optic neuropathy","volume":"136","author":"Sadun","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"September (Pt 9)","key":"10.1016\/j.optom.2016.09.003_bib0625","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1093\/brain\/awp158","article-title":"Gene-environment interactions in Leber hereditary optic neuropathy","volume":"132","author":"Kirkman","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0630","first-page":"1218","article-title":"A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic aetiology","volume":"51","author":"Mackey","year":"1992","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0635","first-page":"10","article-title":"Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation","volume":"12","author":"Stone","year":"1992","journal-title":"J Clin Neuroophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0640","first-page":"10","article-title":"Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation","volume":"12","author":"Kline","year":"1992","journal-title":"J Clin Neuroophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0645","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1167\/iovs.06-0520","article-title":"Leber's hereditary optic neuropathy with childhood onset","volume":"47","author":"Barboni","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"May","key":"10.1016\/j.optom.2016.09.003_bib0650","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/eye.2014.37","article-title":"Treatment strategies for inherited optic neuropathies: past, present and future","volume":"28","author":"Yu-Wai-Man","year":"2014","journal-title":"Eye (Lond)"},{"issue":"Pt 4","key":"10.1016\/j.optom.2016.09.003_bib0655","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/brain\/115.4.979","article-title":"Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation","volume":"115","author":"Harding","year":"1992","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0660","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jns.2009.09.009","article-title":"Multiple sclerosis associated with Leber's hereditary optic neuropathy","volume":"286","author":"Palace","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.optom.2016.09.003_bib0665","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s004150070153","article-title":"Mitochondrial mutations of Leber's hereditary optic neuropathy: a risk factor for multiple sclerosis","volume":"247","author":"Vanopdenbosch","year":"2000","journal-title":"J Neurol"},{"key":"10.1016\/j.optom.2016.09.003_bib0670","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/ana.410360121","article-title":"Leber's hereditary optic neuropathy mitochondrial DNA mutations in multiple sclerosis","volume":"36","author":"Kellar-Wood","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/j.optom.2016.09.003_bib0675","series-title":"Genetic Risks: A Reference For Eye Care Practitioners","author":"Lyle","year":"1990"},{"key":"10.1016\/j.optom.2016.09.003_bib0680","first-page":"40","article-title":"Identification of the gene responsible for dominant optic atrophy (OPA1) on chromosome 3q28","volume":"67","author":"Alexander","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0685","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0690","first-page":"37","article-title":"Functions and dysfunctions of the human dynamin OPA1","volume":"1657","author":"Lenaers","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.optom.2016.09.003_bib0695","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/ana.21385","article-title":"Hereditary optic neuropathies share a common mitochondrial coupling defect","volume":"63","author":"Chevrollier","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.optom.2016.09.003_bib0700","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/brain\/awq007","article-title":"Multi-system neurological disease is common in patients with OPA1 mutations","volume":"133","author":"Yu-Wai-Man","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0705","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/15563650.2011.556642","article-title":"Outcomes of visual disturbances after methanol poisoning","volume":"49","author":"Sanaei-Zadeh","year":"2011","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.optom.2016.09.003_bib0710","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/OPX.0b013e31823ee128","article-title":"Methanol poisoning: ocular and neurological manifestations","volume":"89","author":"Sharma","year":"2012","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.optom.2016.09.003_bib0715","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1081\/CLT-120006745","article-title":"American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning","volume":"40","author":"Barceloux","year":"2002","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1016\/j.optom.2016.09.003_bib0720","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0732-8893(97)00217-4","article-title":"The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy","volume":"30","author":"Kozak","year":"1998","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.optom.2016.09.003_bib0725","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/0301-4738.77035","article-title":"Toxic optic neuropathy","volume":"59","author":"Sharma","year":"2011","journal-title":"Indian J Ophthalmol"},{"issue":"September","key":"10.1016\/j.optom.2016.09.003_bib0730","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1517\/14740338.5.5.615","article-title":"Update on ethambutol optic neuropathy","volume":"5","author":"Fraunfelder","year":"2006","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.optom.2016.09.003_bib0735","first-page":"80","article-title":"The incidence of optic neuropathy in 84 patients treated with ethambutol","volume":"2","author":"De Palma","year":"1989","journal-title":"Metab Pediatr Syst Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0740","first-page":"191","article-title":"Prevention of ocular toxicity of ethambutol: study of zincaemia and chromatic analysis","volume":"1","author":"Delacoux","year":"1978","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0745","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/pds.1320","article-title":"Complete blindness after optic neuropathy induced by short-term linezolid treatment in a patient suffering from muscle dystrophy","volume":"16","author":"Azamfirei","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.optom.2016.09.003_bib0750","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1086\/597298","article-title":"A case of optic neuropathy after short-term linezolid use in a patient with acute lymphocytic leukemia","volume":"48","author":"Joshi","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.optom.2016.09.003_bib0755","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00041327-200503000-00005","article-title":"Optic neuropathy associated with linezolid treatment","volume":"25","author":"McKinley","year":"2005","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0760","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1212\/01.wnl.0000201313.24970.b8","article-title":"Linezolid-associated toxic optic neuropathy","volume":"66","author":"Rucker","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.optom.2016.09.003_bib0765","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/bjo.2006.102541","article-title":"Linezolid-induced optic neuropathy: a mitochondrial disorder?","volume":"91","author":"Javaheri","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0770","first-page":"1011","article-title":"Optic neuritis and optic atrophy following chloramphenicol in cystic fibrosis patients","volume":"74","author":"Harley","year":"1970","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"10.1016\/j.optom.2016.09.003_bib0775","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.1980.01020040269011","article-title":"Chloramphenicol optic neuropathy","volume":"98","author":"Lazar","year":"1980","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0780","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1076\/soph.17.1.29.10290","article-title":"Metabolic optic neuropathies","volume":"17","author":"Sadun","year":"2002","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0785","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000048300","article-title":"Optic neuropathy from folic acid deficiency without alcohol abuse","volume":"216","author":"Hsu","year":"2002","journal-title":"Ophthalmologica"},{"issue":"1\u20132","key":"10.1016\/j.optom.2016.09.003_bib0790","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jns.2007.06.038","article-title":"Nutritional optic neuropathies","volume":"262","author":"Orssaud","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.optom.2016.09.003_bib0795","first-page":"848","article-title":"Nutritional amblyopia associated with jejunoileal bypass surgery","volume":"14","author":"Thompson","year":"1982","journal-title":"Ann Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0800","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1079\/BJN2001362","article-title":"Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic","volume":"85","author":"Arnaud","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1016\/j.optom.2016.09.003_bib0805","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1056\/NEJM199511023331803","article-title":"Epidemic optic neuropathy in Cuba \u2014 clinical characterization and risk factors","volume":"333","author":"The Cuba Neuropathy Field Investigation Team","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.optom.2016.09.003_bib0810","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1024\/0300-9831.70.3.126","article-title":"Vitamin and nutritional status in Cuban smokers and nonsmokers in the context of an emerging epidemic neuropathy","volume":"70","author":"Barnouin","year":"2000","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.optom.2016.09.003_bib0815","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00439-001-0645-7","article-title":"A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene","volume":"110","author":"Aung","year":"2002","journal-title":"Hum Genet"},{"issue":"February","key":"10.1016\/j.optom.2016.09.003_bib0820","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/jmg.2009.067512","article-title":"OPA1 increases the risk of normal but not high tension glaucoma","volume":"47","author":"Yu-Wai-Man","year":"2010","journal-title":"J Med Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0825","doi-asserted-by":"crossref","first-page":"e42387","DOI":"10.1371\/journal.pone.0042387","article-title":"Association of OPA1 polymorphisms with NTG and HTG: a meta-analysis","volume":"7","author":"Guo","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.optom.2016.09.003_bib0830","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0161-6420(00)00518-2","article-title":"Natural history of normal-tension glaucoma","volume":"108","author":"Anderson","year":"2001","journal-title":"Ophthalmology"},{"issue":"December","key":"10.1016\/j.optom.2016.09.003_bib0835","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00055735-200212000-00004","article-title":"Is normal tension glaucoma actually an unrecognized hereditary optic neuropathy? New evidence from genetic analysis","volume":"13","author":"Buono","year":"2002","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.optom.2016.09.003_bib0840","doi-asserted-by":"crossref","first-page":"e17963","DOI":"10.1371\/journal.pone.0017963","article-title":"NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels","volume":"6","author":"Haefeli","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.optom.2016.09.003_bib0845","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0140-6736(92)91442-B","article-title":"Remission of Lebers hereditary optic neuropathy with Idebenone","volume":"340","author":"Mashima","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.optom.2016.09.003_bib0850","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/brain\/awr170","article-title":"A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy","volume":"134","author":"Klopstock","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0855","first-page":"e260","article-title":"Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy","author":"Klopstock","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0860","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1093\/brain\/awr180","article-title":"Idebenone treatment in Leber's hereditary optic neuropathy","volume":"134","author":"Carelli","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0865","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1093\/brain\/aws280","article-title":"Idebenone treatment in patients with OPA1-mutant dominant optic atrophy","volume":"136","author":"Barboni","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0870","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1001\/archneurol.2011.2972","article-title":"Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy","volume":"69","author":"Sadun","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.optom.2016.09.003_bib0875","article-title":"Targeting mitochondrial function to treat optic neuropathy","author":"Gueven","year":"2016","journal-title":"Mitochondrion"},{"issue":"November","key":"10.1016\/j.optom.2016.09.003_bib0880","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/ana.10354","article-title":"Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy","volume":"52","author":"Guy","year":"2002","journal-title":"Ann Neurol"},{"issue":"October","key":"10.1016\/j.optom.2016.09.003_bib0885","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2008.04.018","article-title":"The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes","volume":"1783","author":"Bonnet","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.optom.2016.09.003_bib0890","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ajhg.2008.08.013","article-title":"Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction","volume":"83","author":"Ellouze","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0895","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1167\/iovs.08-3214","article-title":"Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system","volume":"50","author":"Guy","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.optom.2016.09.003_bib0900","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/nar\/gkq769","article-title":"Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?","volume":"39","author":"Perales-Clemente","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.optom.2016.09.003_bib0905","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/hum.2011.177","article-title":"Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells","volume":"23","author":"Iyer","year":"2012","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.optom.2016.09.003_bib0910","doi-asserted-by":"crossref","first-page":"E1238","DOI":"10.1073\/pnas.1119577109","article-title":"Gene delivery to mitochondria by targeting modified adeno-associated virus suppresses Leber's hereditary optic neuropathy in a mouse model","volume":"109","author":"Yu","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"March","key":"10.1016\/j.optom.2016.09.003_bib0915","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ophtha.2015.10.025","article-title":"Gene therapy for Leber hereditary optic neuropathy: initial results","volume":"123","author":"Feuer","year":"2016","journal-title":"Ophthalmology"},{"issue":"February","key":"10.1016\/j.optom.2016.09.003_bib0920","doi-asserted-by":"crossref","first-page":"21587","DOI":"10.1038\/srep21587","article-title":"Efficacy and safety of rAAV2-ND4 treatment for Leber's hereditary optic neuropathy","volume":"19","author":"Wan","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.optom.2016.09.003_bib0925","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/brain\/awm005","article-title":"A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy","volume":"130","author":"Alavi","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0930","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/hmg\/ddm079","article-title":"Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function","volume":"16","author":"Davies","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.optom.2016.09.003_bib0935","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/brain\/aws303","article-title":"The human OPA1(delTTAG) mutation induces premature age-related systemic neurodegeneration in mouse","volume":"135","author":"Sarzi","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.optom.2016.09.003_bib0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2016.06.004","article-title":"Emerging mitochondrial therapeutic targets in optic neuropathies","author":"Lopez Sanchez","year":"2016","journal-title":"Pharmacol Ther"}],"container-title":["Journal of Optometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1888429616300681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1888429616300681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:11:15Z","timestamp":1761822675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1888429616300681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1888429616300681"],"URL":"https:\/\/doi.org\/10.1016\/j.optom.2016.09.003","relation":{},"ISSN":["1888-4296"],"issn-type":[{"value":"1888-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired Forms","name":"articletitle","label":"Article Title"},{"value":"Journal of Optometry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.optom.2016.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Spanish General Council of Optometry.","name":"copyright","label":"Copyright"}]}}