{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:21:27Z","timestamp":1777918887127,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research &amp; Clinical Practice"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.orcp.2007.12.001","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T12:05:40Z","timestamp":1202731540000},"page":"43-50","source":"Crossref","is-referenced-by-count":12,"title":["Acanthosis Nigricans and insulin levels in a south Indian population\u2014(ADEPS paper 2)"],"prefix":"10.1016","volume":"2","author":[{"given":"V. Usha","family":"Menon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Gilchrist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.R.","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.V.","family":"Jayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasantha","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.orcp.2007.12.001_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1515\/JBCPP.1998.9.2-4.407","article-title":"Acanthosis Nigricans","volume":"9","author":"Stuart","year":"1998","journal-title":"Basic Clin Physiol Pharmacol"},{"key":"10.1016\/j.orcp.2007.12.001_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0100-879X2002000100008","article-title":"Association of Acanthosis Nigricans with race and metabolic disturbances in obese women","volume":"35","author":"Araujo","year":"2002","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.orcp.2007.12.001_bib3","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1210\/jc.2004-0276","article-title":"Insulin resistance syndrome in children","volume":"89","author":"Ten","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.orcp.2007.12.001_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4158\/EP.10.2.101","article-title":"Prevalence of Acanthosis Nigricans in newly diagnosed type 2 diabetes","volume":"10","author":"Litonjua","year":"2004","journal-title":"Endocr Pract"},{"key":"10.1016\/j.orcp.2007.12.001_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/000992289803700203","article-title":"Acanthosis Nigricans as a risk factor for non-insulin dependent diabetes mellitus","volume":"37","author":"Stuart","year":"1998","journal-title":"Clin Pediatr"},{"key":"10.1016\/j.orcp.2007.12.001_bib6","first-page":"523","article-title":"Hyperinsulinemia and Acanthosis Nigricans in African Americans","volume":"89","author":"Stuart","year":"1997","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.orcp.2007.12.001_bib7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0002-9343(87)90903-X","article-title":"Spectrum of endocrine abnormalities associated with Acanthosis Nigricans","volume":"83","author":"Matsuoka","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.orcp.2007.12.001_bib8","first-page":"193","article-title":"Insulin resistance the clinical spectrum","volume":"6","author":"Mantzoros","year":"1995","journal-title":"Adv Endocrinol Metab"},{"key":"10.1016\/j.orcp.2007.12.001_bib9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1083\/jcb.200011148","article-title":"Impaired skin wound healing in peroxisome proliferator activated receptor (PPAR)( and ( mutant mice","volume":"154","author":"Michalik","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.orcp.2007.12.001_bib10","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1101\/gad.207501","article-title":"Critical roles of PPAR (\/( in keratinocyte response to inflammation","volume":"15","author":"Tan","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.orcp.2007.12.001_bib11","first-page":"774","article-title":"Insulin resistance and polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.orcp.2007.12.001_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0020-7292(00)00282-4","article-title":"Association of Acanthosis Nigricans with risk of diabetes mellitus and hormonal disturbance in females","volume":"71","author":"Lestringant","year":"2000","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.orcp.2007.12.001_bib13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1742-1241.2002.tb11327.x","article-title":"Therapeutic approach in insulin resistance with Acanthosis Nigricans","volume":"56","author":"Tankova","year":"2002","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.orcp.2007.12.001_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/09513590500216776","article-title":"Acanthosis Nigricans clinical predicter of abnormal glucose tolerance in Asian women with polycystic ovary syndrome","volume":"21","author":"Charnvises","year":"2005","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.orcp.2007.12.001_bib15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/pgmj.2004.028308","article-title":"Acanthosis Nigricans: relation with type 2 diabetes mellitus, anthropometric variables and body mass index in Indians","volume":"81","author":"Grandhe","year":"2005","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.orcp.2007.12.001_bib16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s001250050668","article-title":"Rising prevalence of NIDDM in an urban population in India","volume":"40","author":"Ramachandran","year":"1997","journal-title":"Diabetolgia"},{"key":"10.1016\/j.orcp.2007.12.001_bib17","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s001250100627","article-title":"A high prevalence of diabetes and impaired glucose tolerance in India. National Urban Diabetes Survey","volume":"44","author":"Ramachandran","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.orcp.2007.12.001_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.diabres.2006.03.025","article-title":"Prevalence of known and undetected diabetes and associated risk factors in central Kerala\u2014ADEPS","volume":"74","author":"Menon","year":"2006","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.orcp.2007.12.001_bib19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2337\/diacare.25.6.1009","article-title":"Association of Acanthosis Nigricans with hyperinsulinemia compared with other selected risk factors for type 2 diabetes in Cherokee Indians","volume":"25","author":"Stoddart","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.orcp.2007.12.001_bib20","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2337\/diacare.26.5.1380","article-title":"Cut off values for normal anthropometric variables in Asian Indian adults","volume":"26","author":"Snehalatha","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.orcp.2007.12.001_bib21","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of high blood pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.orcp.2007.12.001_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabetes Med"},{"key":"10.1016\/j.orcp.2007.12.001_bib23","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III)","volume":"285","author":"Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.orcp.2007.12.001_bib24","first-page":"19","article-title":"Acanthosis Nigricans, insulin resistance (HOMA) and dyslipidaemia among Native American children","volume":"99","author":"Copeland","year":"2006","journal-title":"J Okla State Med Assoc"},{"key":"10.1016\/j.orcp.2007.12.001_bib25","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.2105\/AJPH.84.11.1839","article-title":"Acanthosis Nigricans among native Americans an Indicator of high diabetes risk","volume":"84","author":"Stuart","year":"1994","journal-title":"Am J Pub Health"},{"key":"10.1016\/j.orcp.2007.12.001_bib26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0002-9343(89)80149-4","article-title":"Prevalence of Acanthosis Nigricans in an unselected population","volume":"87","author":"Stuart","year":"1989","journal-title":"Am J Med"},{"key":"10.1016\/j.orcp.2007.12.001_bib27","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.2337\/diacare.27.8.1998","article-title":"Impact of degree of obesity on surrogate estimates of insulin resistance","volume":"27","author":"Kim","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.orcp.2007.12.001_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1442-200X.2003.01812.x","article-title":"Acanthosis Nigricans is a reliable cutaneous marker of insulin resistance in obese Japanese children","volume":"45","author":"Yamazaki","year":"2003","journal-title":"Pediatr Int"},{"key":"10.1016\/j.orcp.2007.12.001_bib29","first-page":"705","article-title":"A study of insulin resistance in subjects with Acanthosis Nigricans","volume":"49","author":"Varthakavi","year":"2001","journal-title":"J Assoc Physicians India"}],"container-title":["Obesity Research &amp; Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X0700083X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X0700083X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T08:02:39Z","timestamp":1708588959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X0700083X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1871403X0700083X"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2007.12.001","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}