{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:53:58Z","timestamp":1790553238863,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research &amp; Clinical Practice"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.orcp.2008.06.001","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T08:31:13Z","timestamp":1216801873000},"page":"231-238","source":"Crossref","is-referenced-by-count":42,"title":["Circulating levels of ganglioside GM3 in metabolic syndrome: A pilot study"],"prefix":"10.1016","volume":"2","author":[{"given":"Takashige","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nihei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Nagafuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunobu","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-ichi","family":"Sugahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-ichi","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.orcp.2008.06.001_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1146\/annurev.bi.50.070181.003505","article-title":"Glycosphingolipids in cellular interaction, differentiation, and oncogenesis","volume":"50","author":"Hakomori","year":"1981","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.orcp.2008.06.001_bib2","first-page":"733","article-title":"Receptor modifications in glycobiology","volume":"vol. 3","author":"Inokuchi","year":"2007"},{"key":"10.1016\/j.orcp.2008.06.001_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/glycob\/cwh135","article-title":"TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3","volume":"15","author":"Kabayama","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.orcp.2008.06.001_bib4","doi-asserted-by":"crossref","first-page":"13678","DOI":"10.1073\/pnas.0703650104","article-title":"Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance","volume":"104","author":"Kabayama","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.orcp.2008.06.001_bib5","doi-asserted-by":"crossref","first-page":"27896","DOI":"10.1074\/jbc.M212200200","article-title":"Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice","volume":"278","author":"Sasaki","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.orcp.2008.06.001_bib6","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1016\/S0021-9258(18)68515-1","article-title":"Neolacto-series gangliosides induce granulocytic differentiation of human promyelocytic leukemia cell line HL-60","volume":"263","author":"Nojiri","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.orcp.2008.06.001_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF02533566","article-title":"A comparison of the ganglioside distributions of fat tissues in various animals by two-dimensional thin layer chromatography","volume":"14","author":"Ohashi","year":"1979","journal-title":"Lipids"},{"key":"10.1016\/j.orcp.2008.06.001_bib8","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1074\/jbc.M103705200","article-title":"Ganglioside GM3 participates in the pathological conditions of insulin resistance","volume":"277","author":"Tagami","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.orcp.2008.06.001_bib9","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1073\/pnas.0635898100","article-title":"Enhanced insulin sensitivity in mice lacking ganglioside GM3","volume":"100","author":"Yamashita","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.orcp.2008.06.001_bib10","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/db06-0719","article-title":"Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes","volume":"56","author":"Zhao","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2008.06.001_bib11","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2337\/db06-1619","article-title":"Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity","volume":"56","author":"Aerts","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2008.06.001_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1432-1033.1989.tb14773.x","article-title":"Gangliosides in normal human serum. Concentration, pattern and transport by lipoproteins","volume":"181","author":"Senn","year":"1989","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.orcp.2008.06.001_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0021-9150(92)90235-9","article-title":"Human serum gangliosides in hypercholesterolemia, before and after extracorporeal elimination of LDL","volume":"94","author":"Senn","year":"1992","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.orcp.2008.06.001_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02537083","article-title":"Gangliosides and atherosclerosis","volume":"29","author":"Prokazova","year":"1994","journal-title":"Lipids"},{"key":"10.1016\/j.orcp.2008.06.001_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0022-2275(20)30162-0","article-title":"Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice","volume":"43","author":"Garner","year":"2002","journal-title":"J Lipid Res"},{"key":"10.1016\/j.orcp.2008.06.001_bib16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/clinchem\/47.2.266","article-title":"Development of a rapid, quantitative method for LDL subfractionation with use of the Quantimetrix Lipoprint LDL System","volume":"47","author":"Hoefner","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.orcp.2008.06.001_bib17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2169\/internalmedicine.38.202","article-title":"Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity","volume":"38","author":"Funahashi","year":"1999","journal-title":"Intern Med"},{"key":"10.1016\/j.orcp.2008.06.001_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/CS20050182","article-title":"Adiponectin: a key adipocytokine in metabolic syndrome","volume":"110","author":"Okamoto","year":"2006","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.orcp.2008.06.001_bib19","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/oby.2002.150","article-title":"Plasma adiponectin levels in overweight and obese Asians","volume":"10","author":"Yang","year":"2002","journal-title":"Obes Res"},{"key":"10.1016\/j.orcp.2008.06.001_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1055\/s-2007-1009213","article-title":"Lipid-bound sialic acid in diabetes","volume":"21","author":"Gavella","year":"1989","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.orcp.2008.06.001_bib21","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/jama.1988.03410130125037","article-title":"Low-density lipoprotein subclass patterns and risk of myocardial infarction","volume":"260","author":"Austin","year":"1988","journal-title":"JAMA"},{"key":"10.1016\/j.orcp.2008.06.001_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.ATV.11.2.298","article-title":"Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects","volume":"11","author":"de Graaf","year":"1991","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.orcp.2008.06.001_bib23","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-2275(20)40052-5","article-title":"Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions","volume":"36","author":"Tribble","year":"1995","journal-title":"J Lipid Res"},{"key":"10.1016\/j.orcp.2008.06.001_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0925-4439(97)00044-6","article-title":"Incorporation and localisation of ganglioside GM3 in human intimal atherosclerotic lesions","volume":"1361","author":"Bobryshev","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.orcp.2008.06.001_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0925-4439(00)00076-4","article-title":"Phenotype determination of anti-GM3 positive cells in atherosclerotic lesions of the human aorta. Hypothetical role of ganglioside GM3 in foam cell formation","volume":"1535","author":"Bobryshev","year":"2001","journal-title":"Biochim Biophys Acta"}],"container-title":["Obesity Research &amp; Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X08000525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X08000525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T18:16:17Z","timestamp":1631556977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X08000525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1871403X08000525"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2008.06.001","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}