{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:20:49Z","timestamp":1770438049395,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","obesityresearchclinicalpractice.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Research &amp; Clinical Practice"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.orcp.2015.01.003","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T13:33:35Z","timestamp":1422711215000},"page":"293-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5488-2622","authenticated-orcid":false,"given":"Motoh","family":"Iwasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Mifuji-Moroka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.orcp.2015.01.003_bib0085","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2337\/db13-0185","article-title":"Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism","volume":"62","author":"Magkos","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2015.01.003_bib0090","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.metabol.2010.03.006","article-title":"Plasma metabolomic profile in nonalcoholic fatty liver disease","volume":"60","author":"Kalhan","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.orcp.2015.01.003_bib0095","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.metabol.2013.01.007","article-title":"Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness","volume":"62","author":"Batch","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.orcp.2015.01.003_bib0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2007.08.003","article-title":"Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle","volume":"6","author":"She","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2015.01.003_bib0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2015.01.003_bib0110","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"Wang","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.orcp.2015.01.003_bib0115","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/aje\/kwt112","article-title":"Branched-chain amino acid intake and the risk of diabetes in a Japanese community: the Takayama study","volume":"178","author":"Nagata","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.orcp.2015.01.003_bib0120","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1253\/circj.66.987","article-title":"Japan Society for the Study of Obesity. New criteria for \u2018obesity disease\u2019 in Japan","volume":"66","author":"Examination Committee of Criteria for \u2018Obesity Disease\u2019 in Japan","year":"2002","journal-title":"Circ J"},{"key":"10.1016\/j.orcp.2015.01.003_bib0125","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/clinchem\/35.7.1399","article-title":"Determination of branched-chain amino acids and tyrosine in serum of patients with various hepatic diseases, and its clinical usefulness","volume":"35","author":"Azuma","year":"1989","journal-title":"Clin Chem"},{"key":"10.1016\/j.orcp.2015.01.003_bib0130","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00726-011-1088-7","article-title":"Insulin resistance and the metabolism of branched-chain amino acids in humans","volume":"43","author":"Adeva","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.orcp.2015.01.003_bib0135","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hep.1840080509","article-title":"Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis","volume":"8","author":"Montanari","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.orcp.2015.01.003_bib0140","doi-asserted-by":"crossref","first-page":"e70309","DOI":"10.1371\/journal.pone.0070309","article-title":"Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis","volume":"8","author":"Iwasa","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.orcp.2015.01.003_bib0145","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cmet.2010.08.016","article-title":"Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice","volume":"12","author":"D\u2019Antona","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2015.01.003_bib0150","doi-asserted-by":"crossref","first-page":"E1552","DOI":"10.1152\/ajpendo.00134.2007","article-title":"Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism","volume":"293","author":"She","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.orcp.2015.01.003_bib0155","doi-asserted-by":"crossref","first-page":"E164","DOI":"10.1152\/ajpendo.00219.2010","article-title":"Multi-tissue, selective PPAR\u03b3 modulation of insulin sensitivity and metabolic pathways in obese rats","volume":"300","author":"Hsiao","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.orcp.2015.01.003_bib0160","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.metabol.2013.07.003","article-title":"Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus","volume":"62","author":"Walford","year":"2013","journal-title":"Metabolism"}],"container-title":["Obesity Research &amp; Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X15000046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X15000046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T14:29:11Z","timestamp":1598711351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X15000046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1871403X15000046"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2015.01.003","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment","name":"articletitle","label":"Article Title"},{"value":"Obesity Research & Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.orcp.2015.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}