{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:36:03Z","timestamp":1790271363467,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Research &amp; Clinical Practice"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.orcp.2019.07.001","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:13:52Z","timestamp":1562804032000},"page":"408-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese"],"prefix":"10.1016","volume":"13","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy T.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbell H.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie K.","family":"Heilbronn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.orcp.2019.07.001_bib0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-nutr-071812-161113","article-title":"Macrophages and the regulation of adipose tissue remodeling","volume":"34","author":"Martinez-Santibanez","year":"2014","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.orcp.2019.07.001_bib0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI88880","article-title":"Skeletal muscle inflammation and insulin resistance in obesity","volume":"127","author":"Wu","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.orcp.2019.07.001_bib0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.orcp.2019.07.001_bib0020","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/oby.20615","article-title":"Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans","volume":"22","author":"Fink","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.orcp.2019.07.001_bib0025","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cmet.2013.06.016","article-title":"Fibrosis and adipose tissue dysfunction","volume":"18","author":"Sun","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0030","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.2337\/db10-0585","article-title":"Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss","volume":"59","author":"Divoux","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2019.07.001_bib0035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ajcn\/78.3.361","article-title":"Calorie restriction and aging: review of the literature and implications for studies in humans","volume":"78","author":"Heilbronn","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.orcp.2019.07.001_bib0040","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2337\/dc05-2565","article-title":"Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects","volume":"29","author":"Larson-Meyer","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.orcp.2019.07.001_bib0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2337\/db16-0500","article-title":"Macrophage proliferation sustains adipose tissue inflammation in formerly obese mice","volume":"66","author":"Zamarron","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2019.07.001_bib0050","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cmet.2016.07.023","article-title":"Caloric restriction leads to browning of white adipose tissue through type 2 immune signaling","volume":"24","author":"Fabbiano","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0055","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1172\/JCI42845","article-title":"Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue","volume":"120","author":"Kosteli","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.orcp.2019.07.001_bib0060","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1038\/s41598-017-04896-y","article-title":"The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent","volume":"7","author":"Boldrin","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.orcp.2019.07.001_bib0065","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cmet.2016.02.005","article-title":"Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity","volume":"23","author":"Magkos","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0070","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.2337\/db09-0033","article-title":"Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization","volume":"58","author":"Capel","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2019.07.001_bib0075","first-page":"1","article-title":"Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans","author":"Liu","year":"2017","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0080","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.celrep.2015.12.042","article-title":"Long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle","volume":"14","author":"Yang","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.orcp.2019.07.001_bib0085","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jn\/136.2.343","article-title":"Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue","volume":"136","author":"Higami","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.orcp.2019.07.001_bib0090","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jnutbio.2008.11.001","article-title":"Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction","volume":"21","author":"Varady","year":"2010","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.orcp.2019.07.001_bib0095","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1210\/en.2015-1622","article-title":"Intermittent fasting promotes fat loss with lean mass retention, increased hypothalamic norepinephrine content, and increased neuropeptide Y gene expression in diet-induced obese male mice","volume":"157","author":"Gotthardt","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.orcp.2019.07.001_bib0100","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jama.295.13.1539","article-title":"Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial","volume":"295","author":"Heilbronn","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.orcp.2019.07.001_bib0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ajcn\/81.1.69","article-title":"Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism","volume":"81","author":"Heilbronn","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.orcp.2019.07.001_bib0110","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/jamainternmed.2017.0936","article-title":"Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults: a randomized clinical trial","volume":"177","author":"Trepanowski","year":"2017","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.orcp.2019.07.001_bib0115","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1194\/jlr.M021725","article-title":"Lack of \u201cimmunological fitness\u201d during fasting in metabolically challenged animals","volume":"53","author":"Asterholm","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1016\/j.orcp.2019.07.001_bib0120","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1038\/ncomms11533","article-title":"Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16","volume":"7","author":"Ding","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.orcp.2019.07.001_bib0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/oby.22345","article-title":"Effects of intermittent versus continuous energy intakes on insulin sensitivity and metabolic risk in women with overweight","volume":"27","author":"Hutchison","year":"2019","journal-title":"Obesity"},{"key":"10.1016\/j.orcp.2019.07.001_bib0130","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.2337\/db10-0162","article-title":"Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans","volume":"59","author":"Tam","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.orcp.2019.07.001_bib0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.metabol.2016.10.009","article-title":"Skeletal muscle extracellular matrix remodeling after short-term overfeeding in healthy humans","volume":"67","author":"Tam","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.orcp.2019.07.001_bib0140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000452678","article-title":"Acute overfeeding does not alter liver or adipose tissue-derived cytokines in healthy humans","volume":"69","author":"Chen","year":"2016","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0145","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1582-4934.2007.00031.x","article-title":"The extracellular matrix and blood vessel formation: not just a scaffold","volume":"11","author":"Rhodes","year":"2007","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.orcp.2019.07.001_bib0150","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1210\/jc.2009-0925","article-title":"Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss","volume":"94","author":"Aron-Wisnewsky","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0155","article-title":"The roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance in modest obesity and early metabolic dysfunction","volume":"11","author":"Kang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.orcp.2019.07.001_bib0160","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cmet.2014.08.010","article-title":"Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages","volume":"20","author":"Kratz","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0165","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1016\/j.celrep.2017.08.096","article-title":"Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity","volume":"20","author":"Coats","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.orcp.2019.07.001_bib0170","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00125-017-4526-6","article-title":"Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses","volume":"61","author":"Boutens","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.orcp.2019.07.001_bib0175","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.orcp.2019.07.001_bib0180","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.orcp.2019.07.001_bib0185","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/jcp.27012","article-title":"Proinflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of tumor necrosis factor-\u03b1 via sustained activation of p38 mitogen-activated protein kinase","volume":"234","author":"Wang","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.orcp.2019.07.001_bib0190","first-page":"58","article-title":"Little evidence of systemic and adipose tissue inflammation in overweight individuals(dagger)","volume":"3","author":"Tam","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.orcp.2019.07.001_bib0195","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/ajcn\/nqy196","article-title":"Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial","volume":"108","author":"Sch\u00fcbel","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.orcp.2019.07.001_bib0200","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/en.2018-00701","article-title":"Intermittent fasting improves glucose tolerance and promotes adipose tissue remodeling in male mice fed a high-fat diet","volume":"160","author":"Liu","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.orcp.2019.07.001_bib0205","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00125-015-3719-0","article-title":"Fatty acids from fat cell lipolysis do not activate an inflammatory response but are stored as triacylglycerols in adipose tissue macrophages","volume":"58","author":"Caspar-Bauguil","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.orcp.2019.07.001_bib0210","first-page":"142","article-title":"Free fatty acids and insulin resistance","volume":"10","author":"Delarue","year":"2007","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.orcp.2019.07.001_bib0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.diabet.2016.10.004","article-title":"Evolution of subcutaneous adipose tissue fibrosis after bariatric surgery","volume":"43","author":"Chabot","year":"2017","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0220","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/jc.2015-3348","article-title":"Accumulation and changes in composition of collagens in subcutaneous adipose tissue after bariatric surgery","volume":"101","author":"Liu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.orcp.2019.07.001_bib0225","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/cr.2017.126","article-title":"Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage","volume":"27","author":"Kim","year":"2017","journal-title":"Cell Res"},{"key":"10.1016\/j.orcp.2019.07.001_bib0230","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1111\/febs.14417","article-title":"Chronic inflammation in skeletal muscle impairs satellite cells function during regeneration: can physical exercise restore the satellite cell niche?","volume":"285","author":"Perandini","year":"2018","journal-title":"FEBS J"},{"key":"10.1016\/j.orcp.2019.07.001_bib0235","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbrc.2013.10.005","article-title":"Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle","volume":"441","author":"Ikeda","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.orcp.2019.07.001_bib0240","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"Mann","year":"2011","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.orcp.2019.07.001_bib0245","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ajpath.2013.12.020","article-title":"Altered macrophage phenotype transition impairs skeletal muscle regeneration","volume":"184","author":"Wang","year":"2014","journal-title":"Am J Pathol"}],"container-title":["Obesity Research &amp; Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X19302248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X19302248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:26:40Z","timestamp":1761730000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X19302248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1871403X19302248"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2019.07.001","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese","name":"articletitle","label":"Article Title"},{"value":"Obesity Research & Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.orcp.2019.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity. All rights reserved.","name":"copyright","label":"Copyright"}]}}