{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:10:44Z","timestamp":1767006644612,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1074383","1106016","209057","396414"],"award-info":[{"award-number":["1074383","1106016","209057","396414"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000951","name":"Cancer Council Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001231","name":"VicHealth","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007220","name":"VicHealth","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Research & Clinical Practice"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.orcp.2023.04.004","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T17:38:14Z","timestamp":1682703494000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adiposity and plasma concentrations of kynurenine pathway metabolites and traditional markers of inflammation"],"prefix":"10.1016","volume":"17","author":[{"given":"Mengmei E.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison M.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherly X.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa C.","family":"Southey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Antoine","family":"Dugu\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.orcp.2023.04.004_bib1","doi-asserted-by":"crossref","first-page":"17034","DOI":"10.1038\/nrdp.2017.34","article-title":"Obesity","volume":"3","author":"Gonzalez-Muniesa","year":"2017","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.orcp.2023.04.004_bib2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The epidemiology of obesity: a big picture","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.orcp.2023.04.004_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/678159","article-title":"Obesity and inflammation: epidemiology, risk factors, and markers of inflammation","volume":"2013","author":"Rodriguez-Hernandez","year":"2013","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.orcp.2023.04.004_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.5114\/aoms.2016.58928","article-title":"Obesity and inflammation: the linking mechanism and the complications","volume":"13","author":"Ellulu","year":"2017","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.orcp.2023.04.004_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/aje\/kwv242","article-title":"Plasma biomarkers of inflammation, the kynurenine pathway, and risks of all-cause, cancer, and cardiovascular disease mortality: the hordaland health study","volume":"183","author":"Zuo","year":"2016","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.orcp.2023.04.004_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41581-019-0145-4","article-title":"Obesity, kidney dysfunction and hypertension: mechanistic links","volume":"15","author":"Hall","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.orcp.2023.04.004_bib7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.imlet.2018.01.006","article-title":"Involvement of cystatin C in immunity and apoptosis","volume":"196","author":"Zi","year":"2018","journal-title":"Immunol Lett"},{"key":"10.1016\/j.orcp.2023.04.004_bib8","series-title":"Cystatin C: A Marker of Renal Function Or Something More?","first-page":"293","author":"Curhan","year":"2005"},{"key":"10.1016\/j.orcp.2023.04.004_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1373\/clinchem.2004.041889","article-title":"Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate","volume":"51","author":"Koenig","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.orcp.2023.04.004_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.orcp.2023.04.004_bib11","first-page":"357","article-title":"Kynurenines: tryptophan's metabolites in exercise","author":"Cervenka","year":"2017","journal-title":"Inflamm, Ment Health Sci"},{"key":"10.1016\/j.orcp.2023.04.004_bib12","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1096\/fasebj.5.11.1907934","article-title":"Relationship between interferon\u2010\u03b3, indoleamine 2, 3\u2013dioxygenase, and tryptophan catabolism","volume":"5","author":"Taylor","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.orcp.2023.04.004_bib13","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1007\/s00125-017-4329-9","article-title":"The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease","volume":"60","author":"Rebnord","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.orcp.2023.04.004_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/ajcn\/nqz228","article-title":"Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients","volume":"111","author":"Ulvik","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.orcp.2023.04.004_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ajcn\/nqx012","article-title":"The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK)","volume":"107","author":"Zuo","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.orcp.2023.04.004_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192169","article-title":"Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery","volume":"13","author":"Christensen","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.orcp.2023.04.004_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/oby.20491","article-title":"Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome","volume":"22","author":"Mangge","year":"2014","journal-title":"Obes (Silver Spring)"},{"key":"10.1016\/j.orcp.2023.04.004_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fimmu.2020.00557","article-title":"Tryptophan metabolic pathways are altered in obesity and are associated with systemic inflammation","volume":"11","author":"Cussotto","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.orcp.2023.04.004_bib19","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/oby.21199","article-title":"The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation","volume":"23","author":"Favennec","year":"2015","journal-title":"Obes (Silver Spring)"},{"key":"10.1016\/j.orcp.2023.04.004_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyx085","article-title":"Cohort profile: the Melbourne collaborative cohort study (health 2020)","volume":"46","author":"Milne","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.orcp.2023.04.004_bib21","article-title":"Association of markers of inflammation, the kynurenine pathway and B vitamins with age and mortality, and a signature of inflammaging","author":"Dugu\u00e9","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.orcp.2023.04.004_bib22","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/jn\/nxab231","article-title":"Inflammation-related marker profiling of dietary patterns and all-cause mortality in the melbourne collaborative cohort study","volume":"151","author":"Li","year":"2021","journal-title":"J Nutr"},{"key":"10.1016\/j.orcp.2023.04.004_bib23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/15592294.2019.1668739","article-title":"Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility","volume":"15","author":"Dugu\u00e9","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.orcp.2023.04.004_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12855","article-title":"Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data","volume":"26","author":"Dugu\u00e9","year":"2021","journal-title":"Addict Biol"},{"key":"10.1016\/j.orcp.2023.04.004_bib25","doi-asserted-by":"crossref","first-page":"459S","DOI":"10.1093\/ajcn\/64.3.459S","article-title":"Applications of bioelectrical impedance analysis for body composition to epidemiologic studies","volume":"64","author":"Roubenoff","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.orcp.2023.04.004_bib26","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/rcm.4013","article-title":"Quantitative profiling of biomarkers related to B\u2010vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography\/tandem mass spectrometry","volume":"23","author":"Midttun","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.orcp.2023.04.004_bib27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3945\/jn.113.189738","volume":"144","author":"Midttun","year":"2014","journal-title":"J Nutr"},{"key":"10.1016\/j.orcp.2023.04.004_bib28","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1021\/acs.analchem.7b04975","article-title":"Multiplex immuno-MALDI-TOF MS for targeted quantification of protein biomarkers and their proteoforms related to inflammation and renal dysfunction","volume":"90","author":"Gao","year":"2018","journal-title":"Anal Chem"},{"key":"10.1016\/j.orcp.2023.04.004_bib29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1249\/MSS.0000000000001827","article-title":"Physical activity, television viewing time, and DNA methylation in peripheral blood","volume":"51","author":"van Roekel","year":"2019","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.orcp.2023.04.004_bib30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.numecd.2010.10.014","article-title":"Does a Mediterranean diet reduce the mortality risk associated with diabetes: evidence from the Melbourne collaborative cohort study","volume":"21","author":"Hodge","year":"2011","journal-title":"Nutr, Metab Cardiovasc Dis"},{"key":"10.1016\/j.orcp.2023.04.004_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest\u2014non-parametric missing value imputation for mixed-type data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.orcp.2023.04.004_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cei.12092","article-title":"A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland health study","volume":"173","author":"Theofylaktopoulou","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.orcp.2023.04.004_bib33","unstructured":"Bevital. \u3008https:\/\/bevital.no\/key-data\/.2021\u3009."},{"year":"1992","series-title":"Principles of Exposure Measurement in Epidemiology","author":"Armstrong BKW","key":"10.1016\/j.orcp.2023.04.004_bib34"},{"key":"10.1016\/j.orcp.2023.04.004_bib35","doi-asserted-by":"crossref","first-page":"13805","DOI":"10.1038\/s41598-021-93214-8","article-title":"Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults","volume":"11","author":"Zahed","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.orcp.2023.04.004_bib36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ejca.2015.01.057","article-title":"Obesity in breast cancer\u2013what is the risk factor?","volume":"51","author":"James","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.orcp.2023.04.004_bib37","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/ijc.32555","article-title":"Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the lung cancer cohort consortium (LC3)","volume":"146","author":"Huang","year":"2020","journal-title":"Int J Cancer"}],"container-title":["Obesity Research & Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X23000285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X23000285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:30:23Z","timestamp":1761730223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X23000285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1871403X23000285"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2023.04.004","relation":{},"ISSN":["1871-403X"],"issn-type":[{"type":"print","value":"1871-403X"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adiposity and plasma concentrations of kynurenine pathway metabolites and traditional markers of inflammation","name":"articletitle","label":"Article Title"},{"value":"Obesity Research & Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.orcp.2023.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.","name":"copyright","label":"Copyright"}]}}