{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:26:19Z","timestamp":1790292379519,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Research & Clinical Practice"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.orcp.2023.11.001","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T04:27:31Z","timestamp":1700886451000},"page":"458-467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nonhepatic hyperammonemic encephalopathy following bariatric surgery: A systematic review"],"prefix":"10.1016","volume":"17","author":[{"given":"Nasser","family":"Sakran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-7692","authenticated-orcid":false,"given":"Sjaak","family":"Pouwels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.orcp.2023.11.001_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.gtc.2016.07.012","article-title":"Obesity epidemiology worldwide","volume":"45","author":"Arroyo-Johnson","year":"2016","journal-title":"Gastroenterol Clin North Am"},{"issue":"2 Suppl","key":"10.1016\/j.orcp.2023.11.001_bib2","doi-asserted-by":"crossref","first-page":"560S","DOI":"10.1093\/ajcn\/55.2.560s","article-title":"Gastric bypass for treating severe obesity","volume":"55","author":"Sugerman","year":"1992","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.orcp.2023.11.001_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0002-9610(99)80177-9","article-title":"The role of gastric surgery in the multidisciplinary management of severe obesity","volume":"169","author":"Benotti","year":"1995","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.orcp.2023.11.001_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.sla.0000129280.68540.76","article-title":"A clinical and nutritional comparison of biliopancreatic diversion with and without duodenal switch","volume":"240","author":"Dolan","year":"2004","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.orcp.2023.11.001_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10040674","article-title":"Bariatric surgery-how much malabsorption do we need?-A review of various limb lengths in different gastric bypass procedures","volume":"10","author":"Felsenreich","year":"2021","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.orcp.2023.11.001_bib6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/mus.20394","article-title":"Neurologic complications after surgery for obesity","volume":"33","author":"Koffman","year":"2006","journal-title":"Muscle Nerve"},{"issue":"8","key":"10.1016\/j.orcp.2023.11.001_bib7","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1212\/01.WNL.0000142038.43946.06","article-title":"A controlled study of peripheral neuropathy after bariatric surgery","volume":"63","author":"Thaisetthawatkul","year":"2004","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.orcp.2023.11.001_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/oby.21037","article-title":"Hyperammonemic syndrome after Roux-en-Y gastric bypass","volume":"23","author":"Fenves","year":"2015","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.orcp.2023.11.001_bib9","first-page":"41","article-title":"Late presentation of fatal hyperammonemic encephalopathy after Roux-en-Y gastric bypass","volume":"30","author":"Nagarur","year":"2017","journal-title":"Proc (Bayl Univ Med Cent)"},{"issue":"12","key":"10.1016\/j.orcp.2023.11.001_bib10","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1007\/s11695-019-04231-6","article-title":"Recurrent hyperammonemia during enteral tube feeding for severe protein malnutrition after bariatric surgery","volume":"29","author":"Hendrikx","year":"2019","journal-title":"Obes Surg"},{"issue":"12","key":"10.1016\/j.orcp.2023.11.001_bib11","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1016\/j.asjsur.2022.06.044","article-title":"Nonhepatic hyperammonemic encephalopathy (NHE) after bariatric and metabolic surgery: a clinically challenging diagnosis","volume":"45","author":"Pouwels","year":"2022","journal-title":"Asian J Surg"},{"key":"10.1016\/j.orcp.2023.11.001_bib12","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ (Clin Res Ed)"},{"issue":"8","key":"10.1016\/j.orcp.2023.11.001_bib13","article-title":"Hyperammonemic encephalopathy: a complication of gastric bypass surgery","volume":"12","author":"Reddy","year":"2020","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.orcp.2023.11.001_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/kjm2.12032","article-title":"Hyperammonemic encephalopathy in a pediatric patient with Salmonella enteritis and after Roux-en-Y surgery","volume":"35","author":"Wu","year":"2019","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.orcp.2023.11.001_bib15","first-page":"8531591","article-title":"Fatal nonhepatic hyperammonemia in ICU setting: a rare but serious complication following bariatric surgery","volume":"2016","author":"Acharya","year":"2016","journal-title":"Case Rep Crit Care"},{"issue":"8","key":"10.1016\/j.orcp.2023.11.001_bib16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/0148607114546900","article-title":"Treating every needle in the haystack: hyperammonemic encephalopathy and severe malnutrition After bariatric surgery-a case report and review of the literature","volume":"39","author":"Singh","year":"2015","journal-title":"JPEN J Parenter Enter Nutr"},{"issue":"7","key":"10.1016\/j.orcp.2023.11.001_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.4254\/wjh.v7.i7.1007","article-title":"Hyperammonemia-induced encephalopathy: a rare devastating complication of bariatric surgery","volume":"7","author":"Kromas","year":"2015","journal-title":"World J Hepatol"},{"issue":"1","key":"10.1016\/j.orcp.2023.11.001_bib18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1001\/archneur.64.1.126","article-title":"Ornithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgery","volume":"64","author":"Hu","year":"2007","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.orcp.2023.11.001_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.psym.2017.07.009","article-title":"Psychiatric manifestations of hyperammonemic encephalopathy following Roux-en-Y gastric bypass","volume":"59","author":"Borreggine","year":"2018","journal-title":"Psychosomatics"},{"issue":"3","key":"10.1016\/j.orcp.2023.11.001_bib20","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.soard.2013.10.020","article-title":"Hyperammonemic encephalopathy complicating bariatric surgery: a case study and review of the literature","volume":"10","author":"Estrella","year":"2014","journal-title":"Surg Obes Relat Dis J Am Soc Bariatr Surg"},{"key":"10.1016\/j.orcp.2023.11.001_bib21","first-page":"9031087","article-title":"Nonfatal hyperammonemic encephalopathy as a late complication of Roux-en-Y gastric bypass","volume":"2019","author":"Salcedo","year":"2019","journal-title":"Case Rep Gastrointest Med"},{"issue":"7","key":"10.1016\/j.orcp.2023.11.001_bib22","article-title":"Bariatric surgery causing hyperammonemia","volume":"11","author":"Krishnan","year":"2019","journal-title":"Cureus"},{"issue":"7","key":"10.1016\/j.orcp.2023.11.001_bib23","doi-asserted-by":"crossref","DOI":"10.14309\/crj.0000000000000119","article-title":"Postbariatric surgery hyperammonemia: a rare cause of encephalopathy","volume":"6","author":"Castineira","year":"2019","journal-title":"ACG Case Rep J"},{"key":"10.1016\/j.orcp.2023.11.001_bib24","first-page":"1138","article-title":"Letter to the Editor Responding to \"Recurrent hyperammonemia during enteral tube feeding for severe protein malnutrition after bariatric surgery\"","volume":"30","year":"2020"},{"issue":"8","key":"10.1016\/j.orcp.2023.11.001_bib25","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1007\/s11695-020-04557-6","article-title":"An effective way to treat hyperammonemic encephalopathy complicated post-distal Roux-en-Y gastric bypass surgery","volume":"30","author":"Sun","year":"2020","journal-title":"Obes Surg"},{"issue":"2","key":"10.1016\/j.orcp.2023.11.001_bib26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11606-007-0473-0","article-title":"Hyperammonemic encephalopathy caused by carnitine deficiency","volume":"23","author":"Limketkai","year":"2008","journal-title":"J Gen Intern Med"},{"issue":"8","key":"10.1016\/j.orcp.2023.11.001_bib27","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1007\/s11695-018-3305-x","article-title":"Fatal hyperammonemic encephalopathy in a pediatric patient after Roux-en-Y gastric bypass","volume":"28","author":"Bonasso","year":"2018","journal-title":"Obes Surg"},{"issue":"6","key":"10.1016\/j.orcp.2023.11.001_bib28","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1007\/s00261-017-1313-2","article-title":"Percutaneous gastric remnant gastrostomy following Roux-en-Y gastric bypass surgery: a single tertiary center's 13-year experience","volume":"43","author":"Shaikh","year":"2018","journal-title":"Abdom Radiol"},{"issue":"25","key":"10.1016\/j.orcp.2023.11.001_bib29","doi-asserted-by":"crossref","first-page":"8288","DOI":"10.3748\/wjg.v20.i25.8288","article-title":"Novel therapy for non-cirrhotic hyperammonemia due to a spontaneous splenorenal shunt","volume":"20","author":"Rogal","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.orcp.2023.11.001_bib30","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.amjmed.2007.08.032","article-title":"Fatal hyperammonemic encephalopathy after gastric bypass surgery","volume":"121","author":"Fenves","year":"2008","journal-title":"Am J Med"},{"issue":"Supplement 1","key":"10.1016\/j.orcp.2023.11.001_bib31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/01.ccm.0000528446.22292.0d","article-title":"Hyperammonemic encephalopathy and new-onset seizures in a roux-en-y and short bowel syndrome patient","volume":"46","author":"Grogg","year":"2018","journal-title":"Crit Care Med"},{"issue":"4 Suppl","key":"10.1016\/j.orcp.2023.11.001_bib32","first-page":"002","article-title":"Unmasked adult-onset urea cycle disorders in the critical care setting","volume":"21","author":"Summar","year":"2005","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.orcp.2023.11.001_bib33","doi-asserted-by":"crossref","first-page":"S220","DOI":"10.14309\/00000434-201310001-00738","article-title":"Hyperammonemic encephalopathy after gastric bypass surgery: 738","volume":"108","author":"Laoye","year":"2013","journal-title":"J Am Coll Gastroenterol | ACG"},{"key":"10.1016\/j.orcp.2023.11.001_bib34","series-title":"Physiology, Urea Cycle","author":"Barmore","year":"2021"},{"key":"10.1016\/j.orcp.2023.11.001_bib35","series-title":"Urea Cycle Disorders","author":"Stone","year":"2021"},{"issue":"1\u20132","key":"10.1016\/j.orcp.2023.11.001_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ymgme.2014.08.001","article-title":"A longitudinal study of urea cycle disorders","volume":"113","author":"Batshaw","year":"2014","journal-title":"Mol Genet Metab"},{"issue":"4","key":"10.1016\/j.orcp.2023.11.001_bib37","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1378\/chest.06-2940","article-title":"Hyperammonemia in the ICU","volume":"132","author":"Clay","year":"2007","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.orcp.2023.11.001_bib38","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1515\/CCLM.2002.112","article-title":"Mechanisms of hyperammonemia","volume":"40","author":"Bachmann","year":"2002","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"10.1016\/j.orcp.2023.11.001_bib39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/clpt.2012.112","article-title":"Ammonia-lowering strategies for the treatment of hepatic encephalopathy","volume":"92","author":"Rose","year":"2012","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.orcp.2023.11.001_bib40","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1080\/10428190701509822","article-title":"Hyperammonemia encephalopathy: an important cause of neurological deterioration following chemotherapy","volume":"48","author":"Nott","year":"2007","journal-title":"Leuk Lymphoma"},{"issue":"8","key":"10.1016\/j.orcp.2023.11.001_bib41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ncpuro0877","article-title":"Urea-splitting urinary tract infection contributing to hyperammonemic encephalopathy","volume":"4","author":"Albersen","year":"2007","journal-title":"Nat Clin Pract Urol"},{"issue":"11","key":"10.1016\/j.orcp.2023.11.001_bib42","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1001\/archinte.1984.04400020208038","article-title":"Hyperammonemic encephalopathy due to essential amino acid hyperalimentation","volume":"144","author":"Grazer","year":"1984","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.orcp.2023.11.001_bib43","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0016-5085(95)90295-3","article-title":"Hyperammonemic coma due to parenteral nutrition in a woman with heterozygous ornithine transcarbamylase deficiency","volume":"109","author":"Felig","year":"1995","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.orcp.2023.11.001_bib44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1046\/j.1528-1157.2002.25001.x","article-title":"Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy","volume":"43","author":"Vossler","year":"2002","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.orcp.2023.11.001_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11910-015-0597-2","article-title":"Neurological complications of bariatric surgery","volume":"15","author":"Goodman","year":"2015","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"7","key":"10.1016\/j.orcp.2023.11.001_bib46","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.jocn.2011.11.006","article-title":"Dry Beriberi and Wernicke's encephalopathy following gastric lap band surgery","volume":"19","author":"Becker","year":"2012","journal-title":"J Clin Neurosc: J Neurosurg Soc Australas"},{"issue":"4","key":"10.1016\/j.orcp.2023.11.001_bib47","first-page":"240","article-title":"Effects of zinc on hepatic ornithine transcarbamylase (OTC) activity","volume":"7","author":"Aquilio","year":"1993","journal-title":"J Trace Elem Electrolytes Health Dis"},{"issue":"3","key":"10.1016\/j.orcp.2023.11.001_bib48","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hep.26611","article-title":"Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy","volume":"59","author":"Rockey","year":"2014","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.orcp.2023.11.001_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5049\/EBP.2011.9.2.45","article-title":"Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism","volume":"9","author":"Han","year":"2011","journal-title":"Electrolyte Blood Press"}],"container-title":["Obesity Research & Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X23001242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X23001242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:31:43Z","timestamp":1761730303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X23001242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1871403X23001242"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2023.11.001","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonhepatic hyperammonemic encephalopathy following bariatric surgery: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Obesity Research & Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.orcp.2023.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}