{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:27:14Z","timestamp":1790011634955,"version":"4.0.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"am","delay-in-days":450,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Research & Clinical Practice"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.orcp.2024.07.001","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T03:39:45Z","timestamp":1720582785000},"page":"301-307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Investigation of setmelanotide, an MC4R agonist, for obesity in individuals with Smith-Magenis syndrome"],"prefix":"10.1016","volume":"18","author":[{"given":"Julia","family":"Lazareva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Sisley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Brady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Elsea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Pomeroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Sprague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Garrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Yanovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.orcp.2024.07.001_bib1","unstructured":"Smith A.C.M., Boyd K.E., Brennan C., et al. Smith-Magenis Syndrome. In: Adam MP, Ardinger HH, Pagon RA, editors. GeneReviews\u00ae. Seattle: University of Washington, Seattle; 2001 [Updated 2019 Jun 20]. p. 1\u201330. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1310\/."},{"issue":"4","key":"10.1016\/j.orcp.2024.07.001_bib2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/ng1126","article-title":"Mutations in RAI1 associated with Smith-Magenis syndrome","volume":"33","author":"Slager","year":"2003","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.orcp.2024.07.001_bib3","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/ajmg.a.62380","article-title":"Possible underreporting of pathogenic variants in RAI1 causing Smith-Magenis syndrome","volume":"185","author":"Boot","year":"2021","journal-title":"Am J Med Genet"},{"issue":"2","key":"10.1016\/j.orcp.2024.07.001_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/genes13020335","article-title":"Smith-Magenis syndrome-clinical review, biological background and related disorders","volume":"13","author":"Rinaldi","year":"2022","journal-title":"Genes"},{"issue":"20","key":"10.1016\/j.orcp.2024.07.001_bib5","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1093\/hmg\/ddq317","article-title":"Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome","volume":"19","author":"Burns","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.orcp.2024.07.001_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.gimo.2024.101857","article-title":"Blind to the perils of pursuing food: behaviors of individuals with smith-magenis syndrome","author":"Elatrash","year":"2024","journal-title":"Genet Med Open"},{"issue":"4","key":"10.1016\/j.orcp.2024.07.001_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i4.20","article-title":"The role of the leptin-melanocortin signalling pathway in the control of food intake","volume":"19","author":"Beckers","year":"2009","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"12","key":"10.1016\/j.orcp.2024.07.001_bib8","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.2337\/db06-0550","article-title":"Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene","volume":"55","author":"Gray","year":"2006","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.orcp.2024.07.001_bib9","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.2337\/db06-0214","article-title":"Heterozygosity for a POMC-null mutation and increased obesity risk in humans","volume":"55","author":"Farooqi","year":"2006","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.orcp.2024.07.001_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41591-018-0015-9","article-title":"MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency","volume":"24","author":"Clement","year":"2018","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.orcp.2024.07.001_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa1512693","article-title":"Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist","volume":"375","author":"Kuhnen","year":"2016","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.orcp.2024.07.001_bib12","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1111\/dom.14133","article-title":"Effect of setmelanotide, a melanocortin-4 receptor agonist, on obesity in Bardet-Biedl syndrome","volume":"22","author":"Haws","year":"2020","journal-title":"Diabetes Obes Metab"},{"issue":"12","key":"10.1016\/j.orcp.2024.07.001_bib13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S2213-8587(22)00277-7","article-title":"Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alstrom syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period","volume":"10","author":"Haqq","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"6","key":"10.1016\/j.orcp.2024.07.001_bib14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/03014460.2020.1808065","article-title":"A method for calculating BMI z-scores and percentiles above the 95(th) percentile of the CDC growth charts","volume":"47","author":"Wei","year":"2020","journal-title":"Ann Hum Biol"},{"issue":"7","key":"10.1016\/j.orcp.2024.07.001_bib15","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nn1073","article-title":"Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor","volume":"6","author":"Xu","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.orcp.2024.07.001_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.semcancer.2023.03.008","article-title":"Excess body weight: Novel insights into its roles in obesity comorbidities","volume":"92","author":"Zhang","year":"2023","journal-title":"Semin Cancer Biol"},{"issue":"9","key":"10.1016\/j.orcp.2024.07.001_bib17","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJMoa0801119","article-title":"Brain-derived neurotrophic factor and obesity in the WAGR syndrome","volume":"359","author":"Han","year":"2008","journal-title":"N Engl J Med"}],"container-title":["Obesity Research & Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X24000826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X24000826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:51:43Z","timestamp":1728399103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X24000826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1871403X24000826"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2024.07.001","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of setmelanotide, an MC4R agonist, for obesity in individuals with Smith-Magenis syndrome","name":"articletitle","label":"Article Title"},{"value":"Obesity Research & Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.orcp.2024.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.","name":"copyright","label":"Copyright"}]}}