{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:50:21Z","timestamp":1791665421108,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Research &amp; Clinical Practice"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.orcp.2026.10.003","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:14:53Z","timestamp":1791580493000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Costs of two-step MASLD screening using ALT and elastography in children with overweight and obesity"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0214-988X","authenticated-orcid":false,"given":"Anne-Sophie R.","family":"Stroes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Muntjewerff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Draijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Chegary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Kreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erim","family":"van Os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joery","family":"Goede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venje","family":"Boonstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Westerbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Bouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Meeike","family":"Kusters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosje","family":"Roelants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Beuers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan G.","family":"Holleboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Benninga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart G.P.","family":"Koot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.orcp.2026.10.003_bib1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12519-024-00814-1","article-title":"Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents: a systematic review and meta-analysis","volume":"20","author":"Lee","year":"2024","journal-title":"World J Pediatr"},{"issue":"10","key":"10.1016\/j.orcp.2026.10.003_bib2","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/apt.12518","article-title":"Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non-alcoholic fatty liver disease","volume":"38","author":"Schwimmer","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.orcp.2026.10.003_bib3","article-title":"Long-term mortality and extrahepatic outcomes in 1096 children with MASLD: a retrospective cohort study","author":"Schwimmer","year":"2025","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.orcp.2026.10.003_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00431-024-05848-1","article-title":"Pediatric MASLD: current understanding and practical approach","volume":"184","author":"Stroes","year":"2024","journal-title":"Eur J Pediatr"},{"issue":"5","key":"10.1016\/j.orcp.2026.10.003_bib5","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.jhep.2021.06.034","article-title":"Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality","volume":"75","author":"Simon","year":"2021","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.orcp.2026.10.003_bib6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cgh.2022.05.028","article-title":"Incidence of type 2 diabetes in children with nonalcoholic fatty liver disease","volume":"21","author":"Newton","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.orcp.2026.10.003_bib7","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.28785","article-title":"The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.orcp.2026.10.003_bib8","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001368","article-title":"AASLD practice statement on the evaluation and management of metabolic dysfunction-associated steatotic liver disease in children","author":"Xanthakos","year":"2025","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.orcp.2026.10.003_bib9","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/jpn3.12156","article-title":"Paediatric steatotic liver disease has unique characteristics: a multisociety statement endorsing the new nomenclature","volume":"78","author":"ESPGHAN","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"10.1016\/j.orcp.2026.10.003_bib10","article-title":"Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity","volume":"151","author":"Hampl","year":"2023","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.orcp.2026.10.003_bib11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/obr.12556","article-title":"Screening for non-alcoholic fatty liver disease in children: do guidelines provide enough guidance?","volume":"18","author":"Koot","year":"2017","journal-title":"Obes Rev"},{"key":"10.1016\/j.orcp.2026.10.003_bib12","series-title":"Principles and practice of screening for disease","author":"Wilson","year":"1968"},{"issue":"2","key":"10.1016\/j.orcp.2026.10.003_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cgh.2025.05.011","article-title":"ALT is an effective screening tool for advanced MASLD in children with obesity and overweight","volume":"24","author":"Stroes","year":"2026","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.orcp.2026.10.003_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.orcp.2025.12.010","article-title":"Children's experience of screening and evaluation for MASLD in overweight and obesity","volume":"20","author":"Stroes","year":"2026","journal-title":"Obes Res Clin Pract"},{"issue":"4","key":"10.1016\/j.orcp.2026.10.003_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16119","article-title":"Pharmaco-economic assessment of screening strategies for high-risk MASLD in primary care","volume":"45","author":"Younossi","year":"2025","journal-title":"Liver Int"},{"issue":"9","key":"10.1016\/j.orcp.2026.10.003_bib16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1001\/archpediatrics.2009.104","article-title":"Classification of body fatness by body mass index-for-age categories among children","volume":"163","author":"Freedman","year":"2009","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.orcp.2026.10.003_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/jpn3.70490","article-title":"European society for pediatric gastroenterology, hepatology and nutrition (ESPGHAN) position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease","author":"Mann","year":"2026","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"10.1016\/j.orcp.2026.10.003_bib18","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1136\/gutjnl-2024-333171","article-title":"British society of gastroenterology guidelines for diagnosis and management of autoimmune hepatitis","volume":"74","author":"Gleeson","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.orcp.2026.10.003_bib19","article-title":"EASL Clinical Practice Guidelines on the management of autoimmune hepatitis","author":"EASL","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.orcp.2026.10.003_bib20","article-title":"EASL-ERN Clinical Practice Guidelines on Wilson's disease","author":"EASL","year":"2025","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.orcp.2026.10.003_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/hep.22376","article-title":"Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis","volume":"48","author":"Nobili","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.orcp.2026.10.003_bib22","article-title":"Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease","author":"Nichols","year":"2025","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.orcp.2026.10.003_bib23","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1053\/j.gastro.2019.01.042","article-title":"Accuracy of fibroscan controlled attenuation parameter and liver stiffness measurement in assessing steatosis and fibrosis in patients with nonalcoholic fatty liver disease","volume":"156","author":"Eddowes","year":"2019","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.orcp.2026.10.003_bib24","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1111\/apa.16502","article-title":"Evaluation of the feasibility of screening for paediatric non-alcoholic fatty liver disease","volume":"111","author":"Draijer","year":"2022","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.orcp.2026.10.003_bib25","first-page":"1","article-title":"Kostenhandleiding voor economische evaluaties in de gezondheidszorg: Methodologie en Referentieprijzen [Costing Manual for Economic Evaluations in","author":"Nederland","year":"2024","journal-title":"Health Methodol Ref Prices] Zorginstituut Ned"},{"key":"10.1016\/j.orcp.2026.10.003_bib26","unstructured":"Consumentenprijzen; prijsindex 2015=100 [Internet]. 2025."},{"issue":"1","key":"10.1016\/j.orcp.2026.10.003_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jval.2021.11.1351","article-title":"Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations","volume":"25","author":"Husereau","year":"2022","journal-title":"Value Health"},{"issue":"7","key":"10.1016\/j.orcp.2026.10.003_bib28","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.2337\/dc19-2003","article-title":"Cost and cost-effectiveness of large-scale screening for type 1 diabetes in Colorado","volume":"43","author":"McQueen","year":"2020","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.orcp.2026.10.003_bib29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2337\/dc21-1648","article-title":"Costs of public health screening of children for presymptomatic type 1 diabetes in Bavaria, Germany","volume":"45","author":"Karl","year":"2022","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.orcp.2026.10.003_bib30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jcf.2018.03.002","article-title":"Strategies for newborn screening for cystic fibrosis: a systematic review of health economic evaluations","volume":"17","author":"Schmidt","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"6","key":"10.1016\/j.orcp.2026.10.003_bib31","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/hep.23910","article-title":"Re-evaluation of the diagnostic criteria for Wilson disease in children with mild liver disease","volume":"52","author":"Nicastro","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.orcp.2026.10.003_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cgh.2006.10.011","article-title":"Clinicopathologic features of the severe form of acute type 1 autoimmune hepatitis","volume":"5","author":"Abe","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.orcp.2026.10.003_bib33","article-title":"Features and outcome of AIH patients without elevation of IgG","volume":"2","author":"Hartl","year":"2020","journal-title":"JHEP Rep"},{"issue":"2","key":"10.1016\/j.orcp.2026.10.003_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MPG.0000000000001482","volume":"64","author":"Vos","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Obesity Research &amp; Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X2600102X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871403X2600102X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:17:10Z","timestamp":1791663430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871403X2600102X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"alternative-id":["S1871403X2600102X"],"URL":"https:\/\/doi.org\/10.1016\/j.orcp.2026.10.003","relation":{},"ISSN":["1871-403X"],"issn-type":[{"value":"1871-403X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Costs of two-step MASLD screening using ALT and elastography in children with overweight and obesity","name":"articletitle","label":"Article Title"},{"value":"Obesity Research & Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.orcp.2026.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.","name":"copyright","label":"Copyright"}]}}