{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:26:31Z","timestamp":1771259191133,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.oret.2016.09.001","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T22:30:16Z","timestamp":1478730616000},"page":"25-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Visual and Morphologic Outcomes in Eyes with Hard Exudate in the Comparison of Age-Related Macular Degeneration Treatments Trials"],"prefix":"10.1016","volume":"1","author":[{"given":"Ebenezer","family":"Daniel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan E.","family":"Grunwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen G.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn J.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia A.","family":"Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Frederick L.","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Shuang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2016.09.001_bib1","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.2337\/diabetes.53.11.2883","article-title":"A\u00a0prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes","volume":"53","author":"Miljanovic","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.oret.2016.09.001_bib2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0161-6420(91)32145-6","article-title":"The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate","volume":"98","author":"Klein","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib3","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1001\/jamaophthalmol.2014.2854","article-title":"Prevalence of and risk factors for diabetic macular edema in the United States","volume":"132","author":"Varma","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2125.1999.00092.x","article-title":"The UK prospective diabetes study (UKPDS): clinical and therapeutic implications for type 2 diabetes","volume":"48","author":"King","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.oret.2016.09.001_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3928\/15428877-20100430-04","article-title":"Atorvastatin for diabetic macular edema in patients with diabetes mellitus and elevated serum cholesterol","volume":"41","author":"Panagiotoglou","year":"2010","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"10.1016\/j.oret.2016.09.001_bib6","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJMoa1102673","article-title":"Ranibizumab and bevacizumab for neovascular age-related macular degeneration","volume":"364","author":"Martin","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.oret.2016.09.001_bib7","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.ophtha.2012.02.013","article-title":"Photographic assessment of baseline fundus morphologic features in the Comparison of Age-Related Macular Degeneration Treatments Trials","volume":"119","author":"Grunwald","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib8","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.ophtha.2012.06.040","article-title":"Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials","volume":"119","author":"DeCroos","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ophtha.2015.10.034","article-title":"Outcomes in eyes with retinal angiomatous proliferation in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT)","volume":"123","author":"Daniel","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib10","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.ophtha.2015.11.030","article-title":"Angiographic cystoid macular edema and outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials","volume":"123","author":"Shah","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib11","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1167\/iovs.09-5064","article-title":"A\u00a0systematic correlation between morphology and functional alterations in diabetic macular edema","volume":"51","author":"De\u00e1k","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2016.09.001_bib12","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archopht.1996.01100140281004","article-title":"Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early Treatment Diabetic Retinopathy Study (ETDRS) Report 22","volume":"114","author":"Chew","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0022-3859.62419","article-title":"Association of systemic risk factors with the severity of retinal hard exudates in a north Indian population with type 2 diabetes","volume":"56","author":"Sachdev","year":"2010","journal-title":"J\u00a0Postgrad Med"},{"key":"10.1016\/j.oret.2016.09.001_bib14","first-page":"251","article-title":"Macular edema and retinal hard exudates in African Americans with type 1 diabetes: the New Jersey 725","volume":"119","author":"Roy","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1900\/RDS.2013.10.121","article-title":"Dyslipidemia and diabetic retinopathy","volume":"10","author":"Chang","year":"2013","journal-title":"Rev Diabet Stud"},{"key":"10.1016\/j.oret.2016.09.001_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1196\/annals.1395.021","article-title":"The importance of serum lipids in exudative diabetic macular edema in type 2 diabetic patients","volume":"1100","author":"U\u00e7gun","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.oret.2016.09.001_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10238-004-0054-z","article-title":"Changes in lipid metabolism in women with age-related macular degeneration","volume":"4","author":"Nowak","year":"2005","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.oret.2016.09.001_bib18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1076\/opep.6.2.125.1558","article-title":"Do age-related macular degeneration and cardiovascular disease share common antecedents?","volume":"6","author":"Snow","year":"1999","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.oret.2016.09.001_bib19","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1167\/iovs.14-16271","article-title":"Diabetes, cardiovascular morbidity, and risk of age-related macular degeneration in a primary care population","volume":"56","author":"Vassilev","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2016.09.001_bib20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5301\/ejo.5000023","article-title":"Patients with neovascular age-related macular degeneration in Spain display a high cardiovascular risk","volume":"22","author":"Olea","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archopht.118.3.351","article-title":"Hypertension, cardiovascular disease, and age-related macular degeneration. Age-Related Macular Degeneration Risk Factors Study Group","volume":"118","author":"Hyman","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib22","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2007.07.031","article-title":"Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization","volume":"115","author":"Hogg","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib23","doi-asserted-by":"crossref","first-page":"e108196","DOI":"10.1371\/journal.pone.0108196","article-title":"Diabetes mellitus and risk of age-related macular degeneration: a systematic review and meta-analysis","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2016.09.001_bib24","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1001\/archopht.126.9.1280","article-title":"Hospitalized cardiovascular diseases in neovascular age-related macular degeneration","volume":"126","author":"Nguyen-Khoa","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib25","doi-asserted-by":"crossref","first-page":"e0143924","DOI":"10.1371\/journal.pone.0143924","article-title":"Effect of high-density lipoprotein metabolic pathway gene variations and risk factors on neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in China","volume":"10","author":"Meng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2016.09.001_bib26","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/archophthalmol.2012.1107","article-title":"Factors associated with changes in visual acuity and central subfield thickness at 1 year after treatment for diabetic macular edema with ranibizumab","volume":"130","author":"Bressler","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib27","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0039-6257(84)90227-3","article-title":"Macular edema. A complication of diabetic retinopathy","volume":"28","author":"Ferris","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.ophtha.2015.02.036","article-title":"Predictors of functional and anatomic outcomes in patients with diabetic macular edema treated with ranibizumab","volume":"122","author":"Sophie","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib29","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1097\/IAE.0000000000000250","article-title":"Distribution of intraretinal exudates in diabetic macular edema during anti-vascular endothelial growth factor therapy observed by spectral domain optical coherence tomography and fundus photography","volume":"34","author":"Pemp","year":"2014","journal-title":"Retina"},{"key":"10.1016\/j.oret.2016.09.001_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ophtha.2014.10.028","article-title":"Effects of intravitreal ranibizumab on retinal hard exudate in diabetic macular edema: findings from the RIDE and RISE phase III clinical trials","volume":"122","author":"Domalpally","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0002-9394(14)71277-2","article-title":"Lipid exudation in age-related macular degeneration","volume":"116","author":"Lozano-Rechy","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib32","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1001\/archopht.122.5.710","article-title":"Morphometric analysis of angiograms of exudative lesions in age-related macular degeneration","volume":"122","author":"Ali","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib33","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archopht.1997.01100160043006","article-title":"Subretinal fibrosis in diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 23","volume":"115","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib34","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/archopht.121.12.1728","article-title":"Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake","volume":"121","author":"Seddon","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1001\/archopht.125.5.671","article-title":"The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS report no. 20","volume":"125","author":"SanGiovanni","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2016.09.001_bib36","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1073\/pnas.0912019107","article-title":"Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)","volume":"107","author":"Neale","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.oret.2016.09.001_bib37","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.ophtha.2010.07.009","article-title":"Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration","volume":"117","author":"Reynolds","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2016.09.001_bib38","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1001\/jamaophthalmol.2014.1752","article-title":"The relationship between hepatic lipase gene variant and advanced age-related macular degeneration: a meta-analysis","volume":"132","author":"Lou","year":"2014","journal-title":"JAMA Ophthalmol"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246865301630029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246865301630029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:23:00Z","timestamp":1762852980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246865301630029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S246865301630029X"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2016.09.001","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visual and Morphologic Outcomes in Eyes with Hard Exudate in the Comparison of Age-Related Macular Degeneration Treatments Trials","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2016.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}