{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:55:23Z","timestamp":1787802923691,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002806","name":"Carl Zeiss Meditec AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.oret.2019.03.001","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T02:04:17Z","timestamp":1553047457000},"page":"580-588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Combined Multimodal Analysis of Peripheral Retinal and Macular Circulation in Diabetic Retinopathy (COPRA Study)"],"prefix":"10.1016","volume":"3","author":[{"given":"Chris","family":"Or","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Despotovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Yasin","family":"Alibhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Moult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia K.","family":"Waheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Chakravarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2019.03.001_bib1","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.oret.2019.03.001_bib2","first-page":"4415","article-title":"Non-rigid registration of fluorescein angiography and optical coherence tomography via scanning laser ophthalmoscope imaging","volume":"2017","author":"Ghasemi Kamasi","year":"2017","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"issue":"1 Pt 2","key":"10.1016\/j.oret.2019.03.001_bib3","first-page":"1","article-title":"Diabetic retinopathy study. Report Number 6. Design, methods, and baseline results. Report Number 7. A modification of the Airlie House classification of diabetic retinopathy","volume":"21","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5 Suppl","key":"10.1016\/j.oret.2019.03.001_bib4","first-page":"786","article-title":"Grading diabetic retinopathy from stereoscopic color fundus photographs\u2014an extension of the modified Airlie House classification. ETDRS report number 10","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.03.001_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4239\/wjd.v4.i6.290","article-title":"Classification of diabetic retinopathy and diabetic macular edema","volume":"4","author":"Wu","year":"2013","journal-title":"World J Diabetes"},{"key":"10.1016\/j.oret.2019.03.001_bib6","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1167\/iovs.12-11103","article-title":"The effects of macular ischemia on visual acuity in diabetic retinopathy","volume":"54","author":"Sim","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.03.001_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00006982-198500510-00002","article-title":"Macular edema following panretinal photocoagulation","volume":"5","author":"McDonald","year":"1985","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.03.001_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/0301-4738.178145","article-title":"Advances in retinal imaging for diabetic retinopathy and diabetic macular edema","volume":"64","author":"Tan","year":"2016","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/IAE.0b013e3182278b64","article-title":"Ultra\u2013wide-field angiography improves the detection and classification of diabetic retinopathy","volume":"32","author":"Wessel","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.03.001_bib10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ophtha.2015.01.008","article-title":"Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years","volume":"122","author":"Silva","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.03.001_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.oret.2019.03.001_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.preteyeres.2017.07.002","article-title":"Optical coherence tomography angiography: a comprehensive review of current methods and clinical applications","volume":"60","author":"Kashani","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.oret.2019.03.001_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","article-title":"Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography","volume":"133","author":"Spaide","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ajo.2014.03.009","article-title":"Patterns of peripheral retinal and central macula ischemia in diabetic retinopathy as evaluated by ultra-widefield fluorescein angiography","volume":"158","author":"Sim","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.oret.2017.05.007","article-title":"Correlation analysis between foveal avascular zone and peripheral ischemic index in diabetic retinopathy: a pilot study","volume":"2","author":"Rabiolo","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2019.03.001_bib16","doi-asserted-by":"crossref","first-page":"42201","DOI":"10.1038\/srep42201","article-title":"Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.oret.2019.03.001_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000442773","article-title":"ZEISS Angioplex\u2122 spectral domain optical coherence tomography angiography: technical aspects","volume":"56","author":"Rosenfeld","year":"2016","journal-title":"Dev Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.oret.2017.09.011","article-title":"Quantifying microvascular changes using OCT angiography in diabetic eyes without clinical evidence of retinopathy","volume":"2","author":"Alibhai","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2019.03.001_bib19","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1001\/jamaophthalmol.2016.4272","article-title":"Visualization of 3 distinct retinal plexuses by projection-resolved optical coherence tomography angiography in diabetic retinopathy","volume":"134","author":"Hwang","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib20","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.survophthal.2017.05.006","article-title":"The application of optical coherence tomography angiography in retinal diseases","volume":"62","author":"Sambhav","year":"2017","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib21","first-page":"46","article-title":"Use of OCTA, FA, and Ultra-widefield imaging in quantifying retinal ischemia: a review","volume":"7","author":"Or","year":"2018","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"10.1016\/j.oret.2019.03.001_bib22","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/IAE.0000000000000859","article-title":"Capillary plexus anomalies in diabetic retinopathy on optical coherence tomography angiography","volume":"35","author":"Couturier","year":"2015","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.03.001_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/bjophthalmol-2016-309424","article-title":"Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography","volume":"101","author":"Soares","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib24","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1364\/OL.41.002330","article-title":"Wide-field optical coherence tomography angiography enabled by two repeated measurements of B-scans","volume":"41","author":"Wang","year":"2016","journal-title":"Opt Lett"},{"key":"10.1016\/j.oret.2019.03.001_bib25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3928\/23258160-20150610-03","article-title":"Visualization of the retinal vasculature using wide-field montage optical coherence tomography angiography","volume":"46","author":"de Carlo","year":"2015","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.oret.2019.03.001_bib26","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.ajo.2015.02.009","article-title":"Quantitative analysis of peripheral vasculitis, ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography","volume":"159","author":"Karampelas","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2147\/OPTH.S133637","article-title":"Ultra-wide-field fluorescein angiography in diabetic retinopathy: a narrative review","volume":"11","author":"Rabiolo","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.oret.2019.03.001_bib28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ajo.2007.11.019","article-title":"Clinically significant macular edema and survival in type 1 and type 2 diabetes","volume":"145","author":"Hirai","year":"2008","journal-title":"Am J Ophthalmol"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653018305803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653018305803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:25:54Z","timestamp":1762853154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653018305803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S2468653018305803"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2019.03.001","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined Multimodal Analysis of Peripheral Retinal and Macular Circulation in Diabetic Retinopathy (COPRA Study)","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2019.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}