{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:01:47Z","timestamp":1787619707222,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008556","name":"Paul MacKall and Evanina Bell MacKall Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015195","name":"Applied Genetic Technologies Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY001583"],"award-info":[{"award-number":["P30 EY001583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY028601"],"award-info":[{"award-number":["R01EY028601"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01EY025477"],"award-info":[{"award-number":["U01EY025477"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017547","name":"Spark Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018132","name":"Pennsylvania Lions Sight Conservation and Eye Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.oret.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T22:56:34Z","timestamp":1557356194000},"page":"888-899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry"],"prefix":"10.1016","volume":"3","author":[{"given":"William S.","family":"Tuten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace K.","family":"Vergilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria J.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas S.","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Brainard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica I.W.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2019.05.002_bib1","series-title":"GeneReviews\u00ae","article-title":"Choroideremia","author":"MacDonald","year":"2003"},{"key":"10.1016\/j.oret.2019.05.002_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/humu.10114","article-title":"Mutational analysis of patients with the diagnosis of choroideremia","volume":"20","author":"McTaggart","year":"2002","journal-title":"Hum Mutat"},{"key":"10.1016\/j.oret.2019.05.002_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/13816810490514333","article-title":"Rab escort protein 1 (REP1) in intracellular traffic: a functional and pathophysiological overview","volume":"25","author":"Preising","year":"2004","journal-title":"Ophthalmic Genetics"},{"key":"10.1016\/j.oret.2019.05.002_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ophtha.2016.10.022","article-title":"Natural history of the central structural abnormalities in choroideremia: a prospective cross-sectional study","volume":"124","author":"Aleman","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.05.002_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/13816810.2011.620056","article-title":"Choroideremia: a review of general findings and pathogenesis","volume":"33","author":"Coussa","year":"2012","journal-title":"Ophthalmic Genetics"},{"key":"10.1016\/j.oret.2019.05.002_bib6","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1167\/iovs.13-13454","article-title":"High-resolution adaptive optics retinal imaging of cellular structure in choroideremia","volume":"55","author":"Morgan","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib7","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1167\/iovs.06-0424","article-title":"Remodeling of the human retina in choroideremia: Rab escort protein 1 (REP-1) mutations","volume":"47","author":"Jacobson","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib8","doi-asserted-by":"crossref","first-page":"OCT377","DOI":"10.1167\/iovs.15-18421","article-title":"Visual function and central retinal structure in choroideremia","volume":"57","author":"Heon","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/13816810.2011.623261","article-title":"Choroideremia: effect of age on visual acuity in patients and female carriers","volume":"33","author":"Coussa","year":"2012","journal-title":"Ophthalmic Genetics"},{"key":"10.1016\/j.oret.2019.05.002_bib10","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1167\/iovs.16-19338","article-title":"Microperimetry as an outcome measure in choroideremia trials: reproducibility and beyond","volume":"57","author":"Dimopoulos","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib11","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1097\/IAE.0000000000001764","article-title":"The natural history of full-field stimulus threshold decline in choroideremia","volume":"38","author":"Dimopoulos","year":"2018","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.05.002_bib12","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(13)62117-0","article-title":"Retinal gene therapy in patients with choroideremia: initial findings from a phase 1\/2 clinical trial","volume":"383","author":"MacLaren","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.oret.2019.05.002_bib13","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1056\/NEJMc1509501","article-title":"Visual acuity after retinal gene therapy for choroideremia","volume":"374","author":"Edwards","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.oret.2019.05.002_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1364\/OE.10.000405","article-title":"Adaptive optics scanning laser ophthalmoscopy","volume":"10","author":"Roorda","year":"2002","journal-title":"Opt Express"},{"key":"10.1016\/j.oret.2019.05.002_bib15","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1167\/iovs.12-10707","article-title":"High-resolution images of retinal structure in patients with choroideremia","volume":"54","author":"Syed","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib16","doi-asserted-by":"crossref","first-page":"e0167526","DOI":"10.1371\/journal.pone.0167526","article-title":"Multimodal imaging of photoreceptor structure in choroideremia","volume":"11","author":"Sun","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.oret.2019.05.002_bib17","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1364\/BOE.2.001757","article-title":"Reflective afocal broadband adaptive optics scanning ophthalmoscope","volume":"2","author":"Dubra","year":"2011","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.oret.2019.05.002_bib18","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1167\/iovs.14-14542","article-title":"In\u00a0vivo imaging of human cone photoreceptor inner segments","volume":"55","author":"Scoles","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1364\/JOSAA.22.000029","article-title":"Chromatic dispersions of the ocular media of human eyes","volume":"22","author":"Atchison","year":"2005","journal-title":"J\u00a0Opt Soc Am A"},{"key":"10.1016\/j.oret.2019.05.002_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF00175988","article-title":"Improvements on Littmann\u2019s method of determining the size of retinal features by fundus photography","volume":"232","author":"Bennett","year":"1994","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.002_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/978-3-642-14366-3_6","article-title":"Registration of 2D images from fast scanning ophthalmic instruments","volume":"6204","author":"Dubra","year":"2010","journal-title":"Lecture Notes in Computer Science"},{"key":"10.1016\/j.oret.2019.05.002_bib22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/OPX.0b013e3182512b98","article-title":"Adaptive optics scanning laser ophthalmoscope-based microperimetry","volume":"89","author":"Tuten","year":"2012","journal-title":"Optometry and Vision Science"},{"key":"10.1016\/j.oret.2019.05.002_bib23","first-page":"6","article-title":"Spatial summation in the human fovea: do normal optical aberrations and fixational eye movements have an effect?","volume":"18","author":"Tuten","year":"2018","journal-title":"J\u00a0Vision"},{"key":"10.1016\/j.oret.2019.05.002_bib24","doi-asserted-by":"crossref","first-page":"13731","DOI":"10.1364\/OE.15.013731","article-title":"Retinally stabilized cone-targeted stimulus delivery","volume":"15","author":"Arathorn","year":"2007","journal-title":"Opt Express"},{"key":"10.1016\/j.oret.2019.05.002_bib25","doi-asserted-by":"crossref","first-page":"17841","DOI":"10.1364\/OE.18.017841","article-title":"Design of an integrated hardware interface for AOSLO image capture and cone-targeted stimulus delivery","volume":"18","author":"Yang","year":"2010","journal-title":"Opt Express"},{"key":"10.1016\/j.oret.2019.05.002_bib26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0042-6989(94)90039-6","article-title":"Efficient and unbiased modifications of the QUEST threshold method: theory, simulations, experimental evaluation and practical implementation","volume":"34","author":"King-Smith","year":"1994","journal-title":"Vision Research"},{"key":"10.1016\/j.oret.2019.05.002_bib27","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3389\/fpsyg.2018.01250","article-title":"Applying the model-comparison approach to test specific research hypotheses in psychophysical research using the Palamedes toolbox","volume":"9","author":"Prins","year":"2018","journal-title":"Frontiers in Psychology"},{"key":"10.1016\/j.oret.2019.05.002_bib28","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1097\/OPX.0b013e31822b3746","article-title":"Comparing the Nidek MP-1 and Humphrey field analyzer in normal subjects","volume":"88","author":"Acton","year":"2011","journal-title":"Optometry and Vision Science"},{"key":"10.1016\/j.oret.2019.05.002_bib29","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1364\/BOE.3.002066","article-title":"Measurement and correction of transverse chromatic offsets for multi-wavelength retinal microscopy in the living eye","volume":"3","author":"Harmening","year":"2012","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.oret.2019.05.002_bib30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1364\/OL.33.000156","article-title":"Efficient subpixel image registration algorithms","volume":"33","author":"Guizar-Sicairos","year":"2008","journal-title":"Opt Lett"},{"key":"10.1016\/j.oret.2019.05.002_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/OPX.0000000000001031","article-title":"SD-OCT and adaptive optics imaging of outer retinal tubulation","volume":"94","author":"King","year":"2017","journal-title":"Optometry and Vision Science"},{"key":"10.1016\/j.oret.2019.05.002_bib32","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/IAE.0000000000000471","article-title":"Outer retinal tubulation in advanced age-related macular degeneration: optical coherence tomographic findings correspond to histology","volume":"35","author":"Schaal","year":"2015","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.05.002_bib33","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1167\/iovs.17-22486","article-title":"Characterizing the natural history of visual function in choroideremia using microperimetry and multimodal retinal imaging","volume":"58","author":"Jolly","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib34","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1167\/iovs.14-15977","article-title":"Test-retest repeatability of microperimetry at the border of deep scotomas","volume":"56","author":"Wu","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib35","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1097\/IAE.0b013e318296b12f","article-title":"Outer retinal tubulation in degenerative retinal disorders","volume":"33","author":"Goldberg","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.05.002_bib36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jamaophthalmol.2015.126","article-title":"Clinicopathological correlation of outer retinal tubulation in age-related macular degeneration","volume":"133","author":"Litts","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.002_bib37","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.ophtha.2017.03.043","article-title":"The evolution of outer retinal tubulation, a neurodegeneration and gliosis prominent in macular diseases","volume":"124","author":"Dolz-Marco","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.05.002_bib38","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/IAE.0000000000001265","article-title":"Exploring photoreceptor reflectivity through multimodal imaging of outer retinal tubulation in advanced age-related macular degeneration","volume":"37","author":"Litts","year":"2017","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.05.002_bib39","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/archopht.125.8.1107","article-title":"Clinical and functional findings in choroideremia due to complete deletion of the CHM gene","volume":"125","author":"Mura","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.002_bib40","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1167\/iovs.05-1195","article-title":"Retinal microscotomas revealed with adaptive-optics microflashes","volume":"47","author":"Makous","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib41","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1167\/iovs.14-15576","article-title":"Adaptive optics microperimetry and OCT images show preserved function and recovery of cone visibility in macular telangiectasia type 2 retinal lesions","volume":"56","author":"Wang","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.002_bib42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ajoc.2017.04.001","article-title":"Dysflective cones: visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis","volume":"7","author":"Tu","year":"2017","journal-title":"Am J Ophthalmol Case Reports"},{"key":"10.1016\/j.oret.2019.05.002_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1364\/BOE.9.000157","article-title":"Ultra-high contrast retinal display system for single photoreceptor psychophysics","volume":"9","author":"Domdei","year":"2018","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.oret.2019.05.002_bib44","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1364\/BOE.8.005098","article-title":"Non-invasive assessment of human cone photoreceptor function","volume":"8","author":"Cooper","year":"2017","journal-title":"Biomed Opt Express"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019300144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019300144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:25:55Z","timestamp":1762853155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653019300144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S2468653019300144"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2019.05.002","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2019.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}