{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:36:36Z","timestamp":1786995396418,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.oret.2019.05.014","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T11:32:05Z","timestamp":1567596725000},"page":"713-715","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Seven Points That Explain the Lack of Effect from Reperfusion Therapy in Central Retinal Artery Occlusion"],"prefix":"10.1016","volume":"3","author":[{"given":"Mirza","family":"Jusufovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elsais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Kerty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2019.05.014_bib1","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.ophtha.2015.07.018","article-title":"Risk and risk periods for stroke and acute myocardial infarction in patients with central retinal artery occlusion","volume":"122","author":"Park","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.05.014_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ajo.2019.01.009","article-title":"Acute vascular ischemic events in patients with central retinal artery occlusion in the United States: a nationwide study 2003\u20132014","volume":"200","author":"Mir","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.014_bib3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fneur.2018.00076","article-title":"Intra-arterial thrombolysis for acute central retinal artery occlusion: a systematic review and meta-analysis","volume":"9","author":"Page","year":"2018","journal-title":"Front Neurol"},{"key":"10.1016\/j.oret.2019.05.014_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/NRL.0000000000000129","article-title":"Is intravenous thrombolysis safe and effective in central retinal artery occlusion? A critically appraised topic","volume":"22","author":"Dumitrascu","year":"2017","journal-title":"Neurologist"},{"key":"10.1016\/j.oret.2019.05.014_bib5","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(14)60584-5","article-title":"Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials","volume":"384","author":"Emberson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.oret.2019.05.014_bib6","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ophtha.2010.03.061","article-title":"Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial","volume":"117","author":"Schumacher","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.05.014_bib7","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.ophtha.2018.03.054","article-title":"Management of acute retinal ischemia: follow the guidelines!","volume":"125","author":"Biousse","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.05.014_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-4835(73)90185-1","article-title":"Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues","volume":"15","author":"Alm","year":"1973","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.oret.2019.05.014_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/bjo.68.1.10","article-title":"Comparison of retinal and cerebral vasculature in trypsin digest preparations","volume":"68","author":"Cogan","year":"1984","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.014_bib10","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1007\/s11095-005-6335-8","article-title":"Feasibility of tissue plasminogen activator formulated for pulmonary delivery","volume":"22","author":"Dunn","year":"2005","journal-title":"Pharm Res"},{"key":"10.1016\/j.oret.2019.05.014_bib11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4103\/1673-5374.179033","article-title":"Acute development of collateral circulation and therapeutic prospects in ischemic stroke","volume":"11","author":"Iwasawa","year":"2016","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.oret.2019.05.014_bib12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/jon.12387","article-title":"The role of topographic collaterals in predicting functional outcome after thrombolysis in anterior circulation ischemic stroke","volume":"27","author":"Tan","year":"2017","journal-title":"J\u00a0Neuroimaging"},{"key":"10.1016\/j.oret.2019.05.014_bib13","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1212\/01.wnl.0000244492.99737.a8","article-title":"Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT","volume":"67","author":"Kim","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.oret.2019.05.014_bib14","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S0161-6420(82)34626-6","article-title":"Ophthalmologic findings in 70 patients with evidence of retinal embolism","volume":"89","author":"Arruga","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.05.014_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000047689","article-title":"Retinal ischemia and embolism. Etiologies and outcomes based on a prospective study","volume":"12","author":"Babikian","year":"2001","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.oret.2019.05.014_bib16","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1161\/01.STR.0000029827.93497.97","article-title":"Comparison of risk factors in patients with transient and prolonged eye and brain ischemic syndromes","volume":"33","author":"Mead","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.oret.2019.05.014_bib17","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/bjo.64.12.896","article-title":"Experimental occlusion of the central artery of the retina. I. Ophthalmoscopic and fluorescein fundus angiographic studies","volume":"64","author":"Hayreh","year":"1980","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.014_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12886-018-0768-4","article-title":"Central retinal artery occlusion\u2014rethinking retinal survival time","volume":"18","author":"Tobalem","year":"2018","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.oret.2019.05.014_bib19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.06.001","article-title":"Evidence for an enduring ischaemic penumbra following central retinal artery occlusion, with implications for fibrinolytic therapy","volume":"49","author":"McLeod","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.oret.2019.05.014_bib20","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1167\/iovs.13-12952","article-title":"Efficacy and safety of intra-arterial thrombolysis in central retinal artery occlusion","volume":"54","author":"Ahn","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.05.014_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198114","article-title":"Intravenous thrombolysis in acute central retinal artery occlusion\u2014a prospective interventional case series","volume":"13","author":"Schultheiss","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2019.05.014_bib22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ajo.2005.03.038","article-title":"Central retinal artery occlusion: visual outcome","volume":"140","author":"Hayreh","year":"2005","journal-title":"Am J Ophthalmol"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246865301930226X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246865301930226X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:26:10Z","timestamp":1762853170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246865301930226X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S246865301930226X"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2019.05.014","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seven Points That Explain the Lack of Effect from Reperfusion Therapy in Central Retinal Artery Occlusion","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2019.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}