{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:24:16Z","timestamp":1783693456056,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.oret.2019.09.018","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T11:37:24Z","timestamp":1570621044000},"page":"300-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Maculopathy in Patients with Monoclonal Gammopathy of Undetermined Significance"],"prefix":"10.1016","volume":"4","author":[{"given":"Stephen J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant M.","family":"Comer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2019.09.018_bib1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.oret.2019.09.018_bib2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4065\/mcp.2010.0520","article-title":"Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence","volume":"85","author":"Rajkumar","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.oret.2019.09.018_bib3","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.mayocp.2012.06.014","article-title":"Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition","volume":"87","author":"Therneau","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.oret.2019.09.018_bib4","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/ICO.0b013e318199f73b","article-title":"Crystal-storing histiocytosis and crystalline keratopathy caused by monoclonal gammopathy of undetermined significance","volume":"28","author":"de Alba Campomanes","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.oret.2019.09.018_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/bjh.12047","article-title":"Crystalline keratopathy associated with monoclonal gammopathy of undetermined significance","volume":"159","author":"Nagendran","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.oret.2019.09.018_bib6","doi-asserted-by":"crossref","first-page":"e0026","DOI":"10.5041\/RMMJ.10211","article-title":"Unusual manifestations of monoclonal gammopathy: I. Ocular disease","volume":"6","author":"Balderman","year":"2015","journal-title":"Rambam Maimonides Med J"},{"key":"10.1016\/j.oret.2019.09.018_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0039-6257(81)90065-5","article-title":"Ocular manifestations of multiple myeloma, Waldenstrom\u2019s macroglobulinemia and benign monoclonal gammopathy","volume":"26","author":"Orellana","year":"1981","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0161-6420(00)00118-4","article-title":"Unusual immunogammopathy maculopathy","volume":"107","author":"Ho","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.09.018_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ajo.2012.09.018","article-title":"Serous macular detachment in Waldenstrom macroglobulinemia: a report of four cases","volume":"155","author":"Baker","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3928\/1542-8877-20000501-19","article-title":"Occult retinal pigment epithelial detachment in hyperviscosity syndrome","volume":"31","author":"Ogata","year":"2000","journal-title":"Ophthalmic Surg Lasers"},{"key":"10.1016\/j.oret.2019.09.018_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00006982-199616060-00001","article-title":"Paraproteinemias associated with serous detachments of the retinal pigment epithelium and neurosensory retina","volume":"16","author":"Cohen","year":"1996","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.09.018_bib12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/bjophthalmol-2012-302851","article-title":"Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease","volume":"97","author":"Spielberg","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0420.1995.tb00019.x","article-title":"Multiple myeloma presenting with bilateral exudative macular detachments","volume":"73","author":"Brody","year":"1995","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.oret.2019.09.018_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/ICB.0b013e31828ef0dc","article-title":"Immunogammopathy maculopathy associated with Waldenstrom macroglobulinemia is refractory to conventional interventions for macular edema","volume":"7","author":"Besirli","year":"2013","journal-title":"Retin Cases Brief Rep"},{"key":"10.1016\/j.oret.2019.09.018_bib15","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ajo.2013.11.020","article-title":"Immunogammopathies and acquired vitelliform detachments: a report of four cases","volume":"157","author":"Rusu","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib16","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.ophtha.2014.04.007","article-title":"Paraproteinemic maculopathy","volume":"121","author":"Mansour","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.09.018_bib17","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1016\/j.jcjo.2013.07.018","article-title":"Monoclonal gammopathy of undetermined significance maculopathy","volume":"48","author":"Saffra","year":"2013","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib18","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1056\/NEJMoa1200710","article-title":"MYD88 L265P somatic mutation in Waldenstrom\u2019s macroglobulinemia","volume":"367","author":"Treon","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.oret.2019.09.018_bib19","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1182\/blood-2008-12-195008","article-title":"A\u00a0monoclonal gammopathy precedes multiple myeloma in most patients","volume":"113","author":"Weiss","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.oret.2019.09.018_bib20","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1182\/blood-2008-12-194241","article-title":"Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study","volume":"113","author":"Landgren","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.oret.2019.09.018_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00006982-199004000-00005","article-title":"Retinal vasculopathy associated with systemic light chain deposition disease","volume":"10","author":"Enzenauer","year":"1990","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.09.018_bib22","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/1097-0142(19871101)60:9<2267::AID-CNCR2820600927>3.0.CO;2-4","article-title":"Light chain disease associated with the hyperviscosity syndrome","volume":"60","author":"Khan","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.oret.2019.09.018_bib23","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1056\/NEJMcp052790","article-title":"Clinical practice. Monoclonal gammopathy of undetermined significance","volume":"355","author":"Blade","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.oret.2019.09.018_bib24","first-page":"179","article-title":"IgM paraprotein in the subretinal fluid of a patient with recurrent retinal detachment and Waldenstrom\u2019s macroglobulinaemia","volume":"42","author":"Berta","year":"1985","journal-title":"Acta Med Hung"},{"key":"10.1016\/j.oret.2019.09.018_bib25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/archopht.1980.01020030737020","article-title":"Immunofluorescent studies of the eye in Waldenstrom\u2019s macroglobulinemia","volume":"98","author":"Freidman","year":"1980","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00227726","article-title":"Immunoelectron microscopic localization of monoclonal IgM antibodies in gammopathy associated with peripheral demyelinative neuropathy","volume":"85","author":"Lach","year":"1993","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.oret.2019.09.018_bib27","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.4049\/jimmunol.179.5.2999","article-title":"NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences","volume":"179","author":"Liu","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.oret.2019.09.018_bib28","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/bjo.2010.187930","article-title":"The neonatal Fc receptor is expressed by human retinal pigment epithelial cells and is downregulated by tumour necrosis factor-alpha","volume":"95","author":"van Bilsen","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib29","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/leu.2013.62","article-title":"MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenstrom\u2019s macroglobulinemia","volume":"27","author":"Jimenez","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.oret.2019.09.018_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/112067219500500202","article-title":"Ocular pathology in light chain deposition disease","volume":"5","author":"Daicker","year":"1995","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.oret.2019.09.018_bib31","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1182\/blood-2012-07-445304","article-title":"Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant","volume":"120","author":"Leung","year":"2012","journal-title":"Blood"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019305780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019305780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:27:08Z","timestamp":1762853228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653019305780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2468653019305780"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2019.09.018","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maculopathy in Patients with Monoclonal Gammopathy of Undetermined Significance","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2019.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}