{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:45:45Z","timestamp":1790484345863,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005111","name":"BMC Software","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015195","name":"Applied Genetic Technologies Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.oret.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T12:03:58Z","timestamp":1574165038000},"page":"384-393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Safety and Efficacy of Subretinally Administered Palucorcel for Geographic Atrophy of Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"4","author":[{"given":"Jeffrey S.","family":"Heier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-608X","authenticated-orcid":false,"given":"Allen C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Riemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Kitchens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Slakter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-9863","authenticated-orcid":false,"given":"Yannek I.","family":"Leiderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-1860","authenticated-orcid":false,"given":"Rand","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-4469","authenticated-orcid":false,"given":"Sheila B.","family":"Hickson-Curran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Baldassarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2019.11.011_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nri3459","article-title":"Immunology of age-related macular degeneration","volume":"13","author":"Ambati","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.oret.2019.11.011_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ophtha.2013.11.023","article-title":"Geographic atrophy: clinical features and potential therapeutic approaches","volume":"121","author":"Holz","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.11.011_bib3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1242\/dmm.017236","article-title":"Cellular models and therapies for age-related macular degeneration","volume":"8","author":"Forest","year":"2015","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.oret.2019.11.011_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12967-018-1434-6","article-title":"RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells","volume":"16","author":"Inana","year":"2018","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.oret.2019.11.011_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126636","article-title":"Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration","volume":"10","author":"Grassmann","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2019.11.011_bib6","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1177\/0963689717721227","article-title":"Perspectives of stem cell-based therapy for age-related retinal degenerative diseases","volume":"26","author":"Holan","year":"2017","journal-title":"Cell Transplant"},{"key":"10.1016\/j.oret.2019.11.011_bib7","first-page":"3843","article-title":"Stem cell-based therapies for age-related macular degeneration: current status and prospects","volume":"7","author":"Mu","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.oret.2019.11.011_bib8","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1634\/stemcells.2006-0308erratum","article-title":"Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease","volume":"25","author":"Lund","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.oret.2019.11.011_bib9","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1523\/JNEUROSCI.1532-17.2018","article-title":"Subretinal human umbilical tissue-derived cell transplantation preserves retinal synaptic connectivity and attenuates Muller glial reactivity","volume":"38","author":"Koh","year":"2018","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.oret.2019.11.011_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/stem.2239","article-title":"Human umbilical tissue-derived cells rescue retinal pigment epithelium dysfunction in retinal degeneration","volume":"34","author":"Cao","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.oret.2019.11.011_bib11","doi-asserted-by":"crossref","first-page":"15649","DOI":"10.1523\/JNEUROSCI.1364-15.2015","article-title":"Human umbilical tissue-derived cells promote synapse formation and neurite outgrowth via thrombospondin family proteins","volume":"35","author":"Koh","year":"2015","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.oret.2019.11.011_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ajo.2017.04.006","article-title":"Experience with a subretinal cell-based therapy in patients with geographic atrophy secondary to age-related macular degeneration","volume":"179","author":"Ho","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.11.011_bib13","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.2147\/OPTH.S140218","article-title":"Epiretinal membrane in a subject after transvitreal delivery of palucorcel (CNTO 2476)","volume":"11","author":"Spencer","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.oret.2019.11.011_bib14","series-title":"Cellular Therapies for Retinal Disease: A Strategic Approach","first-page":"95","article-title":"Subretinal delivery of cells via the suprachoroidal space: Janssen trial","author":"Baldassarre","year":"2017"},{"key":"10.1016\/j.oret.2019.11.011_bib15","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ophtha.2014.12.037","article-title":"Changes in lens opacities on the age-related eye disease study grading scale predict progression to cataract surgery and vision loss: Age-Related Eye Disease Study report no. 34","volume":"122","author":"Indaram","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.11.011_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1167\/iovs.17-22233","article-title":"A\u00a0subretinal cell delivery method via suprachoroidal access in minipigs: safety and surgical outcomes","volume":"59","author":"de Smet","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2019.11.011_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ophtha.2010.08.018","article-title":"Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography","volume":"118","author":"Yehoshua","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.11.011_bib18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.ajo.2005.07.040","article-title":"Long-term follow-up of fixation patterns in eyes with central scotomas from geographic atrophy that is associated with age-related macular degeneration","volume":"140","author":"Sunness","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.11.011_bib19","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.2147\/OPTH.S144985","article-title":"Intraocular pressure 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension","volume":"11","author":"Fang","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.oret.2019.11.011_bib20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ajo.2004.09.046","article-title":"Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation","volume":"139","author":"Holekamp","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.11.011_bib21","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.2147\/OPTH.S68661","article-title":"Cataract formation following vitreoretinal procedures","volume":"8","author":"Feng","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.oret.2019.11.011_bib22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0140-6736(12)60028-2","article-title":"Embryonic stem cell trials for macular degeneration: a preliminary report","volume":"379","author":"Schwartz","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.oret.2019.11.011_bib23","doi-asserted-by":"crossref","first-page":"ORSFc1","DOI":"10.1167\/iovs.15-18681","article-title":"Subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium for the treatment of macular degeneration: an assessment at 4\u00a0years","volume":"57","author":"Schwartz","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019306359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019306359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:27:36Z","timestamp":1762853256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653019306359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S2468653019306359"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2019.11.011","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and Efficacy of Subretinally Administered Palucorcel for Geographic Atrophy of Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}