{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:46:25Z","timestamp":1788954385778,"version":"build-2803163510"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.oret.2019.12.004","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T13:10:09Z","timestamp":1576156209000},"page":"498-503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Macular Hole\u2013Related Retinal Detachment in Children with Knobloch Syndrome"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-1989","authenticated-orcid":false,"given":"Sulaiman M.","family":"Alsulaiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulelah A.","family":"Al-Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Alakeely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-1234","authenticated-orcid":false,"given":"Hassan","family":"Aldhibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonore","family":"Engelbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola G.","family":"Ghazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2019.12.004_bib1","first-page":"181","article-title":"Retinal detachment and encephalocele","volume":"8","author":"Knobloch","year":"1971","journal-title":"J\u00a0Pediat Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib2","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1093\/hmg\/9.13.2051","article-title":"Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome)","volume":"9","author":"Sertie","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.oret.2019.12.004_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/humu.10284","article-title":"Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin","volume":"23","author":"Menzel","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1016\/j.oret.2019.12.004_bib4","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/bjophthalmol-2011-301396","article-title":"The distinct ophthalmic phenotype of Knobloch syndrome in children","volume":"96","author":"Khan","year":"2012","journal-title":"Br J Ophthalmol.Br J Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib5","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/jamaophthalmol.2016.1073","article-title":"Molecular and clinical findings in patients with Knobloch syndrome","volume":"134","author":"Hull","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s00417-006-0281-y","article-title":"Collagen XVIII\/endostatin shows a ubiquitous distribution in human ocular tissues and endostatin-containing fragments accumulate in ocular fluid samples","volume":"245","author":"Maatta","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib7","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/emboj\/21.7.1535","article-title":"Lack of collagen XVIII\/endostatin results in eye abnormalities","volume":"21","author":"Fukai","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.oret.2019.12.004_bib8","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.3928\/23258160-20190806-13","article-title":"Optical coherence tomography in Knobloch syndrome","volume":"50","author":"Thau","year":"2019","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.oret.2019.12.004_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/13816810.2016.1164197","article-title":"Biometry, optical coherence tomography, and further clinical observations in Knobloch syndrome","volume":"38","author":"AlBakri","year":"2017","journal-title":"Ophthalmic Genet"},{"key":"10.1016\/j.oret.2019.12.004_bib10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12886-017-0615-z","article-title":"Knobloch syndrome associated with Polymicrogyria and early onset of retinal detachment: two case reports","volume":"17","author":"White","year":"2017","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00006982-199111030-00002","article-title":"Causative factors of retinal detachment in macular holes","volume":"11","author":"Morita","year":"1991","journal-title":"Retina"},{"key":"10.1016\/j.oret.2019.12.004_bib12","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ophtha.2003.08.026","article-title":"Retinal detachment associated with macular hole in high myopia: using the vitreous anatomy to optimize the surgical approach","volume":"111","author":"Ripandelli","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.12.004_bib13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0002-9394(03)00186-7","article-title":"Surgical management of retinal myopic detachment associated with macular hole: anatomic and functional status of the macula","volume":"136","author":"Ichiba","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0002-9394(98)00180-9","article-title":"Complete epiretinal membrane separation in highly myopic eyes with retinal detachment resulting from a macular hole","volume":"126","author":"Oshima","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9394(00)00728-5","article-title":"Treatment of retinal detachment resulting from myopic macular hole with internal limiting membrane removal","volume":"131","author":"Kadonosono","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ajo.2013.02.014","article-title":"Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia","volume":"156","author":"Kuriyama","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2019.12.004_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ophtha.2019.01.027","article-title":"Autologous retinal transplant for refractory macular holes: Multicenter International Collaborative Study Group","volume":"126","author":"Grewal","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2019.12.004_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/01.iae.0000256660.48993.9e","article-title":"Anatomical and visual outcomes after episcleral macular buckling compared with those after pars plana vitrectomy for retinal detachment caused by macular hole in highly myopic eyes","volume":"27","author":"Ando","year":"2007","journal-title":"Retina"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019306682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653019306682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:27:10Z","timestamp":1762853230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653019306682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S2468653019306682"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2019.12.004","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macular Hole\u2013Related Retinal Detachment in Children with Knobloch Syndrome","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2019.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}