{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:41:54Z","timestamp":1788327714227,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.oret.2020.02.015","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T12:02:34Z","timestamp":1583323354000},"page":"630-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of Systemic Chemotherapy and Delayed Enucleation on Survival of Children with Advanced Intraocular Retinoblastoma"],"prefix":"10.1016","volume":"4","author":[{"given":"Junyang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao Xun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Solarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-1671","authenticated-orcid":false,"given":"Yizhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-122X","authenticated-orcid":false,"given":"Chengyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Gallie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2020.02.015_bib1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1136\/bjo.2008.150292","article-title":"The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death","volume":"93","author":"Kivela","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.ophtha.2003.10.023","article-title":"Incidence of retinoblastoma from 1958 to 1998 in Northern Europe: advantages of birth cohort analysis","volume":"111","author":"Seregard","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ohc.2004.11.003","article-title":"Intraocular retinoblastoma: the case for a new group classification","volume":"18","author":"Murphree","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"key":"10.1016\/j.oret.2020.02.015_bib4","series-title":"AJCC Cancer Staging Manual","first-page":"819","article-title":"Retinoblastoma","author":"Mallipatna","year":"2017"},{"key":"10.1016\/j.oret.2020.02.015_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1200\/JCO.2010.32.5332","article-title":"Pre-enucleation chemotherapy for eyes severely affected by retinoblastoma masks risk of tumor extension and increases death from metastasis","volume":"29","author":"Zhao","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.oret.2020.02.015_bib6","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.ophtha.2006.03.039","article-title":"Metastatic retinoblastoma clinical features, treatment, and prognosis","volume":"113","author":"Gunduz","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib7","doi-asserted-by":"crossref","first-page":"15021","DOI":"10.1038\/nrdp.2015.21","article-title":"Retinoblastoma","volume":"1","author":"Dimaras","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.oret.2020.02.015_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ohc.2004.11.002","article-title":"Chemotherapy for retinoblastoma","volume":"18","author":"Chan","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"issue":"12","key":"10.1016\/j.oret.2020.02.015_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26696","article-title":"Long-term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era","volume":"64","author":"Berry","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.oret.2020.02.015_bib10","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1136\/bjophthalmol-2011-301016","article-title":"Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track","volume":"96","author":"Munier","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib11","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/bjophthalmol-2011-301450","article-title":"Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications","volume":"96","author":"Munier","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib12","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/bjophthalmol-2016-309298","volume":"101","author":"Munier","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib13","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.ophtha.2014.01.026","article-title":"Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma","volume":"121","author":"Shields","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamaophthalmol.2016.0244","article-title":"Intra-arterial chemotherapy for retinoblastoma: a systematic review","volume":"134","author":"Yousef","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1001\/archophthalmol.2011.130","article-title":"Periocular topotecan for intraocular retinoblastoma","volume":"129","author":"Mallipatna","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ophtha.2017.10.015","article-title":"Pars plana vitrectomy and endoresection of refractory intraocular retinoblastoma","volume":"125","author":"Zhao","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib17","series-title":"AJCC Cancer Staging Manual","first-page":"561","article-title":"Retinoblastoma","author":"Finger","year":"2010"},{"key":"10.1016\/j.oret.2020.02.015_bib18","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1200\/JCO.18.00141","article-title":"Delayed enucleation with neoadjuvant chemotherapy in advanced intraocular unilateral retinoblastoma: AHOPCA II, a prospective, multi-institutional protocol in Central America","volume":"37","author":"Luna-Fineman","year":"2019","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.oret.2020.02.015_bib19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/pbc.23307","article-title":"Retinoblastoma in Central America: report from the Central American Association of Pediatric Hematology Oncology (AHOPCA)","volume":"58","author":"Luna-Fineman","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.oret.2020.02.015_bib20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MPH.0b013e3181923cc5","article-title":"Some clinical findings at presentation can predict high-risk pathology features in unilateral retinoblastoma","volume":"31","author":"Chantada","year":"2009","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.oret.2020.02.015_bib21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/pbc.23239","article-title":"Clinical predictors of high risk histopathology in retinoblastoma","volume":"58","author":"Kashyap","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.oret.2020.02.015_bib22","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.ophtha.2015.01.018","article-title":"Clinical features predictive of high-risk retinoblastoma in 403 Asian Indian patients: a case-control study","volume":"122","author":"Kaliki","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib23","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ophtha.2019.04.003","article-title":"Clinical predictors at diagnosis of low risk histopathology in unilateral advanced retinoblastoma","volume":"126","author":"Kletke","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/pbc.24303","article-title":"Long-term outcomes of Group D eyes in bilateral retinoblastoma patients treated with chemoreduction and low-dose IMRT salvage","volume":"60","author":"Berry","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.oret.2020.02.015_bib25","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1097\/MPH.0000000000000141","article-title":"Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation","volume":"36","author":"Sullivan","year":"2014","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.oret.2020.02.015_bib26","first-page":"41","article-title":"Evaluation of chemoprophylaxis in patients with unilateral retinoblastoma with high-risk features on histopathologic examination","volume":"119","author":"Uusitalo","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib27","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1200\/JCO.2012.42.3962","article-title":"Results of a multicenter prospective study on the postoperative treatment of unilateral retinoblastoma after primary enucleation","volume":"31","author":"Aerts","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.oret.2020.02.015_bib28","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1001\/archopht.120.7.923","article-title":"Postenucleation adjuvant therapy in high-risk retinoblastoma","volume":"120","author":"Honavar","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib29","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1001\/archophthalmol.2011.289","article-title":"Postenucleation adjuvant chemotherapy with vincristine, etoposide, and carboplatin for the treatment of high-risk retinoblastoma","volume":"129","author":"Kaliki","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib30","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archophthalmol.2012.567","article-title":"Outcome of children with retinoblastoma and isolated choroidal invasion","volume":"130","author":"Bosaleh","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2020.02.015_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cancergen.2016.06.001","article-title":"Molecular analysis distinguishes metastatic disease from second cancers in patients with retinoblastoma","volume":"209","author":"Racher","year":"2016","journal-title":"Cancer Genet"},{"key":"10.1016\/j.oret.2020.02.015_bib32","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1200\/JCO.18.01808","article-title":"Study of unilateral retinoblastoma with and without histopathologic high-risk features and the role of adjuvant chemotherapy: a Children's Oncology Group Study","volume":"37","author":"Chevez-Barrios","year":"2019","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.oret.2020.02.015_bib33","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.ophtha.2006.06.018","article-title":"The International Classification of Retinoblastoma predicts chemoreduction success","volume":"113","author":"Shields","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.02.015_bib34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/13816810802452168","article-title":"Published international classification of retinoblastoma (ICRB) definitions contain inconsistencies--an analysis of impact","volume":"30","author":"Novetsky","year":"2009","journal-title":"Ophthalmic Genet"},{"key":"10.1016\/j.oret.2020.02.015_bib35","first-page":"S1","article-title":"National Retinoblastoma Strategy Canadian Guidelines for Care\/Strat\u00e9gie th\u00e9rapeutique du r\u00e9tinoblastome guide clinique canadien","volume":"44","year":"2009","journal-title":"Can J Ophthalmol"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653020300798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653020300798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:27:35Z","timestamp":1762853255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653020300798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S2468653020300798"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2020.02.015","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Systemic Chemotherapy and Delayed Enucleation on Survival of Children with Advanced Intraocular Retinoblastoma","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2020.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}]}}