{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:33:07Z","timestamp":1791513187204,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.oret.2020.10.007","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T04:20:07Z","timestamp":1602822007000},"page":"687-695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Risk Factors for Endogenous Endophthalmitis in Hospitalized Patients with Candida Fungemia"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-2798","authenticated-orcid":false,"given":"Aditya","family":"Uppuluri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Zarbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-5226","authenticated-orcid":false,"given":"Greg","family":"Budoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelakshi","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2020.10.007_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/CMR.00113-16","article-title":"Bacterial and fungal endophthalmitis","volume":"30","author":"Durand","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.oret.2020.10.007_bib2","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1016\/j.ijid.2012.12.014","article-title":"Do all candidemic patients need an ophthalmic examination?","volume":"17","author":"Vinikoor","year":"2013","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.oret.2020.10.007_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ajo.2014.11.032","article-title":"Risk factors predictive of endogenous endophthalmitis among hospitalized patients with hematogenous infections in the United States","volume":"159","author":"Vaziri","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2020.10.007_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/596757","article-title":"Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America","volume":"48","author":"Pappas","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.oret.2020.10.007_bib5","series-title":"Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS). Healthcare Cost and Utilization Project (HCUP)","year":"2011"},{"key":"10.1016\/j.oret.2020.10.007_bib6","series-title":"Healthcare Cost and Utilization Project National Inpatient Sample (NIS). Healthcare Cost and Utilization Project (HCUP)","year":"2012"},{"key":"10.1016\/j.oret.2020.10.007_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129360","article-title":"A\u00a0cost analysis of hospitalizations for infections related to injection drug use at a county safety-net hospital in Miami, Florida","volume":"10","author":"Tookes","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2020.10.007_bib8","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1097\/IAE.0000000000000919","article-title":"Prospective trial of endogenous fungal endophthalmitis and chorioretinitis rates, clinical course, and outcomes in patients with fungemia","volume":"36","author":"Paulus","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.oret.2020.10.007_bib9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/00365540410020965","article-title":"Endogenous endophthalmitis: a 13-year review at a tertiary hospital in South Australia","volume":"37","author":"Leibovitch","year":"2005","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.oret.2020.10.007_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ajo.2011.06.020","article-title":"Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes","volume":"153","author":"Lingappan","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2020.10.007_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/eye.2010.145","article-title":"Endogenous endophthalmitis: 10-year experience at a tertiary referral centre","volume":"25","author":"Connell","year":"2011","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.oret.2020.10.007_bib12","first-page":"14, 1-17","article-title":"Endogenous endophthalmitis: a 9-year retrospective study at a tertiary referral hospital in Malaysia","volume":"8","author":"Muda","year":"2018","journal-title":"J\u00a0Ophthal Inflamm Infect"},{"key":"10.1016\/j.oret.2020.10.007_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1469-0691.12118","article-title":"Endophthalmitis","volume":"19","author":"Durand","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.oret.2020.10.007_bib14","first-page":"252","article-title":"Fungal endocarditis","volume":"31","author":"Yuan","year":"2016","journal-title":"Braz J Cardiovasc Surg"},{"key":"10.1016\/j.oret.2020.10.007_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/09273940903494717","article-title":"Endogenous endophthalmitis: a 10-year review of culture-positive cases in Northern China","volume":"18","author":"Zhang","year":"2010","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.oret.2020.10.007_bib16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/IAE.0000000000001204","article-title":"Infectious keratitis-associated endophthalmitis: a 14-year study","volume":"37","author":"Malihi","year":"2017","journal-title":"Retina"},{"key":"10.1016\/j.oret.2020.10.007_bib17","first-page":"50","article-title":"Immune dysfunction in cirrhosis","volume":"5","author":"Noor","year":"2017","journal-title":"J\u00a0Clin Transl Hepatol"},{"issue":"Suppl 6","key":"10.1016\/j.oret.2020.10.007_bib18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.5301\/EJO.2010.6049","article-title":"Blood-retinal barrier","volume":"21","author":"Cunha-Vaz","year":"2011","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.oret.2020.10.007_bib19","article-title":"Treating endogenous endophthalmitis","volume":"6","author":"Relhan","year":"2014","journal-title":"Rev Ophthalmol. October"},{"key":"10.1016\/j.oret.2020.10.007_bib20","first-page":"S30","article-title":"Systemic fungal infections in renal disease","volume":"51","author":"Gandhi","year":"2005","journal-title":"J\u00a0Postgrad Med"},{"key":"10.1016\/j.oret.2020.10.007_bib21","first-page":"262","article-title":"Endogenous endophthalmitis: has the opioid crisis impacted the rates and severity of intravenous drug-related cases?","volume":"2","author":"Russell","year":"2018","journal-title":"J\u00a0Vitreoretin Dis"},{"key":"10.1016\/j.oret.2020.10.007_bib22","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1097\/IAE.0000000000000084","article-title":"Endogenous endophthalmitis associated with intravenous drug abuse","volume":"34","author":"Patel","year":"2014","journal-title":"Retina"},{"key":"10.1016\/j.oret.2020.10.007_bib23","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1097\/IAE.0b013e3181dd6db6","article-title":"Endogenous endophthalmitis associated with intravenous drug abuse: seven-year experience at a tertiary referral center","volume":"30","author":"Connell","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.oret.2020.10.007_bib24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3201\/eid2404.171807","article-title":"Reemergence of intravenous drug use as risk factor for candidemia, Massachusetts, USA","volume":"24","author":"Poowanawittayakom","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.oret.2020.10.007_bib25","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1136\/bmj.292.6528.1106-a","article-title":"Source of infection in candida endophthalmitis in drug addicts","volume":"292","author":"Shankland","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.oret.2020.10.007_bib26","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0360-3016(85)90114-2","article-title":"Long term effects on the immune system following local radiation therapy for breast cancer. I. Cellular composition of the peripheral blood lymphocyte population","volume":"11","author":"Rotstein","year":"1985","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.oret.2020.10.007_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.oret.2020.10.007_bib28","first-page":"725","article-title":"Culture-proven endogenous endophthalmitis: clinical features and visual acuity outcomes","volume":"137","author":"Schiedler","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2020.10.007_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222356","article-title":"Risk factors and outcomes of patients with ocular involvement of candidemia","volume":"14","author":"Son","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2020.10.007_bib30","first-page":"101","article-title":"Intravenous catheter-associated candidemia due to Candida membranaefaciens: the first Iranian case","volume":"10","author":"Aghili","year":"2015","journal-title":"J\u00a0Tehran Heart Cent"},{"key":"10.1016\/j.oret.2020.10.007_bib31","first-page":"255-256","article-title":"Endogenous endophthalmitis as a complication of sepsis related to a tunneled haemodialysis catheter","volume":"32","author":"Cabana-Carcasi","year":"2012","journal-title":"Nefrologia"},{"key":"10.1016\/j.oret.2020.10.007_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/0886022X.2011.623557","article-title":"Endophthalmitis: a rare but devastating metastatic bacterial complication of hemodialysis catheter-related sepsis","volume":"34","author":"De Lima","year":"2012","journal-title":"Renal Failure"},{"key":"10.1016\/j.oret.2020.10.007_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1136\/pmj.77.904.119","article-title":"Candida endophthalmitis: an unusual complication of prolonged intravenous access","volume":"77","author":"Vose","year":"2001","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.oret.2020.10.007_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s15010-018-1163-z","article-title":"Prevalence of, and risk factors for, hematogenous fungal endophthalmitis in patients with\u00a0candida bloodstream infections","volume":"46","author":"Kato","year":"2018","journal-title":"Infection"},{"key":"10.1016\/j.oret.2020.10.007_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.oret.2019.06.004","article-title":"Bacterial endogenous endophthalmitis in bacteremic inpatients","volume":"3","author":"Budoff","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2020.10.007_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/cid\/cir355","article-title":"Ocular manifestations of candidemia","volume":"53","author":"Oude Lashof","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.oret.2020.10.007_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216956","article-title":"The incidence of endophthalmitis or macular involvement and the necessity of a routine ophthalmic examination in patients with candidemia","volume":"14","author":"Ueda","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2020.10.007_bib38","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/S0924-8579(08)70006-2","article-title":"Epidemiology of candidemia in intensive care units","volume":"32","author":"Bouza","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.oret.2020.10.007_bib39","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1128\/JCM.00670-15","article-title":"Overdiagnosis of urinary tract infection and underdiagnosis of sexually transmitted infection in adult women presenting to an emergency department","volume":"53","author":"Tomas","year":"2015","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.oret.2020.10.007_bib40","unstructured":"Center for Substance Abuse Treatment. Substance abuse among older adults. Rockville, MD: Substance Abuse and Mental Health Services Administration; 1998. Treatment Improvement Protocol (TIP) Series, no.\u00a026."}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653020304127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653020304127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:29:09Z","timestamp":1762853349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653020304127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S2468653020304127"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2020.10.007","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Factors for Endogenous Endophthalmitis in Hospitalized Patients with Candida Fungemia","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2020.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}