{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:22:59Z","timestamp":1792581779939,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.oret.2020.12.016","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T10:50:52Z","timestamp":1608979852000},"page":"991-998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spectral Domain OCT Predictors of Visual Acuity in the Study of COmparative Treatments for REtinal Vein Occlusion 2: SCORE 2 Report 15"],"prefix":"10.1016","volume":"5","author":[{"given":"Tyler","family":"Etheridge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Blodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-6821","authenticated-orcid":false,"given":"Neal","family":"Oden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Van Veldhuisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid U.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Ip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Mititelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9619","authenticated-orcid":false,"given":"Amitha","family":"Domalpally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2020.12.016_bib1","first-page":"133","article-title":"The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study","volume":"98","author":"Klein","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.oret.2020.12.016_bib2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1001\/archopht.1996.01100140443012","article-title":"Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study","volume":"114","author":"Mitchell","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib3","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/jth.12982","article-title":"Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study","volume":"13","author":"Ponto","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.oret.2020.12.016_bib4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.ophtha.2010.01.060","article-title":"Natural history of central retinal vein occlusion: an evidence-based systematic review","volume":"117","author":"McIntosh","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib5","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.ophtha.2010.01.058","article-title":"Natural history of branch retinal vein occlusion: an evidence-based systematic review","volume":"117","author":"Rogers","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib6","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ophtha.2010.02.022","article-title":"Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study","volume":"117","author":"Brown","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib7","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ophtha.2010.02.021","article-title":"Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study","volume":"117","author":"Campochiaro","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.ophtha.2012.01.042","article-title":"Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: six-month results of the phase 3 COPERNICUS study","volume":"119","author":"Boyer","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/bjophthalmol-2012-301504","article-title":"VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6-month results of the phase III GALILEO study","volume":"97","author":"Holz","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib10","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1001\/jama.2017.4568","article-title":"Effect of bevacizumab vs aflibercept on visual acuity among patients with macular edema due to central retinal vein occlusion: the SCORE2 Randomized Clinical Trial","volume":"317","author":"Scott","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.oret.2020.12.016_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ophtha.2008.10.017","article-title":"SCORE Study report 1: baseline associations between central retinal thickness and visual acuity in patients with retinal vein occlusion","volume":"116","author":"Scott","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1001\/jamaophthalmol.2017.1141","article-title":"Baseline factors associated with 6-month visual acuity and retinal thickness outcomes in patients with macular edema secondary to central retinal vein occlusion or hemiretinal vein occlusion: SCORE2 Study Report 4","volume":"135","author":"Scott","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajo.2016.08.026","article-title":"Baseline choroidal thickness as a predictor for treatment outcomes in central retinal vein occlusion","volume":"171","author":"Rayess","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib14","first-page":"605","article-title":"Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion","volume":"10","author":"Mo","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib15","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1167\/iovs.18-24153","article-title":"Increased inner retinal layer reflectivity in eyes with acute CRVO correlates with worse visual outcomes at 12 months","volume":"59","author":"Mehta","year":"2018","journal-title":"Invest Ophthalmol Vis Sci. 07"},{"key":"10.1016\/j.oret.2020.12.016_bib16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/IAE.0000000000001579","article-title":"Ranibizumab for retinal vein occlusion: predictive factors and long-term outcomes in real-life data","volume":"38","author":"Chatziralli","year":"2018","journal-title":"Retina"},{"key":"10.1016\/j.oret.2020.12.016_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajo.2017.08.005","article-title":"Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with macular edema secondary to vein occlusion","volume":"182","author":"Mimouni","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib18","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.oret.2018.04.019","article-title":"Association of disorganization of retinal inner layers with ischemic index and visual acuity in central retinal vein occlusion","volume":"2","author":"Berry","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2020.12.016_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/jamaophthalmol.2018.4484","article-title":"Association of disorganization of retinal inner layers with visual acuity response to anti-vascular endothelial growth factor therapy for macular edema secondary to retinal vein occlusion","volume":"137","author":"Babiuch","year":"2019","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib20","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.oret.2017.11.009","article-title":"Ellipsoid zone mapping parameters in retinal venous occlusive disease with associated macular edema","volume":"2","author":"Banaee","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2020.12.016_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.oret.2018.07.008","article-title":"Disorganization of retinal inner layers and ellipsoid zone disruption predict visual outcomes in central retinal vein occlusion","volume":"3","author":"Chan","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2020.12.016_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.oret.2019.08.009","article-title":"Spectral-domain OCT predictors of visual outcomes after ranibizumab treatment for macular edema resulting from retinal vein occlusion","volume":"4","author":"Yiu","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2020.12.016_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ophtha.2016.09.038","article-title":"SCORE2 Report 2: Study Design and Baseline Characteristics","volume":"124","author":"Scott","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2020.12.016_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082922","article-title":"Development of a semi-automatic segmentation method for retinal OCT images tested in patients with diabetic macular edema","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.oret.2020.12.016_bib25","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1001\/jamaophthalmol.2014.2350","article-title":"Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema","volume":"132","author":"Sun","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib26","first-page":"309","article-title":"Disorganization of retinal inner layers in retinal vein occlusions: new insights from anti-VEGF treatment","volume":"3","author":"Nguyen","year":"2019","journal-title":"J\u00a0Vitreoretin Dis"},{"key":"10.1016\/j.oret.2020.12.016_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000490809","article-title":"Disorganization of the retinal inner layers after anti-VEGF treatment for macular edema due to branch retinal vein occlusion","volume":"240","author":"Nakano","year":"2018","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.oret.2020.12.016_bib28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/jamaophthalmol.2018.4516","article-title":"Disorganization of retinal inner layers and the importance of setting boundaries","volume":"137","author":"Schmidt-Erfurth","year":"2019","journal-title":"JAMA Ophthalmol"},{"issue":"7","key":"10.1016\/j.oret.2020.12.016_bib29","article-title":"Reproducibility of disorganization of the retinal inner layers (DRIL) grading across spectral domain optical coherence tomography (SDOCT) model and scan types in eyes with diabetic macular edema (DME)","volume":"56","author":"Abdulaal","year":"2015","journal-title":"A Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2020.12.016_bib30","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1097\/IAE.0000000000001410","article-title":"Capillary nonperfusion and photoreceptor loss in branch retinal vein occlusion: spatial correlation and morphologic characteristics","volume":"37","author":"Kanakis","year":"2017","journal-title":"Retina"},{"key":"10.1016\/j.oret.2020.12.016_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-018-1012-y","article-title":"Baseline characteristics associated with early visual acuity gains after ranibizumab treatment for retinal vein occlusion","volume":"19","author":"Lloyd Clark","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.oret.2020.12.016_bib32","article-title":"Ellipsoid zone status and its association with visual acuity in eyes with macular edema in the Study of COmparative Treatments for REtinal Vein Occlusion 2 (SCORE 2)","volume":"60","author":"Papudesu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653020305030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653020305030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:30:23Z","timestamp":1762853423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653020305030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2468653020305030"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2020.12.016","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spectral Domain OCT Predictors of Visual Acuity in the Study of COmparative Treatments for REtinal Vein Occlusion 2: SCORE 2 Report 15","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2020.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}