{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:33:20Z","timestamp":1790253200551,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.oret.2022.09.007","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T02:14:54Z","timestamp":1665022494000},"page":"253-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["OCT Risk Factors for Development of Atrophy in Eyes with Intermediate Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-6700","authenticated-orcid":false,"given":"Kazutaka","family":"Hirabayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wakatsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-5729","authenticated-orcid":false,"given":"Kenneth M.","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-5091","authenticated-orcid":false,"given":"Charles C.","family":"Wykoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-8834","authenticated-orcid":false,"given":"Srinivas R.","family":"Sadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2022.09.007_bib1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1001\/archopht.121.11.1621","article-title":"Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11","volume":"121","author":"Bressler","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.preteyeres.2017.12.002","article-title":"Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors","volume":"65","author":"Mehta","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.oret.2022.09.007_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40259-021-00481-y","article-title":"Investigational agents in development for the treatment of geographic atrophy secondary to age-related macular degeneration","volume":"35","author":"Yu","year":"2021","journal-title":"BioDrugs"},{"key":"10.1016\/j.oret.2022.09.007_bib4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of atrophy report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib5","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00417-017-3693-y","article-title":"Proposal of a simple optical coherence tomography-based scoring system for progression of age-related macular degeneration","volume":"255","author":"Lei","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib6","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.ophtha.2019.05.016","article-title":"OCT risk factors for development of late age-related macular degeneration in the fellow eyes of patients enrolled in the HARBOR study","volume":"126","author":"Nassisi","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib7","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/IAE.0000000000002263","article-title":"Incidence of late age-related macular degeneration in eyes with reticular pseudodrusen","volume":"39","author":"Kong","year":"2019","journal-title":"Retina"},{"key":"10.1016\/j.oret.2022.09.007_bib8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/eye.2016.207","article-title":"Clinical features and long-term progression of reticular pseudodrusen in age-related macular degeneration: findings from a multicenter cohort","volume":"31","author":"Gil","year":"2017","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.oret.2022.09.007_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.oret.2020.06.026","article-title":"Predicting progression of age-related macular degeneration using OCT and fundus photography","volume":"5","author":"Wu","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2022.09.007_bib10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8","volume":"119","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.oret.2020.02.016","article-title":"Nonexudative macular neovascularization - a systematic review of prevalence, natural history, and recent insights from OCT angiography","volume":"4","author":"Laiginhas","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2022.09.007_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.9.8.8","article-title":"Recognizing atrophy and mixed-type neovascularization in age-related macular degeneration via clinicopathologic correlation","volume":"9","author":"Chen","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.oret.2022.09.007_bib13","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.ophtha.2020.01.040","article-title":"Nonexudative macular neovascularization supporting outer retina in age-related macular degeneration: a clinicopathologic correlation","volume":"127","author":"Chen","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.ajo.2015.08.001","article-title":"Correlation of type 1 neovascularization associated with acquired vitelliform lesion in the setting of age-related macular degeneration","volume":"160","author":"Curcio","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.oret.2018.10.012","article-title":"Predictive value of the OCT double-layer sign for identifying subclinical neovascularization in age-related macular degeneration","volume":"3","author":"Shi","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2022.09.007_bib16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ophtha.2019.11.007","article-title":"Structural OCT signs suggestive of subclinical nonexudative macular neovascularization in eyes with large drusen","volume":"127","author":"Narita","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1167\/iovs.11-8188","article-title":"Automated characterization of pigment epithelial detachment by optical coherence tomography","volume":"53","author":"Lee","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.09.007_bib18","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1038\/s41433-020-01293-0","article-title":"Reproducibility of qualitative assessment of drusen volume in eyes with age related macular degeneration","volume":"35","author":"Corvi","year":"2021","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.oret.2022.09.007_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ophtha.2019.11.004","article-title":"Consensus nomenclature for reporting neovascular age-related macular degeneration data: consensus on neovascular age-related macular degeneration nomenclature study group","volume":"127","author":"Spaide","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib20","first-page":"BIO211","article-title":"Activated retinal pigment epithelium, an optical coherence tomography biomarker for progression in age-related macular degeneration","volume":"58","author":"Curcio","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.09.007_bib21","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1167\/iovs.18-24143","article-title":"Quantity of intraretinal hyperreflective foci in patients with intermediate age-related macular degeneration correlates with 1-year progression","volume":"59","author":"Nassisi","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.09.007_bib22","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.ajo.2014.01.018","article-title":"Macular choroidal thickness and volume of eyes with reticular pseudodrusen using swept-source optical coherence tomography","volume":"157","author":"Ueda-Arakawa","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ajo.2016.10.005","article-title":"Choriocapillaris nonperfusion is associated with poor visual acuity in eyes with reticular pseudodrusen","volume":"174","author":"Nesper","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/tvst.9.10.12","article-title":"Plasma biomarkers of reticular pseudodrusen and the risk of progression to advanced age-related macular degeneration","volume":"9","author":"Lynch","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.oret.2022.09.007_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ajo.2022.03.007","article-title":"Reticular pseudodrusen on the risk of progression in intermediate age-related macular degeneration","volume":"239","author":"Wu","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib26","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1167\/iovs.19-26589","article-title":"The fate and prognostic implications of hyperreflective crystalline deposits in nonneovascular age-related macular degeneration","volume":"60","author":"Fragiotta","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.09.007_bib27","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/j.ophtha.2016.08.047","article-title":"Optical coherence tomography reflective drusen substructures predict progression to geographic atrophy in age-related macular degeneration","volume":"123","author":"Veerappan","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib28","doi-asserted-by":"crossref","first-page":"eaat4544","DOI":"10.1126\/scitranslmed.aat4544","article-title":"Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration","volume":"10","author":"Tan","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.oret.2022.09.007_bib29","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ophtha.2016.01.044","article-title":"Optical coherence tomography angiography of asymptomatic neovascularization in intermediate age-related macular degeneration","volume":"123","author":"Roisman","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib30","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.oret.2021.11.004","article-title":"Hyporeflective cores within drusen: association with progression of age-related macular degeneration and impact on visual sensitivity","volume":"6","author":"Goh","year":"2022","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2022.09.007_bib31","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/bjophthalmol-2020-317326","article-title":"Non-neovascular age-related macular degeneration with subretinal fluid","volume":"105","author":"Hilely","year":"2021","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/bjophthalmol-2016-308422","article-title":"Drusen volume development over time and its relevance to the course of age-related macular degeneration","volume":"101","author":"Schlanitz","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib33","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1167\/iovs.16-19816","article-title":"Associations between retinal pigment epithelium and drusen volume changes during the lifecycle of large drusenoid pigment epithelial detachments","volume":"57","author":"Balaratnasingam","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.09.007_bib34","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.ophtha.2011.05.008","article-title":"Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography","volume":"118","author":"Yehoshua","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.61.13.19","article-title":"Measuring the contributions of basal laminar deposit and Bruch\u2019s membrane in age-related macular degeneration","volume":"61","author":"Sura","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.09.007_bib36","article-title":"Characterisation of the vascular anterior surface of type 1 macular neovascularisation after anti-VEGF therapy","author":"Corvi","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib37","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00417-020-04638-3","article-title":"Investigation of the therapeutic mechanism of subthreshold micropulse laser irradiation in retina","volume":"258","author":"Hirabayashi","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.oret.2022.09.007_bib38","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ophtha.2018.09.015","article-title":"Subthreshold nanosecond laser intervention in age-related macular degeneration: the LEAD randomized controlled clinical trial","volume":"126","author":"Guymer","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.09.007_bib39","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.2147\/OPTH.S268322","article-title":"Slowed progression of age-related geographic atrophy following subthreshold laser","volume":"14","author":"Luttrull","year":"2020","journal-title":"Clin Ophthalmol"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653022004869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653022004869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:31:49Z","timestamp":1762853509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653022004869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2468653022004869"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2022.09.007","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OCT Risk Factors for Development of Atrophy in Eyes with Intermediate Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2022.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}