{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:18:46Z","timestamp":1792844326795,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.oret.2022.12.007","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:28:39Z","timestamp":1671539319000},"page":"420-430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"7","author":[{"given":"Marlene","family":"Sa\u00dfmannshausen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Behning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Weinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Goerdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Terheyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrus","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Poor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Finger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Pfau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schmitz-Valckenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-6700","authenticated-orcid":false,"given":"Sarah","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Altay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Atia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bandello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Behning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Belmouhand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Binns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.F.","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"B\u00f6ttger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bouchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Brazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Carapezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Carlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Charil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"Crabb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cunha-Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dahlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"de Sisternes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Dunbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Finger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gutfleisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.G.","family":"Holz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Hoyng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kr\u00e4tzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"K\u00fchlewein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.T.E.","family":"Lechanteur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.F.O.","family":"Luhmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"L\u00fcning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Martinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Montesano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Mulyukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Paques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parravano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Penas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Peto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pfau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Poor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Priglinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.S.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sa\u00dfmannshausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schmitz-Valckenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Schrinner-Fenske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Siedlecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Skelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Souied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Staurenghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"St\u00f6hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"Terheyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tufail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Varano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Vieweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wintergerst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2022.12.007_bib1","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.oret.2022.12.007_bib2","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0140-6736(12)60282-7","article-title":"Age-related macular degeneration","volume":"379","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.oret.2022.12.007_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.oret.2022.12.007_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101017","article-title":"Reticular pseudodrusen: a critical phenotype in age-related macular degeneration","volume":"88","author":"Wu","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.oret.2022.12.007_bib5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/IAE.0000000000000503","article-title":"Refractile drusen: clinical imaging and candidate histology","volume":"35","author":"Suzuki","year":"2015","journal-title":"Retina"},{"key":"10.1016\/j.oret.2022.12.007_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ajo.2016.09.004","article-title":"A\u00a0perspective on the nature and frequency of pigment epithelial detachments","volume":"172","author":"Tan","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2022.12.007_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.63.2.32","article-title":"Spatial dissociation of subretinal drusenoid deposits and impaired scotopic and mesopic sensitivity in AMD","volume":"63","author":"Zhang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib8","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1097\/IAE.0b013e31829c3765","article-title":"Outer retinal atrophy after regression of subretinal drusenoid deposits as a newly recognized form of late age-related macular degeneration","volume":"33","author":"Spaide","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.oret.2022.12.007_bib9","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1167\/iovs.14-16221","article-title":"In\u00a0vivo quantification of retinal changes associated with drusen in age-related macular degeneration","volume":"56","author":"Rogala","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib10","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.ophtha.2012.10.018","article-title":"Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci","volume":"120","author":"Christenbury","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1186\/s13063-020-04595-6","article-title":"Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration developing novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention-MACUSTAR","volume":"21","author":"Terheyden","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.oret.2022.12.007_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000491402","article-title":"MACUSTAR: development and clinical validation of functional, structural, and patient-reported endpoints in intermediate age-related macular degeneration","volume":"241","author":"Finger","year":"2019","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.oret.2022.12.007_bib13","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/tvst.11.3.27","article-title":"Intersession repeatability of structural biomarkers in early and intermediate age-related macular degeneration: a MACUSTAR study report","volume":"11","author":"Sa\u00dfmannshausen","year":"2022","journal-title":"Trans Vis Sci Technol"},{"key":"10.1016\/j.oret.2022.12.007_bib15","doi-asserted-by":"crossref","first-page":"AMD1","DOI":"10.1167\/iovs.17-23315","article-title":"Multimodal imaging patterns for development of central atrophy secondary to age-related macular degeneration","volume":"59","author":"Thiele","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.oret.2020.12.009","article-title":"Imaging features associated with progression to geographic atrophy in age-related macular degeneration: classification of atrophy\u00a0meeting report 5","volume":"5","author":"Jaffe","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.oret.2022.12.007_bib17","first-page":"BIO211","article-title":"Activated retinal pigment epithelium, an optical coherence tomography biomarker for progression in age-related macular degeneration","volume":"58","author":"Curcio","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ajo.2016.09.008","article-title":"Clinical characteristics, choroidal neovascularization, and predictors of visual outcomes in acquired vitelliform lesions","volume":"172","author":"Balaratnasingam","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2022.12.007_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/IAE.0b013e3181f04974","article-title":"Pathologic insights from integrated imaging of reticular pseudodrusen in age-related macular degeneration","volume":"31","author":"Querques","year":"2011","journal-title":"Retina"},{"key":"10.1016\/j.oret.2022.12.007_bib20","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/IAE.0b013e3181ee5ce8","article-title":"Drusen characterization with multimodal imaging","volume":"30","author":"Spaide","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.oret.2022.12.007_bib21","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.ophtha.2010.01.027","article-title":"Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration","volume":"117","author":"Zweifel","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of atrophy report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib23","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ophtha.2019.09.035","article-title":"Incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration: classification of atrophy meeting report 4","volume":"127","author":"Guymer","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ophtha.2019.11.007","article-title":"Structural OCT signs suggestive of subclinical nonexudative macular neovascularization in eyes with large drusen","volume":"127","author":"Narita","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib25","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.ophtha.2015.01.029","article-title":"Spectral-domain optical coherence tomography angiography of choroidal neovascularization","volume":"122","author":"de Carlo","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ophtha.2015.09.016","article-title":"Drusen volume and retinal pigment epithelium abnormal thinning volume predict 2-year progression of age-related macular degeneration","volume":"123","author":"Folgar","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ophtha.2013.07.013","article-title":"Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography","volume":"121","author":"Farsiu","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib28","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1167\/iovs.11-7457","article-title":"Semiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degeneration","volume":"52","author":"Schmitz-Valckenberg","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ophtha.2018.09.015","article-title":"Subthreshold nanosecond laser intervention in age-related macular degeneration: the LEAD randomized controlled clinical trial","volume":"126","author":"Guymer","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib30","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1167\/iovs.12-9813","article-title":"Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD","volume":"53","author":"Folgar","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib31","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.ophtha.2012.05.027","article-title":"The age-related eye disease study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)","volume":"119","author":"Chew","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib32","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ophtha.2010.08.010","article-title":"Documentation of intraretinal retinal pigment epithelium migration via high-speed ultrahigh-resolution optical coherence tomography","volume":"118","author":"Ho","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib33","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.ophtha.2019.07.022","article-title":"Prevalence, risk, and genetic association of reticular pseudodrusen in age-related macular degeneration: age-related eye disease study 2 report 21","volume":"126","author":"Domalpally","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib34","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1167\/iovs.15-16657","article-title":"Foveal sparing of reticular drusen in eyes with early and intermediate age-related macular degeneration","volume":"56","author":"Steinberg","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib35","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.ophtha.2012.12.007","article-title":"Reticular pseudodrusen","volume":"120","author":"Querques","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib36","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/bjophthalmol-2014-306535","article-title":"Reticular drusen in eyes with high-risk characteristics for progression to late-stage age-related macular degeneration","volume":"99","author":"Steinberg","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2022.12.007_bib37","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1001\/jamaophthalmol.2020.1376","article-title":"Characterization of drusen and hyperreflective foci as biomarkers for disease progression in age-related macular degeneration using artificial intelligence in optical coherence tomography","volume":"138","author":"Waldstein","year":"2020","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2022.12.007_bib38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.62.2.26","article-title":"Topographic distribution and progression of soft drusen volume in age-related macular degeneration implicate neurobiology of fovea","volume":"62","author":"Pollreisz","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2022.12.007_bib39","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.ophtha.2014.06.034","article-title":"Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration","volume":"121","author":"Wu","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2022.12.007_bib40","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1007\/s00417-021-05147-7","article-title":"Drusen ooze: predictor for progression of dry age-related macular degeneration","volume":"259","author":"Jhingan","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653022006091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653022006091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:31:39Z","timestamp":1762853499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653022006091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2468653022006091"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2022.12.007","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2022.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}]}}