{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:48Z","timestamp":1791229488839,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Retina"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.oret.2025.05.012","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T19:23:24Z","timestamp":1747164204000},"page":"1098-1105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Recurrence of Macular Edema in Branch Retinal Vein Occlusion"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6407-375X","authenticated-orcid":false,"given":"Anna","family":"Cullhed Farrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-5904","authenticated-orcid":false,"given":"Manuel","family":"Casselholm de Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1004-3672","authenticated-orcid":false,"given":"Charlotte","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-3138","authenticated-orcid":false,"given":"David","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.oret.2025.05.012_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/02713680701851902","article-title":"Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities","volume":"33","author":"Rehak","year":"2008","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.oret.2025.05.012_bib2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/01.iae.0000242842.14624.e7","article-title":"Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration","volume":"26","author":"Ferrara","year":"2006","journal-title":"Retina"},{"key":"10.1016\/j.oret.2025.05.012_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.eye.6702498","article-title":"Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion","volume":"22","author":"Noma","year":"2008","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.oret.2025.05.012_bib5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ophtha.2014.08.031","article-title":"Intravitreal aflibercept for macular edema following branch retinal vein occlusion: the 24-week results of the VIBRANT study","volume":"122","author":"Campochiaro","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2025.05.012_bib6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ophtha.2015.09.035","article-title":"Intravitreal aflibercept for macular edema following branch retinal vein occlusion: 52-week results of the VIBRANT study","volume":"123","author":"Clark","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2025.05.012_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10456-011-9249-6","article-title":"Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab","volume":"15","author":"Papadopoulos","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.oret.2025.05.012_bib8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/bjo.2007.134874","article-title":"Predicted biological activity of intravitreal VEGF Trap","volume":"92","author":"Stewart","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241613004","article-title":"Twenty years of anti-vascular endothelial growth factor therapeutics in neovascular age-related macular degeneration treatment","volume":"24","author":"Moon","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.oret.2025.05.012_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10384-016-0476-7","article-title":"Comparison between ranibizumab and aflibercept for macular edema associated with central retinal vein occlusion","volume":"61","author":"Saishin","year":"2017","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib11","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/IAE.0000000000002171","article-title":"Injection frequency of aflibercept versus ranibizumab in a treat-and-extend regimen for central retinal vein occlusion: a randomized clinical trial","volume":"39","author":"Casselholm de Salles","year":"2019","journal-title":"Retina"},{"key":"10.1016\/j.oret.2025.05.012_bib12","article-title":"Evaluation of choroidal thickness using optical coherent tomography: a review","volume":"8","author":"Xie","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.oret.2025.05.012_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207435","article-title":"Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-a novel OCT based imaging biomarker","volume":"13","author":"Gupta","year":"2018","journal-title":"PLOS One"},{"key":"10.1016\/j.oret.2025.05.012_bib14","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1097\/IAE.0000000000003029","article-title":"Changes in subfoveal choroidal thickness after intravitreal dexamethasone implant therapy for diabetic macular edema","volume":"41","author":"Moon","year":"2021","journal-title":"Retina"},{"key":"10.1016\/j.oret.2025.05.012_bib15","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1097\/IAE.0000000000000998","article-title":"Choroidal thickness in patients with central serous chorioretinopathy: assessment of Haller and Sattler Layers","volume":"36","author":"Chung","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.oret.2025.05.012_bib16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ajo.2013.04.008","article-title":"Enhanced depth imaging optical coherence tomography of the choroid in central retinal vein occlusion","volume":"156","author":"Tsuiki","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib17","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ophtha.2010.09.012","article-title":"Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration","volume":"118","author":"Chung","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2025.05.012_bib18","first-page":"725","article-title":"Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion","volume":"9","author":"Coban-Karatas","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib19","first-page":"572","article-title":"Subfoveal choroidal thickness and treatment outcomes of intravitreal aflibercept for branch retinal vein occlusion","volume":"11","author":"Sakanishi","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.oret.2025.05.012_bib20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/IAE.0000000000001566","article-title":"Choroidal blood flow and thickness as predictors for response to anti-vascular endothelial growth factor therapy in macular edema secondary to branch retinal vein occlusion","volume":"38","author":"Okamoto","year":"2018","journal-title":"Retina"},{"key":"10.1016\/j.oret.2025.05.012_bib21","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.ophtha.2007.09.012","article-title":"Pharmacokinetics of intravitreal ranibizumab (Lucentis)","volume":"114","author":"Bakri","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2025.05.012_bib22","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3109\/02713683.2012.727521","article-title":"Pharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET\/CT","volume":"37","author":"Christoforidis","year":"2012","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.oret.2025.05.012_bib23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ajo.2011.01.040","article-title":"Levels of VEGF but not VEGF(165b) are increased in the vitreous of patients with retinal vein occlusion","volume":"152","author":"Ehlken","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib24","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.ophtha.2011.02.022","article-title":"Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study","volume":"118","author":"Brown","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oret.2025.05.012_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamaophthalmol.2013.5515","article-title":"Branch retinal vein occlusion: Natural history of visual outcome","volume":"132","author":"Hayreh","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00417-019-04495-9","article-title":"Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy","volume":"258","author":"Suzuki","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib27","article-title":"OCT angiography features associated with macular edema recurrence after intravitreal bevacizumab treatment in branch retinal vein occlusion","volume":"9","author":"Choi","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.oret.2025.05.012_bib28","first-page":"689","article-title":"Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF","volume":"40","author":"Tilton","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2025.05.012_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12886-019-1143-9","article-title":"Comparison of subfoveal choroidal thickness in eyes with CRVO and BRVO","volume":"19","author":"Tang","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000512357","article-title":"Relationship between recurrence of macular edema due to branch retinal vein occlusion and changes in choroidal thickness","volume":"64","author":"Sakanishi","year":"2021","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.oret.2025.05.012_bib31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ajo.2014.10.034","article-title":"Distribution and determinants of choroidal thickness and volume using automated segmentation software in a population-based study","volume":"159","author":"Gupta","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajo.2009.04.029","article-title":"Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes","volume":"148","author":"Fujiwara","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oret.2025.05.012_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1167\/iovs.11-8782","article-title":"Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography","volume":"53","author":"Tan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oret.2025.05.012_bib34","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1167\/iovs.11-7364","article-title":"Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics","volume":"52","author":"Chakraborty","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ophthalmology Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653025002192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468653025002192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:55:16Z","timestamp":1762314916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468653025002192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2468653025002192"],"URL":"https:\/\/doi.org\/10.1016\/j.oret.2025.05.012","relation":{},"ISSN":["2468-6530"],"issn-type":[{"value":"2468-6530","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recurrence of Macular Edema in Branch Retinal Vein Occlusion","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Retina","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oret.2025.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of American Academy of Ophthalmology","name":"copyright","label":"Copyright"}]}}