{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:13:35Z","timestamp":1775841215103,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005317","name":"Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","award":["990419"],"award-info":[{"award-number":["990419"]}],"id":[{"id":"10.13039\/501100005317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Orthodontics"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ortho.2021.06.005","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T08:26:40Z","timestamp":1627028800000},"page":"346-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["A meta-analysis and trial sequential analysis of serum copeptin level in adult patients with Obstructive Sleep Apnoea Syndrome"],"prefix":"10.1016","volume":"19","author":[{"given":"Amin","family":"Golshah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimia","family":"Marjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Mozaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafiseh","family":"Nikkerdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Safaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedaiat","family":"Moradpoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roohollah","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ortho.2021.06.005_bib0235","first-page":"1","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"L\u00e9vy","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ortho.2021.06.005_bib0240","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S2213-2600(15)00051-X","article-title":"On the cutting edge of obstructive sleep apnoea: where next?","volume":"3","author":"Malhotra","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ortho.2021.06.005_bib0245","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1164\/ajrccm.163.3.9911064","article-title":"Prevalence of sleep-disordered breathing in women: effects of gender","volume":"163","author":"Bixler","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ortho.2021.06.005_bib0250","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ortho.2021.06.005_bib0255","doi-asserted-by":"crossref","first-page":"568823","DOI":"10.3389\/fendo.2020.568823","article-title":"Associations between morning salivary and blood cortisol concentrations in individuals with obstructive sleep apnea syndrome: a meta-analysis","volume":"11","author":"Imani","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ortho.2021.06.005_bib0260","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.ortho.2021.06.005_bib0265","first-page":"589","article-title":"Copeptin: a new predictor for severe obstructive sleep apnea","volume":"11","author":"\u00c7\u0131narka","year":"2015","journal-title":"Therapeutics and clinical risk management"},{"key":"10.1016\/j.ortho.2021.06.005_bib0270","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5152\/ejp.2015.78941","article-title":"A different clinical type of OSAS: REM-related OSAS","volume":"17","author":"K\u00f6seo\u011flu","year":"2015","journal-title":"Eurasian J Pulmonol"},{"key":"10.1016\/j.ortho.2021.06.005_bib0275","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.smrv.2014.11.004","article-title":"Biomarkers associated with obstructive sleep apnea: a scoping review","volume":"23","author":"Canto","year":"2015","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.ortho.2021.06.005_bib0280","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.106.685503","article-title":"C-terminal proVasopressin (Copeptin) as a Novel and Prognostic Marker In Acute Myocardial Infarction-The Leicester Acute Myocardial infarction Peptide (LAMP) Study","volume":"115","author":"Khan","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ortho.2021.06.005_bib0285","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/eurheartj\/ehp098","article-title":"C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study","volume":"30","author":"Voors","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ortho.2021.06.005_bib0290","doi-asserted-by":"crossref","first-page":"172","DOI":"10.11613\/BM.2013.021","article-title":"Copeptin and its potential role in diagnosis and prognosis of various diseases","volume":"23","author":"Dob\u0161a","year":"2013","journal-title":"Biochem Med"},{"key":"10.1016\/j.ortho.2021.06.005_bib0295","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1210\/jc.2007-0232","article-title":"Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects","volume":"92","author":"Szinnai","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ortho.2021.06.005_bib0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tem.2007.11.001","article-title":"Copeptin: clinical use of a new biomarker","volume":"19","author":"Morgenthaler","year":"2008","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ortho.2021.06.005_bib0305","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ijo.2012.88","article-title":"Copeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malm\u00f6 Diet and Cancer Study cardiovascular cohort","volume":"37","author":"Enh\u00f6rning","year":"2013","journal-title":"Int J Obes"},{"key":"10.1016\/j.ortho.2021.06.005_bib0310","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.2337\/dc08-s272","article-title":"Abdominal fat and sleep apnea: the chicken or the egg?","volume":"31","author":"Pillar","year":"2008","journal-title":"Diabetes care"},{"key":"10.1016\/j.ortho.2021.06.005_bib0315","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1378\/chest.09-0360","article-title":"Interactions between obesity and obstructive sleep apnea: implications for treatment","volume":"137","author":"Romero-Corral","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.ortho.2021.06.005_bib0320","doi-asserted-by":"crossref","first-page":"1939740","DOI":"10.1155\/2019\/1939740","article-title":"Evaluation of Copeptin during Pulmonary Exacerbation in Cystic Fibrosis","volume":"2019","author":"Wojsyk-Banaszak","year":"2019","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ortho.2021.06.005_bib0325","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11154-014-9304-x","article-title":"Inflammation in sleep apnea: an update","volume":"16","author":"Unnikrishnan","year":"2015","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"key":"10.1016\/j.ortho.2021.06.005_bib0330","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cyto.2013.02.021","article-title":"Profile of circulating cytokines: impact of OSA, obesity and acute cardiovascular events","volume":"62","author":"Testelmans","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.ortho.2021.06.005_bib0335","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/life10060087","article-title":"Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression","volume":"10","author":"Imani","year":"2020","journal-title":"Life"},{"key":"10.1016\/j.ortho.2021.06.005_bib0340","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3389\/fimmu.2020.01343","article-title":"Evaluation of serum and plasma interleukin-6 levels in obstructive sleep apnea syndrome (OSAS): A meta-analysis and meta-regression","volume":"11","author":"Moslem Imani","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.ortho.2021.06.005_bib0345","first-page":"1721","article-title":"The serum copeptin levels in obstructive sleep apnea patients with prehypertensive","volume":"19","author":"Akkoyun","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.ortho.2021.06.005_bib0350","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int J Surg"},{"key":"10.1016\/j.ortho.2021.06.005_bib0355","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jcms.2015.03.031","article-title":"Can we use serum copeptin levels as a biomarker in obstructive sleep apnea syndrome?","volume":"43","author":"Selcuk","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ortho.2021.06.005_bib0360","series-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses Ottawa","author":"Wells G.","year":"2011"},{"key":"10.1016\/j.ortho.2021.06.005_bib0365","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.ortho.2021.06.005_bib0370","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ortho.2021.06.005_bib0375","doi-asserted-by":"crossref","first-page":"e011890","DOI":"10.1136\/bmjopen-2016-011890","article-title":"False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review","volume":"6","author":"Imberger","year":"2016","journal-title":"BMJ open"},{"key":"10.1016\/j.ortho.2021.06.005_bib0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12874-017-0315-7","article-title":"Trial sequential analysis in systematic reviews with meta-analysis","volume":"17","author":"Wetterslev","year":"2017","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.ortho.2021.06.005_bib0385","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s11325-013-0822-7","article-title":"Low serum copeptin levels in patients with obstructive sleep apnea","volume":"17","author":"Ozben","year":"2013","journal-title":"Sleep Breath"},{"key":"10.1016\/j.ortho.2021.06.005_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-021-01704-0","article-title":"Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea\u2014a prospective intervention study","volume":"22","author":"Karakioulaki","year":"2021","journal-title":"Respiratory research"},{"key":"10.1016\/j.ortho.2021.06.005_bib0395","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/crj.13175","article-title":"The relationship between obstructive sleep apnea syndrome and obesity: a new perspective on the pathogenesis in terms of organ crosstalk","volume":"14","author":"Kuvat","year":"2020","journal-title":"Clin Respir J"},{"key":"10.1016\/j.ortho.2021.06.005_bib0400","doi-asserted-by":"crossref","first-page":"151","DOI":"10.14503\/THIJ-15-5678","article-title":"Obstructive sleep apnea in heart failure: review of prevalence, treatment with continuous positive airway pressure, and prognosis","volume":"45","author":"Khattak","year":"2018","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.ortho.2021.06.005_bib0405","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2217\/bmm.14.50","article-title":"Copeptin as a biomarker in heart failure","volume":"8","author":"Balling","year":"2014","journal-title":"Biomark Med"},{"key":"10.1016\/j.ortho.2021.06.005_bib0410","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2362.2006.01724.x","article-title":"Copeptin, a fragment of the vasopressin precursor, as a novel predictor of outcome in heart failure","volume":"36","author":"Stoiser","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ortho.2021.06.005_bib0415","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2017.10.001","article-title":"Copeptin in heart failure: Review and meta-analysis","volume":"475","author":"Zhong","year":"2017","journal-title":"Clinica chimica acta"},{"key":"10.1016\/j.ortho.2021.06.005_bib0420","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/imj.12526","article-title":"Rapid rule out of myocardial infarction with the use of copeptin as a biomarker for cardiac injury","volume":"44","author":"Jayasinghe","year":"2014","journal-title":"Intern Med J"},{"key":"10.1016\/j.ortho.2021.06.005_bib0425","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jacc.2010.01.029","article-title":"Copeptin improves early diagnosis of acute myocardial infarction","volume":"55","author":"Keller","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ortho.2021.06.005_bib0430","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1097\/HJH.0000000000001106","article-title":"Copeptin is increased in resistant hypertension","volume":"34","author":"Mendes","year":"2016","journal-title":"J Hypertens"},{"key":"10.1016\/j.ortho.2021.06.005_bib0435","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00467-013-2683-5","article-title":"Serum copeptin levels in adolescents with primary hypertension","volume":"29","author":"Tenderenda-Banasiuk","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ortho.2021.06.005_bib0440","first-page":"00019","article-title":"Obstructive sleep apnea and obesity: implications for public health","volume":"1","author":"Jehan","year":"2017","journal-title":"Sleep Med Disord"},{"key":"10.1016\/j.ortho.2021.06.005_bib0445","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00431-020-03777-3","article-title":"Distribution of plasma copeptin levels and influence of obesity in children and adolescents","volume":"180","author":"Tuli","year":"2021","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ortho.2021.06.005_bib0450","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-20-0077","article-title":"In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone","volume":"183","author":"van der Valk","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ortho.2021.06.005_bib0455","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000196049","article-title":"Changes of circulating atrial natriuretic peptide and antidiuretic hormone in obstructive sleep apnea syndrome","volume":"59","author":"Ichioka","year":"1992","journal-title":"Respiration"},{"key":"10.1016\/j.ortho.2021.06.005_bib0460","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/cs0800443","article-title":"Effects of treatment with nasal continuous positive airway pressure on atrial natriuretic peptide and arginine vasopressin release during sleep in patients with obstructive sleep apnoea","volume":"80","author":"Krieger","year":"1991","journal-title":"Clin Sci (Lond)"}],"container-title":["International Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S176172272100084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S176172272100084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:09:26Z","timestamp":1761707366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S176172272100084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S176172272100084X"],"URL":"https:\/\/doi.org\/10.1016\/j.ortho.2021.06.005","relation":{},"ISSN":["1761-7227"],"issn-type":[{"value":"1761-7227","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A meta-analysis and trial sequential analysis of serum copeptin level in adult patients with Obstructive Sleep Apnoea Syndrome","name":"articletitle","label":"Article Title"},{"value":"International Orthodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ortho.2021.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 CEO. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}