{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:19:22Z","timestamp":1792019962063,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008115","name":"School of Dentistry, University of Michigan","doi-asserted-by":"publisher","award":["IR.SBMU.DRC.REC.1400.156"],"award-info":[{"award-number":["IR.SBMU.DRC.REC.1400.156"]}],"id":[{"id":"10.13039\/100008115","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Orthodontics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ortho.2023.100725","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T14:48:41Z","timestamp":1674053321000},"page":"100725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of shear bond strength and enamel remineralizing effect of experimental orthodontic composite containing nano-hydroxyapatite: An in vitro study"],"prefix":"10.1016","volume":"21","author":[{"given":"Sina","family":"Rahmanpanah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoud","family":"Seifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Gharavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Sadighnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Amdjadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ortho.2023.100725_bib0275","doi-asserted-by":"crossref","first-page":"e010","DOI":"10.1590\/1807-3107bor-2019.vol33.0010","article-title":"Evaluation of an antibacterial orthodontic adhesive incorporated with niobium-based bioglass: an in-situ study","volume":"33","author":"Degrazia","year":"2019","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0280","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1590\/2177-6709.24.6.048-055.oar","article-title":"Efficacy of fluoride associated with nano-hydroxyapatite in reducing enamel demineralization adjacent to orthodontic brackets: in situ study","volume":"24","author":"Demito","year":"2019","journal-title":"Dental Press J Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0285","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3109\/00016357.2012.741699","article-title":"Investigating the effect of incorporating nanosilver\/nanohydroxyapatite particles on the shear bond strength of orthodontic adhesives","volume":"71","author":"Akhavan","year":"2013","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ortho.2023.100725_bib0290","doi-asserted-by":"crossref","first-page":"705 e1-9","DOI":"10.1016\/j.ajodo.2006.09.043","article-title":"Prevention of demineralization around orthodontic brackets in vitro","volume":"131","author":"Sudjalim","year":"2007","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ortho.2023.100725_bib0295","doi-asserted-by":"crossref","first-page":"571","DOI":"10.12693\/APhysPolA.131.571","article-title":"An in vitro comparison of the enamel remineralisation potential of bioactive glass, hydroxyapatite and CPP-ACP","volume":"131","author":"G\u00fc\u00e7l\u00fc","year":"2017","journal-title":"Acta Phys Pol A"},{"key":"10.1016\/j.ortho.2023.100725_bib0300","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jdent.2018.05.017","article-title":"Effect of bioactive glass-containing resin composite on dentin remineralization","volume":"75","author":"Jang","year":"2018","journal-title":"J Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0305","doi-asserted-by":"crossref","first-page":"e920510","DOI":"10.12659\/MSMBR.920510","article-title":"Antimicrobial effect of orthodontic materials on cariogenic bacteria streptococcus mutans and Lactobacillus acidophilus","volume":"26","author":"Krasniqi","year":"2020","journal-title":"Med Sci Monit Basic Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0310","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40510-016-0153-x","article-title":"Evaluation of the antibacterial activity of a conventional orthodontic composite containing silver\/hydroxyapatite nanoparticles","volume":"17","author":"Sodagar","year":"2016","journal-title":"Prog Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0315","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3390\/ma12040652","article-title":"Antibacterial and remineralizing fillers in experimental orthodontic adhesives","volume":"12","author":"Ferreira","year":"2019","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.ortho.2023.100725_bib0320","first-page":"4183","article-title":"Mechanisms of bioactive glass on caries management: a review materials (Basel)","volume":"12","author":"Dai","year":"2019"},{"key":"10.1016\/j.ortho.2023.100725_bib0325","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3897\/folmed.63.e56657","article-title":"Shear bond strength of self-adhesive composite containing TiO2and SiO2\u00a0Nanoparticles with an additional etching step for orthodontic brackets bonding to enamel","volume":"63","author":"Nikpour","year":"2021","journal-title":"Folia Med"},{"key":"10.1016\/j.ortho.2023.100725_bib0330","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ortho.2020.01.011","article-title":"An in vitro evaluation of the effects of nanoparticles on shear bond strength and antimicrobial properties of orthodontic adhesives: A systematic review and meta-analysis study","volume":"18","author":"Pourhajibagher","year":"2020","journal-title":"Int Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0335","first-page":"ZC142","article-title":"Microhardness and penetration of artificial white spot lesions treated with resin or colloidal silica infiltration","volume":"11","author":"Mandava","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0340","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/00016357.2013.859728","article-title":"Nanoparticles in orthodontics, a review of antimicrobial and anti-caries applications","volume":"72","author":"Borzabadi-Farahani","year":"2014","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ortho.2023.100725_bib0345","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.sdentj.2021.01.001","article-title":"Evaluation the properties of orthodontic adhesive incorporated with nano-hydroxyapatite particles","volume":"33","author":"Hasan","year":"2021","journal-title":"Saudi Dent J"},{"key":"10.1016\/j.ortho.2023.100725_bib0350","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1159\/000331207","article-title":"Remineralization potential of nano-hydroxyapatite on initial enamel lesions: an in vitro study","volume":"45","author":"Huang","year":"2011","journal-title":"Caries Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0355","first-page":"012050","article-title":"Preparation of dental composite using hydroxyapatite from natural sources and Silica","volume":"1097","author":"Razali","year":"2018","journal-title":"JPCS"},{"key":"10.1016\/j.ortho.2023.100725_bib0360","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1023\/A:1011291723503","article-title":"Hydroxyapatite as a filler for dental composite materials: mechanical properties and in vitro bioactivity of composites","volume":"12","author":"Santos","year":"2001","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.ortho.2023.100725_bib0365","first-page":"2172365","article-title":"Hydroxyapatite whiskers based resin composite versus commercial dental composites: mechanical and biocompatibility characterization","author":"Calabrese","year":"2016","journal-title":"Adv Mater Sci Eng"},{"key":"10.1016\/j.ortho.2023.100725_bib0370","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1166\/jnn.2010.2422","article-title":"Physical properties of resin-reinforced glass ionomer cement modified with micro and nano-hydroxyapatite","volume":"10","author":"Lee","year":"2010","journal-title":"J Nanosci Nanotechnol"},{"key":"10.1016\/j.ortho.2023.100725_bib0375","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3390\/cryst11060674","article-title":"Dental applications of systems based on hydroxyapatite nanoparticles\u2013an evidence-based update","volume":"11","author":"Balhuc","year":"2021","journal-title":"Crystals"},{"key":"10.1016\/j.ortho.2023.100725_bib0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12903-019-0785-6","article-title":"Effect of hydroxyapatite nanoparticles on enamel remineralization and estimation of fissure sealant bond strength to remineralized tooth surfaces: an in vitro study","volume":"19","author":"Memarpour","year":"2019","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ortho.2023.100725_bib0385","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.3390\/polym13162740","article-title":"SEM\/EDS Evaluation of the Mineral Deposition on a Polymeric Composite Resin of a Toothpaste Containing Biomimetic Zn-Carbonate Hydroxyapatite (microRepair(\u00ae)) in Oral Environment: A Randomized Clinical Trial","volume":"13","author":"Butera","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ortho.2023.100725_bib0390","first-page":"172","article-title":"Assessment of tooth preparation via Er:YAG laser and bur on microleakage of dentin adhesives","volume":"11","author":"Bahrololoomi","year":"2014","journal-title":"J Dent (Tehran)"},{"key":"10.1016\/j.ortho.2023.100725_bib0395","doi-asserted-by":"crossref","DOI":"10.2174\/18742106-v16-e2205310","article-title":"Effect of 0.2% Chitosan associated with different final irrigant protocols on the fiber post bond strength to root canal dentin of bovine teeth: an in-vitro study","volume":"16","author":"Dorileo","year":"2022","journal-title":"Open Dent J"},{"key":"10.1016\/j.ortho.2023.100725_bib0400","unstructured":"ISO\/TS 11405:2003, Dental materials \u2014 Testing of adhesion to tooth structure."},{"key":"10.1016\/j.ortho.2023.100725_bib0405","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jdent.2013.01.001","article-title":"The addition of nanostructured hydroxyapatite to an experimental adhesive resin","volume":"41","author":"Leitune","year":"2013","journal-title":"J Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0410","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.4103\/ccd.ccd_2_18","article-title":"Bond strength of an orthodontic adhesive containing an antibiofilm agent (Octafluoropentyl Methacrylate)","volume":"9","author":"Dastjerdi","year":"2018","journal-title":"Contemp Clin Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0415","doi-asserted-by":"crossref","DOI":"10.4103\/jos.jos_139_21","article-title":"Impact of fluoride-releasing orthodontic adhesives on the shear bond strength of orthodontic brackets to eroded enamel following different surface treatment protocols","volume":"11","author":"Althagafi","year":"2022","journal-title":"J Orthod Sci"},{"key":"10.1016\/j.ortho.2023.100725_bib0420","doi-asserted-by":"crossref","first-page":"100613","DOI":"10.1016\/j.ortho.2022.100613","article-title":"Evaluation and comparison of antibacterial and physicochemical properties of synthesized zinc oxide-nano particle-containing adhesive with commercial adhesive: An experimental study","volume":"20","author":"Behnaz","year":"2022","journal-title":"Int Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0425","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ortho.2021.09.001","article-title":"Comparison of the failure rate, bonding time and ARI score of two orthodontic bonding systems: Self-Etch Primer and Conventional Etching Primer: A systematic review and meta-analysis","volume":"19","author":"Namdari","year":"2021","journal-title":"Int Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0430","doi-asserted-by":"crossref","first-page":"104306","DOI":"10.1016\/j.jdent.2022.104306","article-title":"An assessment of mineral concentration of dental enamel neighbouring hypothetical orthodontic brackets using X-ray microtomography","volume":"126","author":"Al-Khafaji","year":"2022","journal-title":"J Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0435","article-title":"Comparative study of amorphous calcium phosphate-containing orthodontic composite and conventional orthodontic adhesive on enamel demineralization around orthodontic brackets \u2013 An in vivo Study","volume":"3","author":"Agarwal","year":"2014","journal-title":"Orthod J Nepal"},{"key":"10.1016\/j.ortho.2023.100725_bib0440","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0889-5406(03)00571-7","article-title":"In vivo effect of a resin-modified glass ionomer cement on enamel demineralization around orthodontic brackets","volume":"125","author":"Pascotto","year":"2004","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ortho.2023.100725_bib0445","doi-asserted-by":"crossref","first-page":"S1106","DOI":"10.4103\/jpbs.jpbs_259_21","article-title":"Evaluation of change in surface enamel microhardness in patients undergoing fixed orthodontic appliance therapy - a randomized control trial","volume":"13","author":"Rajendran","year":"2021","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.ortho.2023.100725_bib0450","first-page":"ZC97","article-title":"Impact of nano hydroxyapatite nano silver fluoride and sodium fluoride varnish on primary teeth enamel remineralization: an in vitro study","volume":"11","author":"Nozari","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0455","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2319\/020411-78.1","article-title":"Effects of bonding materials on the mechanical properties of enamel around orthodontic brackets","volume":"82","author":"Kohda","year":"2011","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0460","doi-asserted-by":"crossref","first-page":"e10752","DOI":"10.1016\/j.heliyon.2022.e10752","article-title":"Effect of sodium fluoride plus tricalcium phosphate with and without CO2 laser on remineralization of white spot lesions","volume":"8","author":"Eissa","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.ortho.2023.100725_bib0465","first-page":"77","article-title":"A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity-proof of principle","volume":"21","author":"Litkowski","year":"2010","journal-title":"J Clin Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0470","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000259635","article-title":"Experimental caries in man","volume":"4","author":"Von der Fehr","year":"1970","journal-title":"Caries Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0475","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1590\/1807-3107bor-2019.vol33.0101","article-title":"Mineral deposition promoted by resin-based sealants with different calcium phosphate additions","volume":"33","author":"Bohns","year":"2019","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0480","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/dj7030091","article-title":"Remineralization of demineralized enamel and dentine using 3 dentifrices-An InVitro Study","volume":"7","author":"Talwar","year":"2019","journal-title":"Dent J (Basel)"},{"key":"10.1016\/j.ortho.2023.100725_bib0485","first-page":"208","article-title":"Effect of Nano-Hydroxyapatite Incorporation into Resin Modified Glass Ionomer Cement on Ceramic Bracket Debonding","volume":"26","author":"Nuri Sari","year":"2014","journal-title":"JIDA"},{"key":"10.1016\/j.ortho.2023.100725_bib0490","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0109-5641(03)00110-6","article-title":"Ultimate tensile strength of tooth structures","volume":"20","author":"Giannini","year":"2004","journal-title":"Dent Mater"},{"key":"10.1016\/j.ortho.2023.100725_bib0495","first-page":"e919","article-title":"Effect of saliva contamination on cementation of orthodontic brackets using different adhesive systems","volume":"9","author":"Robaski","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0500","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ajodo.2004.10.017","article-title":"The effect of bleaching on shear bond strength of brackets bonded with a resin-modified glass ionomer","volume":"130","author":"Cacciafesta","year":"2006","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ortho.2023.100725_bib0505","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2319\/020807-60","article-title":"Bond strength of an amorphous calcium phosphate-containing orthodontic adhesive","volume":"78","author":"Foster","year":"2008","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ortho.2023.100725_bib0510","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/154405910708600813","article-title":"Antimicrobial effect of nanometric bioactive glass 45S5","volume":"86","author":"Waltimo","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0515","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3390\/jcm9030772","article-title":"Bioactivity and physico-chemical properties of dental composites functionalized with nano- vs micro-sized bioactive glass","volume":"9","author":"Odermatt","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.ortho.2023.100725_bib0520","doi-asserted-by":"crossref","first-page":"635","DOI":"10.5005\/jp-journals-10024-1903","article-title":"Nano-hydroxyapatite could compensate the adverse effect of soft carbonated drinks on enamel","volume":"17","author":"Rezvani","year":"2016","journal-title":"J Contemp Dent Pract"},{"key":"10.1016\/j.ortho.2023.100725_bib0525","first-page":"ZC64","article-title":"In Vitro evaluation of enamel microhardness after application of two types of fluoride varnish","volume":"11","author":"Molaasadolah","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.ortho.2023.100725_bib0530","doi-asserted-by":"crossref","first-page":"6747498","DOI":"10.1155\/2020\/6747498","article-title":"Biomimetic effect of nano-hydroxyapatite in demineralized enamel before orthodontic bonding of brackets and attachments: visual, adhesion strength, and hardness in in vitro tests","author":"Scribante","year":"2020","journal-title":"BioMed Research International"},{"key":"10.1016\/j.ortho.2023.100725_bib0535","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4103\/jispcd.JISPCD_64_21","article-title":"The efficacy of non-fluoridated toothpastes on artificial enamel caries in primary teeth: an in vitro study","volume":"11","author":"Kasemkhun","year":"2021","journal-title":"J Int Soc Prev Community Dent"},{"key":"10.1016\/j.ortho.2023.100725_bib0540","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1038\/s41598-018-27304-5","article-title":"In vitro and in vivo evaluation of electrophoresis-aided casein phosphopeptide-amorphous calcium phosphate remineralisation system on pH-cycling and acid-etching demineralised enamel","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci Rep"}],"container-title":["International Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1761722723000049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1761722723000049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:09:45Z","timestamp":1761707385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1761722723000049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1761722723000049"],"URL":"https:\/\/doi.org\/10.1016\/j.ortho.2023.100725","relation":{},"ISSN":["1761-7227"],"issn-type":[{"value":"1761-7227","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of shear bond strength and enamel remineralizing effect of experimental orthodontic composite containing nano-hydroxyapatite: An in vitro study","name":"articletitle","label":"Article Title"},{"value":"International Orthodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ortho.2023.100725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 CEO. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100725"}}